Báo cáo sinh học: "Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells" ppt

... H Open Access Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells Duo-Rong ... VX-680 inhibits activation of Aur-A and induces monopolar spindle in NB4-R2 cells. (A) VX-680 inhibited phosphorylation of Aur- A at Thr288 in NB4-...

Ngày tải lên: 18/06/2014, 19:20

... et al.: Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-trans retinoid acid-resistant acute promyelocytic leukemia cells. Journal of Translational ... H Open Access Inhibition of mitotic kinase Aurora suppresses Akt-1 activation and induces apoptotic cell death in all-tra...

Ngày tải lên: 20/06/2014, 03:20

... (10 5 cells per well in 200 µl of culture medium). TF228.1.16 cells and 293/CD4 + cells were incubated in the presence or absence of the drug (the final concentration in µg/ml is indicated in ... glycoprotein gp120 of HIV-1 and HIV-2 and syncytium inhibition with lectins. AIDS 1989, 3:635-41. 32. Malvoisin E, Wild F: The role of N-glycosylation in cell fusion in...

Ngày tải lên: 18/06/2014, 22:20

... of SU11274 on cell motility. Figure 2 Analysis of the expression and localization of phosphorylated c-MET in RMS tissue samples. Represent images of HE staining and IHC staining of myogenin and ... tyrosine kinase (RTK) that is over-expressed in a variety of cancers and involved in cell growth, invasion, metastasis and angiogenesis. In this study, we invest...

Ngày tải lên: 18/06/2014, 19:20

... locations (amino acids 450, 479 and 480) with phenylalanine, arginine and leucine in NiV replaced by tyrosine, lysine and isoleucine in HeV [6,46]. These differences in the sequence of either peptide did ... HeV and NiV make use of a cell- sur- face expressed protein and their G glycoprotein binds to ephrin-B2 on host cells [13]. The fusion protein (F) facili- tates the f...

Ngày tải lên: 19/06/2014, 08:20

... protein peroxides investigated in the current study, with GAPDH being more sensitive than GR and LDH, and inactivation of G APDH being metal- ion independent, whereas inhibition of GR and LDH by H 2 O 2 occurs ... Peroxide-containing samples in presence of added Fe 2+ –EDTA; (h) Peroxide-containing samples in absence of added Fe 2+ –EDTA; (n) nonp hotolysed/non H 2 O 2 con...

Ngày tải lên: 21/02/2014, 03:20

... anchored in the brush border epithelial cells of the small intestine. MGA contains five distinct protein domains: a small cytosolic domain (26 amino acids) a transmembrane domain (20 amino acids), ... In order to examine the mechanism of action of this class of inhibitors, 3, 5, the stereoisomers of salacinol 6, 7 [25], and the six-membered ring analogues of salacinol (8, 9)...

Ngày tải lên: 07/03/2014, 12:20

... the examination of the fundus of the eye revealed posterior uveitis and inflammatory changes of retinal ves- sels (vasculitis). On the other hand VZV intraocular infec- tion presented in 2 patients ... facilitate the routine diagnosis of herpesviruses infections, within a single assay, single clinical sample, thereby allowing earlier application of specific antiviral treatment...

Ngày tải lên: 18/06/2014, 18:20

... essential amino acids and 50 µg/ml gentamicin reagent solution (Invitrogen, Carlsbad, CA,). 3201 is an FeLV-negative thymic lymphoma cell line of feline origin [32] and was maintained in 50% Leibovitz L-15 ... inserted into the multiple cloning site of pcDNA3.1 (a gift of Dr. Linda Wolff, National Cancer Institute). DNA-protein binding reactions included 5 µg of nuclear extrac...

Ngày tải lên: 18/06/2014, 22:20

... CA). Identification of inhibitor properties The characteristics of CHEC-9 inhibition were determined using both classical characterization of inhibitor types, i.e., the direction of changes in Km and Vmax, and ... the addition of the substrate solution to the sPLA2 containing samples. Kinetic parameters including the properties of CHEC-9 were determined by measuring the init...

Ngày tải lên: 19/06/2014, 22:20