Báo cáo khoa học: Organelle and translocatable forms of glyoxysomal malate dehydrogenase The effect of the N-terminal presequence pot
Báo cáo khoa học: Organelle and translocatable forms of glyoxysomal malate dehydrogenase The effect of the N-terminal presequence pot
... through the organelle membrane [10–12]. If so, the relative stability of the two forms of the enzyme comes into question.Here the stability of the translocatable and the mature forms of the MDHs ... structure of the precursor and mature forms of the novel glyoxysomal MDH aswell as the steady state parameters, the quaternarystructure and the thermal stability of the two forms. Results The experiments ... veri-fied the presence of the presequence. To compare the quaternary structure of the two forms of the enzyme, dynamic light scattering was usedwith the results shown in Fig. 3. Both the mature and translocatable...
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Báo cáo khoa học: "GRAMMIATICAL AND UNGRAMMATICAL STRUCTURE SINUSER - ADVISER DIALOGUES1 EVIDENCE FOR SUFFICIENCY OF RESTRICTED LANGUAGE SINNATURAL LANGUAGE INTERFACES TO ADVISORY SYSTEMS." potx
... discourse. The difference in number of occurrences per I000 words between the Wizard -of- OZ con- dition and the Informal Spoken condition is much less than the same difference between the Wizard -of- OZ ... record of tAc li~ting of the names of the features). At least 50,C/o of the ,:set-adviser utterances had one or more prepositional phrases ks can be seen in Table 4, most of the structurally ... to NPs rather than VPs and moreover attach most often to the lowest, nearest NP is important for the semantic interpreta- tion of sentences because of the combinatorial explosion of possible...
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Báo cáo khoa học: Saporin and ricin A chain follow different intracellular routes to enter the cytosol of intoxicated cells pptx
... isoforms can be found inseeds and leaves of the soapwort Saponaria of cinalis and some have been expressed in Escherichia coli and characterized biochemically [18,19]. The catalyticsubunits of ... 4985 of intoxication. Neither the human leukemic cell lineHSB-2 nor the Burkitt lymphoma Ramo cells showedany potentiation of cytotoxicity by addition of the KDEL sequence to the C-terminus of ... [10–12] and weretherefore used to compare the cytotoxic activities of the recombinant polypeptides (Table 2). The KDELsequence increased the cytotoxicity of RTA almost20-fold (ID50 of 1.8...
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Báo cáo khoa học: Adeno-associated virus gene transfer in Morquio A disease – effect of promoters and sulfatase-modifying factor 1 pot
... approach, and there have been a number of clinical and experi-mental studies. The success of a gene therapy protocoldepends on the selection of the candidate disease, tar-get cell, promoter region and ... instability and production of the target protein[43,44]. The results presented in this work agree withprevious reports showing that the inclusion of a syn-thetic intron and the use of the bovine ... indicate that secretion of GALNS and the effect of SUMF1 coexpression areaffected by cell type, and also demonstrate the impor-tance of defining the optimal ratio of sulfatase and SUMF1 genes.Bone...
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Báo cáo khoa học: Expression and characterization of soluble forms of the extracellular domains of the b, c and e subunits of the human muscle acetylcholine receptor pot
... of the 3D structure of the receptor ECDs and for the characterization of the specificities of antibodies in sera from patients with MG. Weexpressed the N-terminal ECDs of the b (amino acids 1–221; ... subunit and the c ⁄ e subunits and the other between the seconda subunit and the d subunit [4]. The c ⁄ e and d subunitsplay a major role in shaping the ligand-binding sites and also in maintaining ... report, we present the expression and charac-terization of the ECDs of the b, c and e subunits of the human muscle AChR. We describe their expressionin a soluble, glycosylated form and in satisfactoryamounts...
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Tài liệu Báo cáo khoa học: Applications and trends in systems biology in biochemistry docx
... developments on the theoretical sidelayed the foundation of the field, such as metaboliccontrol analysis [4,5] and biochemical systems theory[6]. In the 1980s, the development of extreme currents and elementary ... indescribing and interpreting the effects of ethanol stress. Inparticular, the ratio between the kinetic constants associated withethanol production and glucoseconsumption gave the estimation of the ... Net flux of glucose through the oxidative PPP accounts for close to10% of the total hexose influx. The reductant produced by the oxidativePPP accounts for at most 44% of the NADPH and 22% of totalreductant...
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Tài liệu Báo cáo khoa học: Structure and function of active chromatin and DNase I hypersensitive sites pdf
... C (1989) The limits of the DNase I-sensitive domain of the human apolipoproteinB gene coincide with the locations of chromosomalanchorage loops and define the 5¢ and 3¢ boundaries of the gene. ... Since then there has been an explo-sion of papers on the multitude of chromatin modifica-tions and the factors that can either create orrecognize them. We now have a very detailed picture of the ... Hence, the maintenance of a condensed chromatin structure throughout the entire body of a gene may rely on the combinedactions of Set3 at the 5¢ end and Set2 at the 3¢ end.In yeast the cycle of...
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Tài liệu Báo cáo khoa học: miRNAs and regulation of cell signaling pptx
... grantsfrom the Scientific Fund of the Ministry of Education,Science and Culture of Japan (G.T.); the Program forPromotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical ... regulation of signal cascades and the physiological and pathological roles of miRNAs. Hence, furtherinvestigations aiming to elucidate the mechanisms and signal cascades that regulate the expression of miRNAs ... stimulates the production of these miR-NAs and thus represses the expression of their targetgenes. TGF-b signaling is known to be involved in the epithelial–mesenchymal transition (EMT). The transcription...
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Tài liệu Báo cáo khoa học: MicroRNAs and epigenetics doc
... ATP-dependent manner [20]. Next, onestrand (the passenger strand) of the miRNA isremoved from the RLC, whereas the other strand (the guide strand) remains in the complex to form amature RNA-induced ... both the BTG4 gene and the miR-34b ⁄ c polycis-toron [28]. Thus, miR-34b ⁄ c expression may beregulated by both the promoter of the host gene and the promoter in the latter CpG island. The methyla-tion ... maintenance of DNA methylation. In addition, some isoforms of DNMT3B are targeted at the penultimate exon of theircoding regions by miR-148 [81]. DNMT3B exhibitsseveral splicing isoforms, of which...
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Tài liệu Báo cáo khoa học: MicroRNAs and cardiovascular diseases ppt
... part of the host defenses against infection and injury, butalso contributes to the initiation and progression of atherosclerosis [103,104]. The response-to-injuryhypothesis proposed that endothelial ... summarize the current understanding of miRNA function in the heart and outline details of what is known about their puta-tive targets. In addition, we review several aspects of the regulation of miR ... representing the most rapidly evolving research field. In the present minireview, the current relevant findings on the role of miRNAsin cardiac diseases are updated and the target genes of these miRNAs...
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