Báo cáo khoa học: Galanin-like peptide and the regulation of feeding behavior and energy metabolism pptx

... MINIREVIEW Galanin-like peptide and the regulation of feeding behavior and energy metabolism Kanako Shiba1, Haruaki Kageyama1, Fumiko Takenoya1,2 and Seiji Shioda11 Department of Anatomy, ... in feeding and energy metabolism FEBS Journal 277 (2010) 5006–5013 ª 2010 The Authors Journal compilation ª 2010 FEBS 5009Effect of GALP on feeding behavior and energy metabolism Galanin and ... neurons project from the ARC to the PVN, and the other in which they project to the MPA, bed nucleus of the stria terminalis and lateralseptal nucleus.Central administration of GALP activates...

Báo cáo khoa học: Thyroid hormone induces the expression of 4-1BB and activation of caspases in a thyroid hormone receptor-dependent manner pptx

... the HeLaTR cells transfected with 4-1BBcDNA, and the 4-1BB-Ligand further increased the caspaseactivities of the HeLaTR cells overexpressing the 4-1BB.Furthermore, up -regulation of 4-1BB and ... Proliferation of the cells was also impairedin the presence of T3, though the degree of the inhibition of proliferation by T3 was rather weak (Fig. 5C).According to the results of DNA microarray and RT-PCR, ... 6A). As in the HeLaTR cells, T3 treatment of the FRTL cells signiﬁcantlyincreased the level of the 4-1BB mRNA and decreased the level of the BMP6 mRNA. Furthermore, a marked increasein the Z-VAD-FMK-sensitive...

Báo cáo khoa học: "Shallow parsing on the basis of words only: A case study" pptx

... consists of the val-ues for all features (the columns) and the function-chunk code for the focus word. The features de-scribe the focus word and its local context. For the chunk part of the code, ... adopt the “Inside”,“Outside”, and “Between” (IOB) encoding originat-ing from (Ramshaw and Marcus, 1995). For the function part of the code, the value is either the function for the head of a ... .”stances and , ,where is the number of features, is a weight forfeature , and estimates the difference between the two instances’ values at the th feature. The classes of the nearest neighbors then...

Báo cáo khoa học: "SOFTWARE TOOLS FOR THE ENVIRONMENT OF A COMPUTER AIDED TRANSLATION SYSTEM" pptx

... questions to each node and the possible answers to the arcs coming from a node ; the leaves of the tree bear the name of the code and an example. A language to write the "indexing charts" ... ATLAS are the following : - Editing and updating of indexing charts : compi- lation of an external form of the chart, and modification of the internal form through inte- raction with the user, ... that the user can traverse the charts answering the questions. He can also view the code found, or any other code, by request, and examine and update the dictionary by writing the code in the...

Báo cáo khoa học: On peptide bond formation, translocation, nascent protein progression and the regulatory properties of ribosomes ppt

... (called here the Ôinner strandsÕ) and the A- and the P-loops (that are the stem loops of helices H80 and H92). The second (middle) shell includeshelices H80 and H92, the stems of the A- and the P-loops,H74 ... rotation of  180° of the 3¢ end of the A-site tRNA, performed in conjunction with peptide bondformation, and the shift of the acceptor stems of the tRNA. Sovereign motions of structural features of ... nucleotidesrestrict the possible motions of the RM nucleotides and limit their ﬂexibility. The formation of the peptide bond The most signiﬁcant biological implication of the two-foldrotation of the tRNA-3¢...

Tài liệu Báo cáo khoa học: MicroRNA-23a promotes the growth of gastric adenocarcinoma cell line MGC803 and downregulates interleukin-6 receptor pdf

... on the expression of IL6R by RT-PCR and western blot, and found an inverse correlation between miR-23a and IL6R expression at both the mRNA and protein levels.To conﬁrm the direct regulation of ... Institute and Hospital and the National Foundation of Cancer Research. All of the tumor types were conﬁrmedby pathologic analysis. The experiments were undertakenwith the understanding and written ... containing the mutations of the miR-23a binding site (Fig. 4A). It was shown thatmiR-23a ASO or pcDNA3 ⁄ pri-23a did not affect the intensity of EGFP ﬂuorescence in the vector bearing the mutant of the...

Tài liệu Báo cáo khóa học: Further insights into the assembly of the yeast cytochrome bc1 complex based on analysis of single and double deletion mutants lacking supernumerary subunits and cytochrome b pdf

... 7. The arrowslabeled (b) and (c) point to the areas of interaction between the transmembrane helix of subunit 8 and helices G and H1 of cytochrome b and between the N-terminus of subunit 8 and ... panels A and B and the relative amounts of each of the subunits determined by densitometry scanning of the stained Westernblots of the q° and CKL57 membranes are shown in panels C and D, respectively.Ó ... absence of subunit 6 also resulted in anincrease in the ratio of intermediate to mature cyto-chrome c1 and a disappearance of the intermediate form of the Rieske protein. At the same time, the...

Tài liệu Báo cáo khoa học: Adaptive changes in the expression of nuclear and mitochondrial encoded subunits of cytochrome c oxidase and the catalytic activity during hypoxia pptx

... switch and alters the expression of the twonuclear genome coded isoforms of CytOX V [10,32]. The regulation of genes CytOX5a and CytOX5b, coding for the two isofoms Va and Vb, parallels that of ... shows the effects of hypoxia on the steadystate levels of nuclear genome encoded CytOX IV and VbmRNAs. There was no change in the levels of these mRNAsin macrophages at 6 h of hypoxia, the time ... (CytOX) is the terminal oxidase of the mitochondrial electron transport chain [1–5], whichcatalyzes the reduction of the dioxygen (O2) to water and harnesses the free energy of the reaction...

Báo cáo khoa học: Limited mutagenesis increases the stability of human carboxypeptidase U (TAFIa) and demonstrates the importance of CPU stability over proCPU concentration in down-regulating ﬁbrinolysis doc

... similar Kmvalues of the native and WT, and the YQ mutant CPU with a synthetic and physiologicalsubstrate of CPU. There seem to be no major changesin the positioning of the propeptide, as indicated ... CPU at 37 °C and using the same protocol as used in the primary screeningdescribed above.Determination of the half-life (T1/2) of CPU’sactivity The T1 ⁄ 2 of the activity of the best mutants ... on the basis of their model of humanCPU, that the two consecutive I at positions 204 and 205 are exposed to the surface, and because they arequite unique to CPU, might be of importance for the process...

Báo cáo khoa học: Microcin J25 induces the opening of the mitochondrial transition pore and cytochrome c release through superoxide generation doc

... presence of calcium.DiscussionUnderstanding the mechanisms of action of some types of proteins and peptides on the structural and func-tional state of mitochondria seems to be important in the ... of the calcium uniport and MTP respectively, toinhibit the increase of ROS strongly supports the above-mentioned hypothesis. The NADPH oxidationoccurs prior to the opening of the MTP pore and ... MTPmediated by the uptake of calcium through the uniport of calcium. On the other hand, KCN and antimycin A,both inhibitors of electron transport, also inhibited the swelling induced by MccJ25. The inhibition...

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