Báo cáo khoa học: Hodgkin Reed–Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo Novel insight into the inflammatory features of classical Hodgkin lymphoma ppt
Báo cáo khoa học: Hodgkin Reed–Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo Novel insight into the inflammatory features of classical Hodgkin lymphoma ppt
... Reed–Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo Novel insight into the in ammatory features of classical Hodgkin lymphoma Hans-Erik Claesson1,2, William ... not expressed in any of 10 biopsies representing nine different subtypes of non -Hodgkin lym-phoma. In essence, the expression of 15-lipoxygenase-1 and the putative formation of eoxins by Hodgkin ... Hodgkin Reed–Sternberg cells in vivo are likely tocontribute to the in ammatory features of Hodgkin lymphoma. These find-ings may have important diagnostic and therapeutic implications in Hodg-kin...
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Tài liệu Báo cáo khoa học: Secondary substrate binding strongly affects activity and binding affinity of Bacillus subtilis and Aspergillus niger GH11 xylanases docx
... of the SBS of XBS, the resultsobtained in the previous screening experiment directlyTable 1. The effect of genetic engineering of the secondary bind-ing site of the B. subtilis and A. niger ... containing (mutant) XBS and on P. pastorisexpression media containing (mutant) XAN. The results of the screening for XBS and XAN with amodified SBS are shown in Table 1.XBS The results of the ... binding play no (or a very minor)role in the hydrolysis of oligomeric substrates. The SBS is located too far from the active site to in uence the binding and catalysis of these substrates in...
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Báo cáo khoa học: A new pathway encompassing calpain 3 and its newly identified substrate cardiac ankyrin repeat protein is involved in the regulation of the nuclear factor-jB pathway in skeletal muscle pdf
... proteinspanning half the sarcomere [3,14,15]. Two of theseregions, the N2A region and the M line, are involved in the transmission of mechanical signals to signaling path-ways. In the M line, ... to be involved in the homodi-merization of CARP [49]. We therefore propose that the loss of CARP dimerization promotes the binding totitin by improving the accessibility of the titin-bindingdomain. ... activates the interaction of a protein complex with the kinasedomain of titin, reducing the nuclear translocation of the transcription factor SRF and impeding gene tran-scription [16]. In the elastic...
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Báo cáo khoa học: Large-scale overproduction, functional purification and ligand affinities of the His-tagged human histamine H1 receptor ppt
... culture media containing0.1% Pluronic F-68.Infection of Sf9 cells Cells were infected with pBac-H1His10 at a multiplicity of infection (MOI) of 0.1. Infected Sf9 cells were maintained in complete ... fitting procedure to determine total and nonspecific binding at the same time. In saturation bindingexperiments the experimentally determined nonspecificbinding was used to estimate nonspecific binding ... detailedstructural and functional information require mg amounts of purified protein. There are several reports claiming a highlevel production of functional GPCRs in insect cells in the range of 2–4 mgÆmL)1after...
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Tài liệu Báo cáo khoa học: Pyruvate reduces DNA damage during hypoxia and after reoxygenation in hepatocellular carcinoma cells pptx
... decreases the level of ROS in the medium of HepG2 cells exposed to hydrogen peroxide. HepG2 cells were incu-bated with 5.5 mM glucose in the presence of 0.8 mM pyruvate, and exposed to increasing ... underlying the pyruvate effects has yet to be further examined. In light of the data in the literature and our workwith HepG2 cells, we concluded that pyruvate mightact similarly in tumor cells and ... enhances the expression of c-glutamylcysteinesynthetase [14] and glutathione transferase [15] in can-cer cells. Such alterations of the glutathione systemcan enhance survival of cancer cells. In...
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Tài liệu Báo cáo khoa học: Cell surface heparan sulfate proteoglycans Target and partners of the basic ®broblast growth factor in rat Sertoli cells pptx
... sequences of HS chains are de®ned for the bFGF binding and for the recognition of the speci®c bFGFreceptor, leading to the formation of a ternary complexcomprising HSPG±bFGF±FGFR. These oligosaccharidicmotifs ... compared to cells expressingHSPG [4,11±15].Sertoli cells are the principal source of estradiol produc-tion in the immature testis [16,17]. Signi®cant estrogensynthesis is present in Sertoli cells ... extraction, cells were incubated for 24 heither in the absence or in prese nce of FSH, dbcAMP,cholera toxin or bFGF, either in combination with FSH ordbcAMP or cholera toxin and bFGF.Extraction of...
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Báo cáo khoa học: Recombinant bovine zona pellucida glycoproteins ZP3 and ZP4 coexpressed in Sf9 cells form a sperm-binding active hetero-complex ppt
... that the polypeptide regions involved in the interaction between ZP3 and ZP4 are highly conserved in cows and pigs. The porcine and bovine rZPGs may be useful forobtaining new insights into ... mixture for 30 min and thenincubated with bovine eggs. The inhibitory effects of the proteinswere determined by Method 2. The number of sperm binding toeggs in the absence of inhibitors is designated ... Hetero-com-plexes of bovine rZP3 and porcine rZP4, or porcine rZP3 and bovinerZP4, also inhibited bovine sperm–ZP binding. Our results demonstratethat the N-terminal and trefoil domains of bovine rZP4 are...
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Báo cáo khoa học: Hansenula polymorpha pex11 cells are affected in peroxisome retention potx
... on the peroxisomes that are retained in the mother cells. In pex11 cells, Inp1–GFP is localized to peroxisomesindependently of whether they are transported into the bud. In wild-type cells, Inp1–GFP-containing ... stages, the levels of Inp1–GFP fluorescence are below the level of detection (0 and 60 min). At the initial stages of budding,fluorescence is markedly increased on the peroxisome to be retained in the ... pex11 cells. The data pre-sented in Fig. 4B show that in inp1 cells a significantpercentage of the budding cells lacked peroxisomes in the mother cells under conditions in which wild-typecells...
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Báo cáo khoa học: Pituitary adenylate cyclase-activating polypeptide attenuates streptozotocin-induced apoptotic death of RIN-m5F cells through regulation of Bcl-2 family protein mRNA expression pdf
... [2]. The biochemical features of apoptosis include the activa-tion of one or more cysteine proteases of the caspasefamily [23]. To examine the possible involvement of caspase-3 in the STZ-induced ... STZ-induced oxidative stress in several tissues and cells [19,20].Results and DiscussionCytotoxicity of streptozotocin in RIN-m5F cells In the present study, we initially investigated the earlymechanisms ... respectively, in the expression of Noxa and Bax mRNA compared to STZ alone.PACAP38 could also attenuate STZ-evoked expression of Noxa mRNA by 36%, and the expression level of Bax mRNA in the presence of...
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Tài liệu Báo cáo khoa học: Amprenavir complexes with HIV-1 protease and its drug-resistant mutants altering hydrophobic clusters docx
... different inhibitors will give insight into the mechanisms of resistance and help in the design of new inhibitors.ResultsAPV inhibition of PR and mutants The kinetic parameters and inhibition ... to the carbonyl of Gly27 and the amide of Asp29 and a H2OÆÆÆp interaction with the ani-line group of APV. The interactions of H2OB are con-served in PR complexes with DRV and antiviralinhibitors ... with the side chains of Val56,Leu76 and the main chain atoms of residues 77–78, and Ile32¢ showed new interactions with the side chains of Ile47¢, Ile50 and Val56¢ in the flaps (Fig. 3A). The flaps...
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