Báo cáo khoa học: Fatty acid regulation of adenylyl cyclase Rv2212 from Mycobacterium tuberculosis H37Rv doc

... Rv1625c of Mycobacterium tuberculosis: a progenitor of mammalian adenylyl cyclases. EMBO J 20, 3667–3675. 20 Linder JU, Schultz A & Schultz JE (2002) Adenylyl cyclase Rv1264 from Mycobacterium tuberculosis ... 4219–4228 ª 2006 The Authors Journal compilation ª 2006 FEBS Fatty acid regulation of adenylyl cyclase Rv2212 from Mycobacterium tuberculosis...

Ngày tải lên: 30/03/2014, 10:20

... performed in 30 mL of 2.5 m M of Tris/HCl buffer, pH 7.0 and 0.1 M NaCl. Release of fatty acid was titrated with 0.1 M NaOH. Enzymatic activity was expressed in units (U) per mg of protein where ... identity ranging from 44% to 31%. These structural homologs, which are members of the human HSL protein family, include the thermophilic esterase from Bacillus acidocaldarius [29...

Ngày tải lên: 07/03/2014, 16:20

... of fatty acid predominating in the oil, but also contained a complex mixture of other fatty acids, as occurs in vivo. As might be expected, the fatty acid composition of CRLPs containing TG from ... (SFA), fatty acids decreasing the risk [22]. Our earlier work has shown that the fatty acid composition of chylomicron remnants reflects that of the diet [23], and modul...

Ngày tải lên: 16/03/2014, 12:20

... kinetics of the various mutants. The proposed model for transfer of the acyl chain from ACP to KAS III, a CHN group enzyme, consists of two steps: specific, albeit weak, binding of ACP to the docking ... [25]. The formation of the fatty acid complex is accompanied by the emergence of a well- defined water molecule within hydrogen bond distance of His333 N e (Fig. 3A,B). Stru...

Ngày tải lên: 19/02/2014, 08:20

... of their target genes. Indeed, several examples of feedback regulation that involve miRNAs have been reported. Below, we attempt to summarize our recent understanding of feedback regulation of ... Culture of Japan (G.T.); the Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation Table 1. miRNAs involved in the fe...

Ngày tải lên: 14/02/2014, 19:20

... of very long chain polyunsaturated omega-3 and omega-6 fatty acid in plants. Nat Biotech 22, 1–7. 12 Qiu X, Hong H & MacKenzie SL (2001) Identification of a Delta 4 fatty acid desaturase from ... & Mukerji P (2004) Identification of two novel microalgal enzymes involved in the conversion of the x3 -fatty acid, eicosapentaenoic acid, into docosahexaenoic acid. Bio-...

Ngày tải lên: 20/02/2014, 01:20

... level of inhibition consistent with a physiological role (IC 50 of  120 lm), whereas the worst inhibitors tested were the three acid analogues NAMN, NAAD and nicotinic acid, with IC 50 values of ... C. Smith 2 and John M. Denu 1 1 Department of Biomolecular Chemistry, University of Wisconsin, Madison, WI, USA 2 Department of Chemistry, University of Wisconsin, Madison, WI, U...

Ngày tải lên: 20/02/2014, 01:20

... mechanism of regulation of both domains involves a common iron dependent process [74,75,79]. Regulation of HIFa subunits by oxygen-dependent prolyl and asparaginyl hydroxylation A variety of oxygen ... of regulation by oxygen, it has been the recent analysis of HIF- 1a and HIF-2a protein stability and transactivation potency that have provided the greatest insights into oxyg...

Ngày tải lên: 20/02/2014, 23:20

... subsequent degra- dation of the receptor in transfected human embryonic kidney cells [50]. Direct regulation of the EGFR by CaM The direct regulation of the EGFR upon binding of the Ca 2+ ⁄ CaM complex ... C-terminal lobe of the kinase domain of one of the monomers forming the dimeric receptor interacts with the N-terminal lobe of the apposed monomer [19,47,84]. Of relev...

Ngày tải lên: 06/03/2014, 09:22

... binding of U2AF. The lower panel shows that most of the HIV-1 3¢ss deviate from the consensus because of their low content of pyrimidine nucleotides. A B Fig. 4. Positive and negative regulation of ... the activation of site A3 (25% of the overall activation). Therefore, the most important parameter of site A3 activation is expected to be the displacement of protein hnRN...

Ngày tải lên: 06/03/2014, 09:22