Psychiatric and Cognitive Disorders in Parkinson’s Disease pptx
Psychiatric and Cognitive Disorders in Parkinson’s Disease pptx
... of interest in activities of daily living, worrying about minor matters, difficulties
in concentration, and loss of energy and libido. He was diagnosed as having PD and major
depression, and ... the psychiatric and cognitive disorders of PD in one single volume.
Most patients with PD are usually cared for by internists and general
practitioners, but the information abo...
Báo cáo khoa học: LRRK2 in Parkinson’s disease: function in cells and neurodegeneration doc
... but in concert with a
number of conserved domains, including a GTPase
domain. Multidomain proteins that encode functional
kinase domains often utilize intrinsic protein kinase
activity distinct ... works
containing interleukin receptor-associated kinase
family. Many of these kinases have clear roles in the
MAPK pathway, and MLK proteins serve as critical
mitogen-activated protein kinase...
Báo cáo khoa học: LRRK2 in Parkinson’s disease: in vivo models and approaches for understanding pathogenic roles pdf
... FEBS
MINIREVIEW
LRRK2 in Parkinson’s disease: in vivo models and
approaches for understanding pathogenic roles
Zhenyu Yue
Department of Neurology and Neuroscience, Mount Sinai School of Medicine, ... cytoskeleton proteins are known
as frequent ‘contaminants’ in the process of searching
binding proteins, the in vivo evidence for the relation-
ship between ROCO proteins and cyt...
Báo cáo khoa học: LRRK2 in Parkinson’s disease: genetic and clinical studies from patients ppt
... onset Parkinson’s
disease and present with the usual typical clinical features. Genetic testing
for G2019S in sporadic late-onset Parkinson’s disease can be considered
in some situations and may ... WD40
domain. Because WD40 domain is involved in mediat-
ing protein–protein interactions, the LRRK2 G2385R
variant may impact on interactions with substrates
and ⁄ or regulator...
The Use of Selected Medicinal Herbs for Chemoprevention and Treatment of Cancer, Parkinson’s Disease, Heart Disease, and Depression
... ashei cultivars, principally containing delphinidin, cyanidin, peonidin,
petunidin, and malvidin, increased apoptosis as determined by DNA fragmenta-
tion and cysteine–aspartic acid protease, caspase-3, ... coronary,
anti -in ammatory, arteries, sedative, tumor
inhibition, antitumor, blood glucose lowering
Anthocyanins: cyanidin, delphinidin,
malvidin, pelargonidin, petunidin, and
peoni...
Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Autosomal-recessive genes in Parkinson’s disease – a common pathway? docx
... kinases
including casein kinase 1, protein kinase A, protein
kinase C [86] and cyclin-dependant kinase 5 [87]. Phos-
phorylation of Parkin by CDK5 may regulate its ubiqu-
itin-ligase activity and therefore ... pool of PINK1 has been
described [16,17]. PINK1 is of great interest to
research into mitochondrial dysfunction in PD. PINK1
contains a putative catalytic serine–threonine kinase...
Tài liệu PARKINSON’S DISEASE pptx
... rolling over in
bed, and turning around and changing direction while
walking.
Swallowing and Drooling
Swallowing is something we do without thinking, and
when that reflex slows down in Parkinson’s ... advanced
Parkinson’s symptoms themselves.
Problems of Daily Living
In advanced Parkinson’s disease, the routine activities
of dressing, hygiene, and feeding become increasi...
Tài liệu THERAPEUTICS of PARKINSON’S DISEASE and OTHER MOVEMENT DISORDERS docx
... 995.
88 PARKINSON’S DISEASE AND PARKINSONISM
Parashos, S.A., Wielinski, C.L. and Kern, J.A. (2004) Frequency,
reasons, and risk factors of entacapone discontinuation in
Parkinson’s disease. Clinical ... botulinum toxin B for sialorrhea in
Parkinson’s disease. Neurology, 62,37 40.
Paci, C., Thomas, A. and Onofrj, M. (2001) Amantadine for
dyskinesia in patients affected...
Tài liệu Parkinson’s Disease and Related Disorders docx
... al., 2005). In polyglutamine disease, the
disease proteins together with their interaction
partners such as CREB – binding protein and
ubiquitin-binding-domains are sequestered
into the inclusion ... suggest
that neuromelanin in the Parkinson’s disease
brain differs to that in the normal brain. The
interaction of neuromelanin with iron has been
shown to differ in the parkinso...
Tài liệu Báo cáo khoa học: Proteomic analysis of dopamine and a-synuclein interplay in a cellular model of Parkinson’s disease pathogenesis docx
... dopamine treatment, overexpres-
sion of a-synuclein significantly affected the levels of
four proteins [stathmin 1, glutathione S-transferase
(GST)p, Ran 1 binding protein and C1q binding pro-
tein], ... proteins were
included in two different networks and proteins
responding to dopamine treatment only segregated
from those showing a response to a-synuclein overex-
pression alone or in...
Từ khóa:
- scientific and clinical research in alzheimer s disease
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- therapeutic applications of induced pluripotent stem cells in parkinson s disease