gene therapy for liver disease

... to liver diseases resulting in liver failure. To date, therapy for alcoholic liver disease is the cessation of alcohol con- sumption and in the case of end-stage liver disease (liver failure) liver ... the therapeutic gene. Alternatively, dif- ferent viral vectors as well as liposomes can be used for ex vivo gene transfer. 154 GENE THERAPY FOR LIVER DISEASE...

Ngày tải lên: 10/04/2014, 22:11

... for 140 days, indicating that DGJ is well toler- ated in mice. ASSC therapy for Fabry disease in humans The clinical proof-of-concept for ASSC therapy has been investigated in cardiac Fabry disease ... or end-stage renal failure [8]. The prevalence of Fabry disease is estimated at 1 : 40 000 for the classic form. The incidence of the variant form of Fabry disease was found...

Ngày tải lên: 30/03/2014, 03:20

... low-level gene transfer, no clear in vivo selection with chemotherapy 144 GENE THERAPY FOR HEMATOLOGICAL DISORDERS restoration of cellular and humoral immunity were documented after gene therapy. Data ... the FAC or FAA gene. A possible in vivo survival advantage for gene- corrected prim- itive cells and their progeny has made FA an attractive candidate disease for stem ce...

Ngày tải lên: 10/04/2014, 22:10

... of restenosis. • Gene therapy for therapeutic neovascularization targets angiogenic growth factors. 198 GENE THERAPY IN CARDIOVASCULAR DISEASE • Gene therapy offers a new avenue for the modification ... the gene, preventing the translation into protein. Another form of gene blockade is the use 184 GENE THERAPY IN CARDIOVASCULAR DISEASE FIGURE 8.1 Gene therapy st...

Ngày tải lên: 10/04/2014, 22:11

... retroviral-mediated gene transfer is currently the optimal gene transfer system available for use in HIV-1 gene therapy. The PRACTICAL ASPECTS OF GENE THERAPY FOR HIV 281 CHAPTER 11 Gene Therapy for HIV ... clinical protocol for AIDS gene therapy uses retroviral-mediated gene transfer to deliver antisense TAR and RevTD genes to syngeneic lymphocytes in identical...

Ngày tải lên: 10/04/2014, 22:11

... of other liver diseases based on standard clinical, laboratory, imaging and/or liver biopsy features. Laboratory tests to rule out other liver diseases included a viral hepatitis panel (for hepatitis ... liver disease with the consequent need for liver transplantation. NAFLD in children seen in a tertiary care centre may be associated with a significantly shorter survival as co...

Ngày tải lên: 22/03/2014, 10:20

... Suppressor Gene 155 Inhibition of Growth Factor Receptors 157 Molecular Chemotherapy 157 Antiangiogenic Gene Therapy 157 Virotherapy 158 Gene Therapy for Other Gynecological Cancers 159 Gene Therapy for ... developmental gene transfer applications for gynecological diseases. Key Words: gene transfer, gene therapy, ovarian cancer, cervical cancer, gynecological dise...

Ngày tải lên: 22/03/2014, 11:20

... environmental factors on liver diseases. Environmental exposure related to toxic waste sites was associated with an increased prevalence of au- toimmune liver disease (83, 84). Therefore, increasing ... pollution on liver disease in the general population. A large population-based study was conducted on 4582 adult participants without viral hep- atitis, hemochromatosis, or alcoh...

Ngày tải lên: 29/03/2014, 18:20

... al. (1999) A novel gene delivery system for genetic manipulation of sinusoidal )endothelial cells by triplex DNA technology: evaluation of targetability and abil- ity to stabilize triplex formation. ... allows design and synthesis of functional gene carrier molecules such as carbohydrate-modified peptide for targeted gene delivery. Furthermore, peptide-based gene carrier enables c...

Ngày tải lên: 11/04/2014, 09:59