báo cáo hóa học: " Neuroinflammation in Alzheimer’s disease wanes with age" pdf
báo cáo hóa học: " Neuroinflammation in Alzheimer’s disease wanes with age" pdf
... al.: Neuroinflammation in Alzheimer’s
disease wanes with age. Journal of Neuroinflammation 2011 8:171.
Submit your next manuscript to BioMed Central
and take full advantage of:
• Convenient online ... prominent feature in Alzheimer’s disease (AD). It has been proposed that aging has
an effect on the function of inflammation in the brain, thereby contributing to the deve...
Báo cáo khoa học: LRRK2 in Parkinson’s disease: function in cells and neurodegeneration doc
... protein.
Similar to b-RAF, LRRK2 encodes a kinase domain
with serine ⁄ threonine activity [7], but in concert with a
number of conserved domains, including a GTPase
domain. Multidomain proteins ... recognizable
substructures within the kinase domains, with the
expectation that similar kinases may be involved in
similar roles in cells. LRRK1 and LRRK2 are awk-
wardly nestled within...
Báo cáo khoa học: LRRK2 in Parkinson’s disease: in vivo models and approaches for understanding pathogenic roles pdf
... resulted in a
reduction in brain dopamine levels compared to that
of nontransgenic flies. Conversely, dopamine content
was elevated in mutant flies with a dLRRK deletion.
This increase in dopamine content ... proteins (ROC) domain followed by a
C-terminal of ROC (COR) domain of unknown
Keywords
animal models; BAC transgenics; dopamine;
GTPase; kinase; leucine-rich repeat
kinase 2 (LRR...
Báo cáo khoa học: LRRK2 in Parkinson’s disease: genetic and clinical studies from patients ppt
... WD40
domain. Because WD40 domain is involved in mediat-
ing protein–protein interactions, the LRRK2 G2385R
variant may impact on interactions with substrates
and ⁄ or regulatory proteins. Preliminary ... multidomain protein comprising (from
N-terminal to C-terminal), armadillo (ARM), ankryn
(ANK), LRR, Ras of complex proteins (ROC), C-ter-
minal of ROC (COR), mitogen-activated protein
kin...
báo cáo hóa học: " Anandamide inhibits Theiler’s virus induced VCAM-1 in brain endothelial cells and reduces leukocyte transmigration in a model of blood brain barrier by activation of CB1 receptors" pdf
... of staining intensity (Figure 3D).
The increased anandamide tone limits microglial
activation in mice infected with Theiler’s virus
The intracranial injection of Theiler’s virus induced an
increase ... established disease, understanding the role of
endocannabinoids during the induction phase would be an
important point as exacerbated leukocyte trafficking into
the CNS represents a key st...
báo cáo hóa học: " Incidence of Raynaud''''s phenomenon in relation to hand-arm vibration exposure among male workers at an engineering plant a cohort study" doc
... time
exposure (hobbies, snowmobiling, motorcycling etc) was
included in this measure based on interviews. Example, a
welder using a grinder 3 hours per day and a chisel ham-
mer 30 minutes per day for 7 ... prospective cohort included all workers
being without RP at baseline. Time to event was computed
as the number of years from baseline to the first follow up
with RP (5, 10 or 15 years)...
báo cáo hóa học:" AIDS-associated Kaposi’s sarcoma is linked to advanced disease and high mortality in a primary care HIV programme in South Africa" pdf
... an important, life-threatening opportunistic infection among
people living with HIV/AIDS in resource-limited settings. In western countries, the introduction of combination
antiretroviral therapy ... nevirapine- or efavirenz-based triple
therapy according to provincial treatment protocols.
At their initial visit, patients were examined for evi-
dence of opportunistic infections, includi...
báo cáo hóa học:" The Global Fund’s resource allocation decisions for HIV programmes: addressing those in need" pptx
... highest absolute gain
in investments over time, especially after the high rates of
approved funding in Round 8, increasing from US$0.2
billion in 2002 to $1.2 billion in 2008 and $1.1 in 2010),
while ... funding, targeted these three
groups in countries with concentrated epidemics with
the rest of the prevention funds invested in interven-
tions for the general po pulation....
báo cáo hóa học:" Generation in vivo of peptide-specific cytotoxic T cells and presence of regulatory T cells during vaccination with hTERT (class I and II) peptide-pulsed DCs" pot
... is a recombinant protein
comprising IL-2 fused with the alpha chain of diphtheria
toxin, (DAB389+IL-2), capable of transiently eliminating
T regs. Phase II/III clinical trials, involving stage ... when injected into
patients with a variety of cancers [41,42]. In our study,
autologous DC vaccines were prepared with and without
INF-α, and each pulsed with a different hTERT peptide,
an...
báo cáo hóa học:" Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis" pot
... controls.
Plasma vitamin D binding protein in critically ill subjects with sepsis, critically ill subjects without sepsis and healthy sub-jectsFigure 2
Plasma vitamin D binding protein in critically ... vitamin D status including plasma
levels of 25(OH)D and vitamin D binding protein (DBP)
and their relationship to systemic LL-37 levels in a group
of critically ill patients includin...
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