... observed in cells treatedwith cisplatin [50]. Interestingly, expression of geneswith stronger promoters was strongly inhibited,whereas some genes possessing weaker promoters wereinduced. It was ... pPGM4 were used as the sequence-specific competitors, and changes in p53(1–363) binding to the 32P-labeled 50-mer targets were fol-lowed. We first tested the effect of the presence of the competitor ... chromatin domainon the other. Moreover, some of the p53 downstreamgenes possess more than one p53 response element, and these may differ in their susceptibilities to cis-pla-tination (for example,...