... and the cytoplasm. Whereascytoplasmic TRADD mediates apoptosis throughFADD and caspase-8 activation, nuclear TRADD actsthrough a mitochondrial apoptosis pathway [28].Our study provides, for ... nuclear FADDand its nuclear–cytoplasmic translocation? FunctionalDISC assembly and activation of caspase-8 is generallyconsidered to be a ‘point of no return’ in the apoptoticsignaling cascade. ... signals does FADD relocalize to thecytoplasm, promoting CD95–FADD association, whichin turn leads to DISC assembly, caspase-8 activation,and apoptotic cell death. In addition, nuclear FADDmay...