Báo cáo khoa học: Importance of the gating segment in the substrate-recognition loop of pyranose 2-oxidase pptx

... promoting an increase in proopiomelanocortin and cocaine and amphetamine regulated transcript. Taken together, these findings provide a compelling argument for the role for malo- nyl-CoA in regulating ... and certain amino acids [16]. A linkage between fatty acid synthesis in the CNS and feeding behavior was uncovered with the finding that systemic or intracerebroventricular adminis...

Ngày tải lên: 14/02/2014, 22:20

... from the other bran- ches, which was indeed predicted. The other main group, obtained 97% of the time in 20 740 explored trees, contained the DIDO PHD sequences clustered with the PHF and the ... analyses The localization of the DIDO1 gene in the context of chromatin stability was addressed experimentally. Although the experiments conducted were preliminary, they...

Ngày tải lên: 07/03/2014, 21:20

... stability for crystallins is essential in maintaining lens transparency [4]. Determining the mechanism of folding and assembly of these proteins is important for understanding how they can form stable ... concentrations. The d 2 -crystallin in lens was recruited during evolution from argininosuccinate lyase, an enzyme involved in arginine biosynthesis derived from the urea cyc...

Ngày tải lên: 08/03/2014, 08:20

... chain is brefeldin A-insensitive and is inhibited by the proteasome inhibitor clasto-lactacystin b-lactone, resulting in the accumulation of ricin A chains. These stabilized ricin A chains are partly deglycosylated ... pivotal role of the UPR is to maintain ER home- ostasis. Therefore, the presence of mutated proteins that are unable to fold into their native conformation in...

Ngày tải lên: 16/03/2014, 11:20

... staining of the gel indicates that the fluorescing protein is one of the major components of soluble proteins in the crude extract. The surface of the fluorescing protein carries negative charge in ... cellular retinal-binding protein; CRBP, cellular retinol-binding protein; IRBP, interphotoreceptor retinoid-binding protein; RBP, retinol-binding protein. Note: The nucl...

Ngày tải lên: 17/03/2014, 03:20

... Rather, the advantage appears to depend on the ability of the lipoyl group to protrude from the inner core of the complex, indicative of the biological significance of the complex-bound lipoate interaction ... In view of the redox-sensing function of the lipoate/dihydrolipoate couple of the complex (Fig. 3) and the intimate link between this couple and E1,...

Ngày tải lên: 17/03/2014, 09:20

... strains to obtain the new strains reported in Table 1. Genomic HA-tagging of SDH1 Three consecutive copies of the HA epitope were fused to the 3¢-end of the SDH1 ORF in the genome of both the WT ... for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72, 248–254. 55 Laemmli UK (1970) Cleavage o...

Ngày tải lên: 23/03/2014, 07:20

... by decreasing the rate of cleavage between the two subdomains of the A domain. These findings were later explained with the structural model that the smaller subdomain A C of the A domain rotates ... consisted of the first two functional domains, namely the phenylalanine- specific A domain and the PCP domain. The terminal E domain was excised (the exact amino acid co...

Ngày tải lên: 29/03/2014, 08:20

... were raised in rabbits against a GST-War1p fusion protein containing 294 amino acids of the C-terminal part of War1p (amino acids 650– 944) fused in- frame to the C-terminus of GST. The gene fusion ... DNA-binding zinc cluster at the N-terminus, whereas the acidic activation domain is usually present at the C-terminus. The mid- dle homology region (MHR) bridging the D...

Ngày tải lên: 19/02/2014, 00:20

... defining the set of items that have ever been the actor in a flight. Their definition is solely within NIKL using the QUA link [14], which is exactly the set of fillers of a slot. While having ... expressions in inten- sional logic. 3 4. Use of the Taxonomy in Janus By domain mode/we mean the set of axioms en- coded in NIKL regarding the constants. The...

Ngày tải lên: 21/02/2014, 20:20