synaptic dysfunction in parkinson´s disease
Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Autosomal-recessive genes in Parkinson’s disease – a common pathway? docx
Ngày tải lên :
18/02/2014, 14:20
... Parkin, PINK1, DJ-1 and HtrA2 activity remains to be determined Parkin can be phosphorylated by a number of kinases including casein kinase 1, protein kinase A, protein kinase C [86] and cyclin-dependant ... inactivation of Drosophila PINK1 using RNAi suggested that PINK1 maintains neuronal survival by protecting neurons against oxidative stress [79] In mammalian cell culture, PINK1 protects against ... cytoplasmic pool of PINK1 has been described [16,17] PINK1 is of great interest to research into mitochondrial dysfunction in PD PINK1 Autosomal recessive genes in Parkinson’s disease contains a putative...
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Báo cáo khoa học: LRRK2 in Parkinson’s disease: function in cells and neurodegeneration doc
Ngày tải lên :
23/03/2014, 04:20
... protein Similar to b-RAF, LRRK2 encodes a kinase domain with serine ⁄ threonine activity [7], but in concert with a number of conserved domains, including a GTPase domain Multidomain proteins ... functional kinase domains often utilize intrinsic protein kinase activity distinct from the canonical protein kinase ⁄ substrate interaction For the same reason that the exis- Function in cells ... receptor-associated kinase family Many of these kinases have clear roles in the MAPK pathway, and MLK proteins serve as critical mitogen-activated protein kinase kinase kinase (MAPKKK) proteins in signaling cell...
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Báo cáo khoa học: LRRK2 in Parkinson’s disease: in vivo models and approaches for understanding pathogenic roles pdf
Ngày tải lên :
23/03/2014, 04:20
... moesin, a protein that anchors the actin cytoskeleton to the plasma membrane [24] Although cytoskeleton proteins are known as frequent ‘contaminants’ in the process of searching binding proteins, ... domain of Pats1 interacted with myosin heavy chain, whereas the deletion of Pats1 caused an alteration in the localization of myosin heavy chain [17] Moreover, over-expression of the kinase domain ... ROCO proteins in D discoideum indicate their roles in regulating cytoskeleton structures Interestingly, it was previously noted that human LRRK2 binds to cytoskeleton-related proteins [22], microtubules...
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Báo cáo khoa học: LRRK2 in Parkinson’s disease: genetic and clinical studies from patients ppt
Ngày tải lên :
23/03/2014, 04:20
... protein comprising (from N-terminal to C-terminal), armadillo (ARM), ankryn (ANK), LRR, Ras of complex proteins (ROC), C-terminal of ROC (COR), mitogen-activated protein kinase kinase kinase ... Alzheimer’s disease [42] The LRRK2 G2385R is located in the WD40 domain, and the base substitution alters the net positive charge of the WD40 domain Because WD40 domain is involved in mediating protein–protein ... Paisan-Ruiz C, Martinez-Gil A, Ruiz-Martinez J, Saenz A, Singleton AB, Lopez de Munain A & Perez-Tur J (2006) Parkinson’s disease due to the R1441G mutation in Dardarin: a founder effect in the Basques...
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Psychiatric and Cognitive Disorders in Parkinson’s Disease pptx
Ngày tải lên :
28/03/2014, 22:21
... Parkinson’s disease Parkinsonism and Parkinson’s disease 34 Cognitive deficits in Parkinson’s disease 55 Depression in Parkinson’s disease 88 Anxiety, phobias, apathy, and premorbid personality in ... 1817 Introduction Since its initial description in 1817, PD remains an unsolved clinical problem, with a changing focus during the past four decades Thus, the 1960s were the years of dopamine ... receiving complex l-dopa dosing schedules Dyskinesias Dyskinesias are involuntary choreic, ballistic, or dystonic movements elicited by l-dopa or dopamine agonists Dyskinesias occurring during...
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báo cáo hóa học:" Retinal pigment epithelial cells secrete neurotrophic factors and synthesize dopamine: possible contribution to therapeutic effects of RPE cell transplantation in Parkinson''''s disease" doc
Ngày tải lên :
18/06/2014, 15:20
... brain injection on a stereotaxic frame (Myneurolab, USA) 6-OHDA (6 μg in μl) was dissolved in normal saline containing ascorbic acid (0.2 mg/ml), and injected into the right medial forebrain ... peroxidase-coupled avidin-biotin staining kit (ABC kit, Vector Laboratories, UK) were used For HE staining, the tissue sections were submerged into the hematoxylin solution (0.5% hematoxylin, 5% aluminium ammonium ... containing transplants and mounted to gelatin coated slides Adjacent sections were processed for hematoxylin-eosin (HE) stain and immunohistochemistry The sections were stained against cytokeratin...
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Báo cáo hóa học: " Reduction of freezing of gait in Parkinson’s disease by repetitive robot-assisted treadmill training: a pilot study" doc
Ngày tải lên :
19/06/2014, 08:20
... Changes in Motor Outcomes Following Robot-Assisted Gait Training Participant Participant Participant Participant Median % Change Baseline Endpoint Baseline Endpoint Baseline Endpoint Baseline Endpoint ... Motor blocks in Parkinson’s disease Neurology 1992, 42(2):333-339 Hong M, Earhart GM: Rotating treadmill training reduces freezing in Parkinson disease: preliminary observations Parkinsonism Relat ... freezing in Parkinson’s disease and the stride length sequence effect interaction Brain 2009, 132(Pt 8):2151-2160 Iansek R, Huxham F, McGinley J: The sequence effect and gait festination in Parkinson...
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báo cáo hóa học: "Effect of gait speed on gait rhythmicity in Parkinson''''s disease: variability of stride time and swing time respond differently" docx
Ngày tải lên :
19/06/2014, 10:20
... dynamics in Parkinson's disease Movement Disorders 2004, 19:S139-S139 Thaut MH, McIntosh GC, Rice RR, Miller RA, Rathbun J, Brault JM: Rhythmic auditory stimulation in gait training for Parkinson's disease ... Parkinson's disease J Neurol Neurosurg Psychiatry 2001, 70:289-297 Vieregge P, Stolze H, Klein C, Heberlein I: Gait quantitation in Parkinson's disease locomotor disability and correlation to clinical ... changes is impaired in PD, i.e., stride variability is increased in PD [11,14-20] The mechanisms underlying the increased stride variability in PD have not been widely investigated The increased stride...
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báo cáo hóa học: "Effect of step-synchronized vibration stimulation of soles on gait in Parkinson''''s disease: a pilot study" doc
Ngày tải lên :
19/06/2014, 10:20
... encouragement or instructions might affect their walking speed The mean walking distance increased by 9.4% in the PD group and by 5.2% in the control group during the S-VS walking The 6-minute walking test ... soles disease subject obtained vibratory a 45-year-old without Strideand with (right) theduring 6-minute walking Parkinson's Stride intervals of the left leg from a 45-year-old Parkinson's disease ... right legs in the stride interval and its corresponding CV Parkinson's disease group Figure shows an example of the stride intervals measured during walking with and without the S-VS in a PD subject...
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báo cáo hóa học: " Effect of optical flow versus attentional strategy on gait in Parkinson''''s Disease: a study with a portable optical stimulating device" pptx
Ngày tải lên :
19/06/2014, 10:20
... potentials in normal and Parkinson's disease subjects Brain 1995, 118:913-933 Glickstein M, Stein J: Paradoxical movement in Parkinson's disease Trends Neurosci 1991, 14:480-482 Majsak MJ, Kaminski ... dopaminergic function), in our study, are influenced by optic flow, showing a nearly significant increase of stride length Finally, regarding the pathophysiological model of altered gait in PD, in ... locomotion in Parkinson's disease Brain 1999, 122(Pt 1):111-120 Dietz MA, Goetz CG, Stebbins GT: Evaluation of a modified inverted walking stick as a treatment for parkinsonian freezing episodes...
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báo cáo hóa học: " Psychometric validation of the revised SCOPADiary Card: expanding the measurement of nonmotor symptoms in parkinson’s disease" potx
Ngày tải lên :
20/06/2014, 15:20
... functioning, but not necessarily involve mobility The items in factor - difficulty concentrating or remembering and feelings of anxiety or panic - are distinct from the remaining items in that ... items (feelings of exhaustion or fatigue, difficulty concentrating or remembering, feelings of anxiety or panic, unexplained pains, difficulty swallowing, frequent or urgent urination, sweating too ... tapped into issues of mobility (walking and changing position), the second factor (Physical Functioning) included items that covered a broader range of symptoms, including impairment in fine motor...
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MECHANISMS IN PARKINSON’S DISEASE – MODELS AND TREATMENTS pot
Ngày tải lên :
27/06/2014, 13:20
... dressing, feeding, bathing, getting out of chairs, and turning in bed Constipation, chewing and swallowing difficulties, drooling of saliva, and urge incontinence of urine are common complaints ... Parkinsons disease drugs; increase water and salt intake; fludrocortisone, ephedrine, or midodrine Drooling 0-5% atropine eye drops sublingually, scopoderm patch, or botulinum toxin injections into ... after a line or two (Lee et al, 2009) Complaints within the first years of the disease of falls (especially backwards), fainting, urinary incontinence, prominent speech, disturbed swallowing, amnesia,...
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Báo cáo y học: "Phenomenology and management of cognitive and behavioral disorders in Parkinson''''s disease. Rise and logic of dementia in Parkinson''''s disease" pptx
Ngày tải lên :
08/08/2014, 21:20
... situations, including the processing of relevant information, problem solving, and planning ability Several tasks examining this require cognitive flexibility or internally guided behavior: Wisconsin ... The place of dementia in Parkinson's disease: A methodologic saga Advances in Neurology 1999, 80:403-408 Cummings JL: Intellectual impairment in Parkinson's disease: Clinical, pathologic, and ... Karenberg A: Hallucinations in Parkinson disease in the prelevodopa era Neurology 2006, 66:93-98 Brown RG, Marsden CD: How common is dementia in Parkinson's disease? Lancet 1984, 2:1262-5 Mindham RHS:...
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báo cáo khoa học: " Copy number variation in Parkinson’s disease" docx
Ngày tải lên :
11/08/2014, 12:20
... mutations in the SNCA gene, encoding the αsynuclein protein, in dominantly inherited disease [6] This was the first evidence that genomic variation could result in an inherited form of PD The subsequent ... promoter and at intron fragments (red) Pathogenic copy number variation in autosomal dominant Parkinson’s disease A seminal discovery in the study of PD was the report of missense mutations in the SNCA ... identified, indicating a reduced penetrance of disease [7] Segmental intra-allelic duplication and interallelic recombination with unequal crossing-over Toft and Ross Genome Medicine 2010, 2:62...
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báo cáo hóa học: " CD200-CD200R dysfunction exacerbates microglial activation and dopaminergic neurodegeneration in a rat model of Parkinson’s disease" pot
Ngày tải lên :
19/06/2014, 22:20
... CD200R in MDMs induced by various stimuli is impaired in the older groups, especially in PD patients, implying an intrinsic abnormality of CD200-CD200R signalling in PD brain Interestingly, CD200R ... nigral dopaminergic cell death induced by 6hydroxydopamine through inhibition of both mixed-lineage kinase 3/cJun NH2-terminal kinase (JNK3) and apoptosis-inducing kinase 1/JNK3 signaling pathways ... following brain injury: participation of interleukin-1 beta J Neurotrauma 1996, 13:801-808 79 Ghirnikar RS, Lee YL, Eng LF: Inflammation in traumatic brain injury: role of cytokines and chemokines...
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Tài liệu Báo cáo khoa học: Proteomic analysis of dopamine and a-synuclein interplay in a cellular model of Parkinson’s disease pathogenesis docx
Ngày tải lên :
15/02/2014, 01:20
... proteins were included in two different networks and proteins responding to dopamine treatment only segregated from those showing a response to a-synuclein overexpression alone or in combination ... Parathymosin eIF5A isoform B L7 ⁄ L12, mitochondrial Peroxiredoxin Annexin A5 Annexin A2 Aldolase A Fascin Pyruvate kinase VDAC-2 Stathmin Ran1BP GSTp C1qBP Profilin Enolase RuvB-like CRMP4 Lamin A ... obtained from ppi spider starting from the proteins grouped as above (Tables S2 and S3) In both cases, bioinformatic analysis revealed that the NF-jB pathway could be involved in determining...
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Tài liệu Báo cáo khoa học: Emerging pathways in genetic Parkinson’s disease: Potential role of ceramide metabolism in Lewy body disease pptx
Ngày tải lên :
18/02/2014, 14:20
... phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase Biochemistry 46, 10170– ... have a key role in our understanding of the mechanisms of the disease We propose that pathology data will, in most cases, be more insightful than clinical data in defining the disease This is ... Transferase activity ATPase Dopamine transmission and synaptic vesicle dynamics Protein kinase Gaucher’s disease ⁄ Parkinson’s disease in heterozygotes Neurodegeneration with brain iron accumulation type...
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Báo cáo khoa học: High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract Implications for Parkinson’s disease docx
Ngày tải lên :
16/03/2014, 11:20
... as salsolinol [23] In line with the suggested role of ADHs and ALDHs in protection against toxic insults, mRNAs encoding these enzymes have previously been identified in tissues forming a physiological ... levels in all tissues in both mice and rats This is in line with the different substrate repertoire known for this enzyme Rather than being involved in ethanol and retinol oxidation, Adh3 is mainly ... studies with antisera to substance P, vasoactive intestinal polypeptide, enkephalins, somatostatin, gastrin ⁄ cholecystokinin, neurotensin and dopamine beta-hydroxylase Neuroscience 5, 689–744 FEBS...
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PARKINSON’S DISEASE: National clinical guideline for diagnosis and management in primary and secondary care ppt
Ngày tải lên :
31/03/2014, 13:20
... binding ratio alone52 123I-FP-CIT SPECT: Binding index in putamen contralateral to initially clinically affected side50 TRODAT-1 SPECT: Binding index in putamen contralateral to initially clinically ... monitoring and medication adjustment • clinical monitoring and medication adjustment • a continuing point of contact for support, including home visits, when appropriate • a continuing point of ... required in tailoring individual therapy and in timing treatment initiation It is hoped that this guideline on Parkinson’s disease will be of considerable help to those involved at all levels in these...
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Báo cáo hóa học: " Audio-Biofeedback training for posture and balance in Patients with Parkinson’s disease" doc
Ngày tải lên :
19/06/2014, 08:20
... baseline (within one week before the beginning of the intervention), immediately post training (within one week after the last training session) and four weeks after the completion of the training ... target zones (defined by a pattern of trunk inclination and local accelerations) which were adaptively estimated during a short initial calibration phase in the beginning of each training session ... several training sessions (up to training sessions) in their home to explore the possibility for future independent home training with the ABF system The home sessions were performed in the last...
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