Báo cáo khoa học: Transcription factors Sp1 and C⁄EBP regulate NRAMP1 gene expression ppt

... Sp1 and C ⁄ EBP regulate NRAMP1 transcription FEBS Journal 275 (2008) 5074–5089 ª 2008 The Authors Journal compilation ª 2008 FEBS 5089 Transcription factors Sp1 and C ⁄ EBP regulate NRAMP1 gene ... that C ⁄ EBP and Sp1 factors regulate NRAMP1 expression during myeloid differentiation. Discussion This study identified cis-acting sequences in the NRAMP1 pro...

Ngày tải lên: 30/03/2014, 02:20

... acid synthase by pharma- cologic or genetic means leads to an increased malonyl-CoA level and sup- pression of food intake and adiposity. Conversely, the ectopic expression of malonyl-CoA decarboxylase ... hypothalamus is sufficient to pro- mote feeding and adiposity. Based on these and other findings, metabolic intermediates in fatty acid biogenesis, including malonyl-CoA and long-...

Ngày tải lên: 14/02/2014, 22:20

... regulation and expression, as full-length and truncated isoforms of di-, mono- and nonglycosylated proteins are only detect- able with antibodies recognizing the C-terminal region and produce altered expression ... SAF34 and P4 strongly stained the di-glycosylated band, and mAbs 6H4, SAF60, SAF70 and SAF84 showed the highest staining with the overlapping bands of nonglycosyla...

Ngày tải lên: 19/02/2014, 02:20

... derivation trees. M-GENERATOR(d) = ~,.f { t I 3b• B:d=b andt=b } U { t ] 3tl, ,t., dl d.,Ri: d = R,<dl, ,d.> and t~ • M-GENERATOR(dl) and t. • M-GENERATOR(d.) and t • F,'(tl ... ce = [ce, l and ((D~ = D and u = t and A = false) or (D2, u, true) • CF_,-PARSER(GI, ce,, D, t) and A = true) } U { (D~, u, A) I B ce,: ce = {ce,} and ((D~ = D and u =...

Ngày tải lên: 22/02/2014, 10:20

... D-strand into two halves. Middle: cartoon representation of the D53P mutant with a shorter D-strand and an extended and protruding CD loop. Right: monomeric wild-type b2m displays a regular D-strand. ... MHC I (MHC) and the secondary structures of fibrillar b2m (AMY) predicted by Debelouchina et al. [19]. b-strands C, D and E are labeled as ssC, ssD, and ssE, respectively. The CD an...

Ngày tải lên: 06/03/2014, 00:20

... Pattern dairy and meat English: production of dairy and meat h of w 1 and w 2 production English: dairy production and meat production w 1 h and w 2 h (ellipsis) English: meat and dairy production w 2 and ... meat asbestos and English: polyvinyl chloride and asbestos w 2 h and w 1 polyvinyl English: asbestos , and polyvinyl chloride w 1 , and w 2 h chloride English: as...

Ngày tải lên: 17/03/2014, 00:20

... between ROUGE and human evaluation of extractive meeting summaries and focus on two issues specific to the meet- ing domain: disfluencies and multiple speakers. Both human and system generated summaries ... Infor- mative Coverage (IC): S2 and S9; Informative Relevance (IRV): S3 and S8; and Informative Redundancy (IRD): S4 and S7. 4 Results 4.1 Correlation between Human Evaluatio...

Ngày tải lên: 17/03/2014, 02:20

... cofactors are generally employed by enzymes to enable a wide and diverse range of biochemical transformations necessary for all aspects of life. Some of these cofactors, such as vitamin B 12 and ... FMN and FAD is based on their redox-active isoalloxazine ring system, which is capable of one-electron and two- electron transfer reactions and, most importantly, of dioxygen activation [...

Ngày tải lên: 28/03/2014, 22:21

... mut and P Sp1 proximal mut (Table 1) were used for site-directed mutagenesis with the GeneEditor site-directed mutagenesis kit (Promega), according to the supplier’s pro- tocol. Transfection and ... Hercules, CA, USA). The oligonucleotide primers P ORE ,P ORE mut , P Sp1 ,P Sp1 mut ,P Sp1 19bp ,P Sp1 19bp mut and Punspecific com- petitor, and the 15 primer mixes containing mu...

Ngày tải lên: 30/03/2014, 03:20

... 46.9%, whereas overexpression of Sp1 increased the promoter activity by 58.3%. The expression of endogenous KCTD10 was downregulated 1.9-fold by Sp1 silenc- ing, and upregulated 12.0-fold by Sp1 overexpression. Western ... bound the Sp1 or AP-2a sites, and worked in the basal state to regulate KCTD10 transcription, respectively. Roles of Sp1 and AP-2a in the regulation of...

Ngày tải lên: 30/03/2014, 02:20