Báo cáo khoa học: Tec family kinases: Itk signaling and the development of NKT ab and cd T cells potx

... regulated by Itk. Depiction of the signaling pathway used by the TCR and modulated by Itk that results in the development of i NKT ab and cd T cells. Note that in the case of the TCR, these pathways ... of Itk in the development of i NKT and NKT- like cd T cells. During T- cell development in the thymus, cd T cells separate fr...

Ngày tải lên: 28/03/2014, 22:21

... be of interest to see the role of the TFKs in regulating the differentiation of this subset. Together, these studies suggest that the TFKs, par- ticularly Itk, but also Rlk ⁄ Txk, play influential ... periphery, but also regulate the development of distinct innate-type cytokine-producing T- cell populations in the thymus. Together, these results suggest that the Tec...

Ngày tải lên: 28/03/2014, 22:21

... 2005 ITK SYK, but not ITK or SYK themselves, is capable of transforming NIH- 3T3 cells [70]. In addition, we and others have demonstrated that the activation and plasma membrane localization of the ... interaction with signaling partners. The remaining mutations alter amino acids located outside the ligand-binding pocket and reduce protein stability. The two patient...

Ngày tải lên: 14/02/2014, 18:20

... IL-4 production which is enhanced in the absence of Btk), the role of Itk and Tec is more specialized and in part also distinct to the role of Btk. The observation that Itk- deficient mast cells display ... utilization of Tec and Btk in the regulation of IL-4 production. The reason for the differential requirement of Tec and Btk is not known and i...

Ngày tải lên: 28/03/2014, 22:21

... (pSL3) and two-fold over the vector con- taining the EMCV IRES (Fig. 5B). The IRES activity of the bicistronic vector with the antisense leader was two times less than that of the one with the sense ... the alternative sGC b2 5¢-UTR had IRES activity. The IRES activity in this sequence was six-fold stronger than that in the full- length and most abundant 5¢-UTR. Th...

Ngày tải lên: 23/03/2014, 07:20

... 1523 mutational studies with the aim of elucidating the rea- sons for the great stability differences between the two enzymes. Extensive thermal inactivation studies have revealed that mutations ... concentrations of < 5 m, unfolding is suggested to be the rate-limiting step for autoproteolysis. In contrast, at GdnHCl concentrations of > 5 m, the extent of autoproteo...

Ngày tải lên: 19/02/2014, 17:20

... next. At each process time interval, there are six types of serial-order process that can occur and affect the state of the process. The most important aspect of the control is that all of the ... given by the overall activation state of the "network" representation within the system at a moment in time. Furthermore, this means that unless activation...

Ngày tải lên: 21/02/2014, 20:20

... be to use it to train a Statis- tical MT system. Three functionalities are needed to carry out this process: acquisition of the data, its alignment and its conversion into the desired format. These are ... or not. The quality of the tools is not altered as they are deployed as WSs without any modification. According to the eval- uation of the current version of the plat...

Ngày tải lên: 22/02/2014, 03:20

... expression. Moreover, the high stability of the 2 h half-life mRNA suggests that high SsSOD levels are likely to protect the cells from the superoxide anion generated in the natural oxidant environment of S. ... from the S. solfa- taricus P2 genome: we report on the cloning of bcp1, bcp3 and bcp4 and the characterization of the recombi- nant products and, next...

Ngày tải lên: 07/03/2014, 05:20

... arginine residue) and overcomes the technical limitations of ICAT-based approaches [15]. Although the possibility cannot be excluded that trypsin treatment of MDCK cells may activate other proteases in the ... Coomassie stain was used that lacked the sensitivity of our house-made fluorescent dye [14]. The improved detection sensitivity of Ruthe- nium staining helped to id...

Ngày tải lên: 07/03/2014, 06:20