ANEUPLOIDY IN HEALTH AND DISEASE docx
ANEUPLOIDY IN HEALTH AND DISEASE docx
... missegregation levels both in vitro
and in vivo and thus to aneuploidy.
Besides mutations in spindle assembly checkpoint and in mitotic spindle genes, aneuploidy
is also increased in cells that carry ... are
34
Aneuploidy in Health and Disease
Aneuploidy in Health and Disease
12
specific effect except for AICAR, chloroquine and 17-AAG [50]. AICAR in...
Tài liệu Aneuploidy in Health and Disease Edited by Zuzana Storchova doc
... Cancer Genomics by Jointly
Analysing Aneuploidy and Gene Expression 23
Lingling Zheng and Joseph Lucas
Chapter 3 Sister Chromatid Cohesion and Aneuploidy 41
Erwan Watrin and Claude Prigent ... Croatia
A free online edition of this book is available at www.intechopen.com
Additional hard copies can be obtained from orders@intechopen.com
Aneuploidy in Health and...
Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx
... mutation in the BTK PH domain; arginine 28 is in
dark blue, encircled in red. Bottom left: SH2 domain. Right: kinase
domain. The mutated residues are indicated in yellow, a-helices are
in cyan, ... T-cell kinase (ITK) could in uence the infectivity of HIV
and also have anti -in ammatory activity. Since 2006, several patients carry-
ing a fusion protein, originating from a translo...
Modern Nutrition in Health and Disease pot
... myofibrillar protein from tissues containing myosin and actin (muscle,
smooth muscle such as gut, skin). In man, 3-methylhistidine is quantitatively excreted into urine; in rat, 3-methylhistidine is also ... of Free Amino Acids in the Body
It is important to bear in mind the differences in the relative amounts of N contained in extracellular and intracellular amino acid pools...
Báo cáo khoa học: Regulation of matrix metalloproteinase activity in health and disease pdf
... integrin-binding ligand
N-linked glycoprotein (SIBLING)
Individual members of the SIBLING family are known
to bind strongly to both pro- and active forms of
specific MMPs. Bone sialoprotein binds ... proMMP-binding partners
involved in activation.
Allosteric activation
Gelatinase interactions with collagen and gelatin
Binding of macromolecules or specific thiol-binding
reagents to an MMP...
The Neuronal Environment: Brain Homeostasis in Health and Disease pot
... and mRNA binding to cytosolic and poly-
some proteins in brain and peripheral tissues. Brain Res. Mol. Brain Res. 58, 170–177.
39. Lauger, P. (1991) Na,K-ATPase, in Electrogenic Ion Pumps, Sinauer, ... HOMEOSTASIS AND NEUROLOGICAL DISEASE
Substantial progress has been made in the understanding of the pathophysiology and
mechanisms involved in the attenuation of brain homeo...
Báo cáo khoa học: Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans ppt
... modulated by lumican-evoked signaling,
including vinculin and focal adhesion kinase [82].
Lumican alters the relationship between actin filaments
and b1 integrin, which in turn would affect focal adhe-
sion ... with the EGF-binding domain [32]. The
structural constraints of the EGFR binding region
support a stochiometry of 1 : 1 for the decorin pro-
tein core and EGFR, suggesting that...
Báo cáo khoa học: Proteoglycans in health and disease: the multiple roles of syndecan shedding ppt
... HEXXHXXGXXH) and a conserved methionine
(Met-turn) supporting the catalytic zinc. Interaction
between cysteine–zinc maintains proMMPs in an inac-
tive state by preventing a water molecule from binding
to ... (GAIP)-interacting C-terminus ⁄
synectin and calc ium ⁄ calmodulin-associated serine kinase,
since the C2 region contains a class II PSD-95 ⁄
Discs-large ⁄ Zonula occludens protein-...
Báo cáo khoa học: Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis pptx
... Accumulating evidences indicate that
HSPGs act to inhibit cellular invasion by promoting
tight cell–cell and cell–ECM interactions, and by main-
taining the structural integrity and self-assembly ... in lung
carcinoma and chronic myeloid leukemia compared
with control tissue and cells. In this splice variant,
144 bp of intron 5 are joined with exon 4, resulting in
a 169-amino-...
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