Báo cáo khoa học: Binding of activated Factor XII to endothe

Báo cáo khoa học: Binding of activated Factor XII to endothelial cells affects its inactivation by the C1-esterase inhibitor pptx

... Binding of activated Factor XII to endothelial cells affects its inactivation by the C1-esterase inhibitor Inger Schousboe Department of Medical Biochemistry & Genetics, The Panum ... its major endogenous inhibitor. Hence, the function of FXII may be localized at cellular surfaces. Keywords: C1-esterase inhibitor; endothelial cells; Factor...

Ngày tải lên : 23/03/2014, 20:22

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Tài liệu Báo cáo khoa học: Phosphorylation of cyclin dependent kinase 4 on tyrosine 17 is mediated by Src family kinases pptx

... transfected into HCT116 cells, and treatment of cells with Src family kinase inhibitors blocked the tyrosine 17 phosphorylation of cyclin dependent kinase 4. Taken together, the results obtained in the present ... strategies for the treatment of cancer. The activity of the CDK4 ⁄ cyclin D holoenzyme is regulated by multiple mechanisms, the most important of which...

Ngày tải lên : 18/02/2014, 18:20

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Báo cáo khoa học: Binding of cGMP to the transducin-activated cGMP phosphodiesterase, PDE6, initiates a large conformational change involved in its deactivation ppt

... 20–30% by binding of the Pab ⁄ Pc complex existing in the soluble fraction [13]. Therefore, binding of the Pab ⁄ Pc complex to membranes and the resulting expression of a [ 3 H]cGMP -binding ... in Pabc. Together with the result showing that Pc inhibits cGMP -binding to Pabc (Fig. 6), these results imply that the scheme by which cGMP binds to P abc ﬁrst and...

Ngày tải lên : 06/03/2014, 00:21

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Tài liệu Báo cáo khoa học: Binding of N- and C-terminal anti-prion protein antibodies generates distinct phenotypes of cellular prion proteins (PrPC) obtained from human, sheep, cattle and mouse doc

... [18]. Taken together, the results of various signal intensities of the three PrP C bands are accredited to the development of the truncated isoforms, to the epitope recognition of the antibodies ... corresponding to the N-terminally truncated form. The distribution of the signal intensities of the Fig. 1. Sequence alignment of prion proteins of huma...

Ngày tải lên : 19/02/2014, 02:20

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Tài liệu Báo cáo khoa học: Role of transcription factor activator protein 1 (AP1) in epidermal growth factor-mediated protection against apoptosis induced by a DNA-damaging agent doc

... that growth factors such as nerve growth factor, insulin-like growth factor, ﬁbroblast growth factor, epidermal growth factor (EGF), and hepatocyte growth factor can suppress apoptosis of target ... transcription factor, thereby inhibiting them, the PtdIns3- K ⁄ Akt signaling pathway has emerged as the major mechanism by which growth factors promote cell sur- vival [26]. T...

Ngày tải lên : 19/02/2014, 06:20

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Tài liệu Báo cáo khoa học: Binding of ligands originates small perturbations on the microscopic thermodynamic properties of a multicentre redox protein pptx

... at a ratio of 100 : 8 of cytochrome vs. mediator to avoid interference caused by speciﬁc binding of mediators to the protein. For the redox titrations per- formed at pH 8.1 the mediators gallocyanine ... of partner binding on the thermodynamic properties of the haems of cytochrome c 3 . Because the rubredoxin is a very acidic protein and binds to the cyto...

Ngày tải lên : 19/02/2014, 17:20

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Báo cáo khoa học: Binding of ATP at the active site of human pancreatic glucokinase – nucleotide-induced conformational changes with possible implications for its kinetic cooperativity doc

... equilibrium binding of Glc to the ligand-free WT hGK and its binary AdN complexes was determined by its enhancement of the ITF signal (Table 2). In the absence of AdNs, a hyperbolic binding isotherm ... ( 15°). These deﬁning residues were previously used to monitor the opening of the cleft Table 2. The effect of ATP analogues on the equilibrium binding...

Ngày tải lên : 06/03/2014, 00:20

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Báo cáo khoa học: Inhibition of an iron-responsive element/iron regulatory protein-1 complex by ATP binding and hydrolysis docx

... show whether ATP inhibits the binding of IRP-1 to IRE, or instead facilitates dissociation of the complex. Enhancement of ATP hydrolysis by IRE in the presence of IRP-1, but absence of hydrolysis ... hydrolysis of [ 32 P]ATP[cP] in the presence of 0–400 ng of IRE (Fig. 8). Compared to the amount of ATP hydrolyzed with 400 ng of IRP alone, addition of...

Ngày tải lên : 07/03/2014, 09:20

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Báo cáo khoa học: Binding of the volatile general anesthetics halothane and isoﬂurane to a mammalian b-barrel protein doc

... (http://www.microcal.com/). This software provides the best-ﬁt values for the heat of binding (DH°), the stoichiometry of binding (n), and the association constant (K a ) from plots of the heat evolved per mol of anesthetic ... For both anesthetics, the free energy of binding (D G °) exceeded the heat of binding (DH°) by more than a factor of two (Table...

Ngày tải lên : 07/03/2014, 16:20

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Báo cáo khoa học: Interactions of elongation factor EF-P with the Escherichia coli ribosome doc

... determined, as was the area of each peak. The ratio of the density, which is related to the amount of EF-P bound, to the area of the peaks, which is related to the total amount of the ribosome population ... decoding of the mRNA transcript. For example, by binding to the A-site, EF-P may prevent the incorrect position- ing of the fMet-RNA in...

Ngày tải lên : 16/03/2014, 06:20

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