Báo cáo Y học: A new conceptual framework for enzyme catalysis Hydrogen tunneling coupled to enzyme dynamics in flavoprotein and quinoprotein enzymes docx

... MINIREVIEW A new conceptual framework for enzyme catalysis Hydrogen tunneling coupled to enzyme dynamics in flavoprotein and quinoprotein enzymes Michael J. Sutcliffe 1,2 and Nigel S. Scrutton 1 Departments ... these enzymes. QUINOPROTEIN AND FLAVOPROTEIN AMINE DEHYDROGENASES The quinoprotein and flavoprotein amine dehydrogenases are ideally...

Ngày tải lên: 31/03/2014, 23:20

... 5¢-CGGGCTCGGC ACTGAGCAGCGCGTTCGCCTCGCCGCCGGTC-3¢ (L5 8A as), 85¢-CAGTCTGGGACCAAGAACGCGCGC ATCCAGTGTGAGGGG-3¢ (L9 3A s), 5¢-CCCCTCACA CTGGATGCGCGCGTTCTTGGTCCCAGACTG-3¢ (L9 3A as), 5¢-GTCTGGGACCAAGAACCTGGAAAT CCAGTGTGAGGGGGGCAGC-3¢ (R94E ... that this peptide binds in a way very similar to pY429pY431 with the residues Y) 2, Y+ 3, Y+ 4 and Y+ 5 building up hydrophobic contacts to...

Ngày tải lên: 24/03/2014, 00:21

... ITIM-signaling motifs (Y5 97 and Y6 67) and are likely involved in intracellular signaling. The ability of tyrosine kinases to phosphorylate the cytoplasmic tyrosines was evaluated by kinase assay using ... macrophages and lymphocytes increase in number at sites of in ammation and each are capable of modifying the overall in ammatory response [23]. Eosinophils, are of particu...

Ngày tải lên: 24/03/2014, 04:21

... to their role in global carbon cycling, diatoms have recently attracted interdisciplinary interest because of their extraordinary ability to produce intricately shaped, nanostructured silica as their ... molybdopterin domain (aa 54–295), dimerization domain (aa 321–447), heme domain (aa 519–592), FAD domain (aa 623–728) and NADH domain (residues 744–858) [27]. A unique 17-amino-acid...

Ngày tải lên: 07/03/2014, 21:20

... (Goel and Byrne, 2000), statistical machine translation (Kumar and Byrne, 2004) and statis- tical information retrieval (Zhai and Lafferty, 2006). Following the same spirit, we formulate the ... difficult to replicate or ex- tend from constrained domains to more general domains. In addition to being extractive or ab- stractive, a summary may also be generated by conside...

Ngày tải lên: 16/03/2014, 23:20

... mecha- nism and derivation in favor of defining languages as classes of more or less ordinary mathematical struc- tures axiomatized by sets of more or less ordinary logical formulae. A grammatical ... property. Chain(X) (3!x)[X(x) A Target(x)] A X contains exactly one Target (3!x)[X(x) A Base(x)] A and one Base (Vx)[X(x) A -~Warget(x) * (3 !y) [Z (y) A Link (y...

Ngày tải lên: 17/03/2014, 09:20

... classification task for all arguments, evaluated using PropBank and AQUAINT as the training and testing corpora, respectively. Since the rela- tion edges have a form Target k -> Arg l , the rela- tion ... extracted from the training data, TrainT + ⊂ TrainT be the subset of correct candidate templates, and TotalT + be the total set of correct templates in the training da...

Ngày tải lên: 23/03/2014, 18:20

... represen- tation (Tatu and Moldovan, 2007; MacCartney and Manning, 2007), semantic analysis (Burchardt et al., 2007) and syntactic parsing (Bar-Haim et al., 2008; Wang et al., 2009). Inference at these ... 2003. A categorial vari- ation database for english. In Proceedings of the North American Association for Computational Linguistics. Houping Jia, Xiaojiang Huang, Tengfei Ma,...

Ngày tải lên: 30/03/2014, 21:20

... extract various types of lexical and semantic relations, including is -a, part-of, sibling, synonym, causal, and many others. Pattern-based approaches started from and still pay a great deal ... research on automatic taxonomy induction. As we men- tioned earlier, two main approaches are pattern- based and clustering-based. Pattern-based approaches are the main trend for autom...

Ngày tải lên: 30/03/2014, 23:20

... site has a reduced capacity to ADP ribosylate cytoplasmic proteins, e.g. Ras, and shows a reduced capacity to change the morphology of infected cells. Keywords: ADP-ribosylation; coenzyme binding ... primer pair pexoSa (forward): 5¢-CGGAGAAACTCGAGGAGAAGGCAACCATC-3¢, pexoSb (reverse): 5¢-GTCTTTCTGGTACCACCGGTCA GGCCAGA-3¢. pMF419 and pMF420 were obtained by replacing the C-terminal...

Ngày tải lên: 31/03/2014, 08:20