Báo cáo khoa học: M1 – Peptidomimetics and Signal Transduction Inhibition potx

... potent Abstracts 538 M1 – Peptidomimetics and Signal Transduction Inhibition M1 001 Tricking cancer cells to die A. Levitzki Unit of Cellular Signaling, Department of Biological Chemistry, The Alexander Silberman, ... movens’’ of Ab 1–4 2 toxic- ity. In fact, both Ab 1–4 0 and 1–4 2 have been shown to form ion channels in planar bilayer membranes.[1, 2] Besides, Ab 1...

Ngày tải lên: 30/03/2014, 20:20

... to 0.5% final con- centration and heating at 95 °C for 5 min. Streptavidin sepharose beads (25 lL; GE Healthcare) and 500 lLof 100 mm Tris–HCl (pH 8.0) were added and incubated for 30 min at 4 ... (S235 ⁄ 236), S6 kinase and phospho-S6 kinase (T389) (Cell Signaling Technology, Beverly, MA, USA); S6 (Bethyl Laboratories, Montgomery, TX, USA); b-actin and GST-tag (Sigma); and His-tag...

Ngày tải lên: 06/03/2014, 00:21

Ngày tải lên: 23/03/2014, 16:20

... amyloliquefaciens and primers V1, V 2, and V 3 (Table 2) for regions MKKRFWFLA, VFIDYKVEG, and IVGVISDAE of the B. subtilis Sip V protein were chosen and found to generate PCR fragments of about 0.5 and 0.4 ... bout physiological and g enetic peculiarities [29]. In previous studies, two SipS-like signal peptidases SipS1(ba) and SipS2(ba)ofB. amyloliquefaciens were described [3...

Ngày tải lên: 21/02/2014, 03:20

... hypothala- mus–pituitary–adrenal axis in humans. Math Med and Biol 22, 1 5–3 3. 3 Michaelis L & Menten M (1913) Die Kinetik der Invertinwirkung. Biochem Z 49, 33 3–3 69. 4 Cleland WW (1963) The ... September 2009) doi:10.1111/j.1742-4658.2009.07382.x The temporal aspects of signaling are critical to the function of signals in communications, feedback regulation and control. The pr...

Ngày tải lên: 07/03/2014, 00:20

... finding that TGA factors from Arabidopsis, tobacco and rice have been shown to interact in vivo and in vitro with NPR1/ NIM1 [2 7–2 9,32,33]. NPR1/NIM1 has been identified as a key regulator of SAR ... Arabidopsis. Plant Cell 15, 184 6–1 858. 4886 R. Gru ¨ ner et al.(Eur. J. Biochem. 270) Ó FEBS 2003 Salicylic acid and the hypersensitive response initiate distinct signal transducti...

Ngày tải lên: 23/03/2014, 15:21

... site between Gly36–His37, whereas the self- cleavage occurred at multiple sites in the absence of phospholipid, and two additional self-cleavage sites, Ala65–His66 and Ala143–Phe144, were identified. ... sequences obtained from five cleaved protein bands were summa- rized in Table 1. In the absence of phospholipid, three self-cleavage sites, Gly36–His37, Ala65–His66, and Ala143–Phe144 wer...

Ngày tải lên: 23/03/2014, 21:21

... regulation and/ or direct inhibition of cell death machinery. Keywords: apoptosis; MAP-kinase; neurons; neuropro- tection; programmed cell death; signal transduction; survival. Signaling pathways and ... extracellular signal regulated kinases 1 and 2 in neuronal survival Michal Hetman 1,2,3 and Agata Gozdz 1 1 Kentucky Spinal Cord Research Injury Center and Departments of Neu...

Ngày tải lên: 30/03/2014, 14:20

... compound as radioligand and competitor. Trends Pharmacol Sci 10, 22 7–2 29. 23 Klotz IM (1982) Numbers of receptor sites from Scatchard graphs: facts and fantasies. Science 217, 124 7–1 249. 24 Bennett ... ligands. Application to drugs, hormones, and neurotransmitters. Mol Pharma- col 15, 6 0–7 0. 42 Stoker MG (1973) Role of diffusion boundary layer in contact inhibition of grow...

Ngày tải lên: 14/02/2014, 14:20

... Friedlander AM (1996) Recombinant V antigen protects mice against pneumonic and bubonic plague caused by F1-capsule- positive and -negative strains of Yersinia pestis . Infect Immun 64, 458 0–4 585. 75 ... III intoxication and lung injury. Nat Med 5, 39 2–3 98. 76 Une T & Brubaker RR (1984) Roles of V antigen in promoting virulence and immunity in yersiniae. J Immunol 133, 222...

Ngày tải lên: 14/02/2014, 22:20