Báo cáo khoa học: Hypoxia-driven proliferation of embryonic neural stem ⁄ progenitor cells – role of hypoxia-inducible transcription factor-1a ppt

... compilation ª 2008 FEBS Hypoxia-driven proliferation of embryonic neural stem ⁄ progenitor cells – role of hypoxia-inducible transcription factor-1a Tong Zhao 1, *, Cui-ping Zhang 1, *, Zhao-hui ... the growth of most kinds of cells, promote the proliferation of some types of cells. There is increasing evidence that mild hypoxia acts as a potent r...

Ngày tải lên: 30/03/2014, 04:20

... loss -of- function mutations in the predominantly neuronal P-type ATPase gene ATP13A2 are the cause of Kufor–Rakeb syndrome [33]. The clinical features of Kufor–Rakeb syndrome are similar to those of ... the brainstem nuclei and cerebral cortex [23]. PLA2G6 belongs to the family of A 2 phospholipases, which catalyze the release of fatty acids from phospholipids and play a role in...

Ngày tải lên: 18/02/2014, 14:20

... selection of residues: 2 6–1 21 and 32 5–3 43 (chain A), 26 6–2 95 (chain B) and 38 5–3 99 (chain C) in SmPAL out ⁄ in and 3 3–1 28 and 33 3–3 51 (chain A), 27 2–3 03 (chain B) and 29 3–3 06 (chain C) in PlPAL out ⁄ ... on the following selection of residues: 5 0–1 80 and 38 0–3 98 (chain A), 32 9– 350 (chain B), 44 0–4 55 (chain C) by Amber99 force-field...

Ngày tải lên: 07/03/2014, 12:20

... regulation Role of the lipoate residues and thioredoxin Victoria I. Bunik A.N.Belozersky Institute of Physico-Chemical Biology, Moscow State University, Russia A number of cellular systems cooperate ... Redox state of the complex-bound lipoate is an indicator of the availability of the reaction substrates (2-oxo acid, CoA and NAD + ) and thiol-disulfide status of the medium. Ac...

Ngày tải lên: 17/03/2014, 09:20

... Mu ¨ ller cells. Previous evidence has suggested that CRALBP is expressed in both the RPE and Mu ¨ ller cells of mammals [31,32]. In addition, it was reported that CRALBP-b, an isoform of CRALBP, ... Biochemi- cal characterization of the retinoid isomerase system of the eye. J Biol Chem 262, 1684 8–1 6857. 6 Bernstein PS, Law WC & Rando RR (1987) Isomeriza- tion of all-tra...

Ngày tải lên: 14/02/2014, 14:20

... deregulation of EGFR signaling is com- monly associated with stimulation of ERK1 ⁄ 2 and Pak1 pathways, gefitinib might lead to inhibition of invasiveness of human cancer cells through the inhibi- tion of ... inhibitors of the cyclin D–CDK4 ⁄ 6 complex It is not yet known if EGFR-TKIs can stop G 2 transition and G 2 ⁄ M cell-cycle progression by up-regulation of KIP...

Ngày tải lên: 16/02/2014, 09:20

... 1100 HPLC system. Elution was performed by application of the solvent gradient of water ⁄ 0.05% formic acid (solvent A) and methanol ⁄ 0.05% formic acid (solvent B) at a flow rate of 16 mLÆmin )1 : ... resuspension of the cells in the target medium. Subsequently, the cells were used to inoculate 5 L of iron-deficient M9 medium in PC-flasks until D 600 of 0.01 was reached....

Ngày tải lên: 16/02/2014, 09:20

... level of HSS-expressing cells fell to a low level, the relative amount of ATP in HSS- expressing cells was about 45% higher than that in vector-transfected cells, suggesting that HSS-expressing cells ... (pcDNA3.0 alone) or wild-type cells (Fig. 1A). Protein expression of HSS in the three cell lines (untransfected cells, vector-transfected cells, and HSS-expressing cells) w...

Ngày tải lên: 16/02/2014, 09:20

... Department of Medicine, Harvard Medical School, Division of Rheumatology, Immunology, and Allergy, Brigham and Women’s Hospital, Boston, MA, USA 3 Laboratory of Molecular Function of Food, Division of ... error of the mean; TG, transgenic; WAT, white adipose tissue. 1410 FEBS Journal 277 (2010) 141 0–1 419 ª 2010 The Authors Journal compilation ª 2010 FEBS and size of adipocyt...

Ngày tải lên: 16/02/2014, 09:20

... consists of four dif- ferent subfamilies designated MT1 to MT4 [ 2–4 ]. Mammalian MTs are composed of a single polypep- tide chain of 6 1–6 8 residues. They are characterized by a conserved array of 20 ... additional eighth equivalent of Zn(II) or Cd(II). Binding of more Zn(II) ⁄ Cd(II) is very likely to be non-specific. Whether the binding of seven equivalents of Zn(II...

Ngày tải lên: 16/02/2014, 15:20