Báo cáo khoa học: Expression profiling reveals differences in metabolic gene expression between exercise-induced cardiac effects and maladaptive cardiac hypertrophy pot

... to occur in maladaptive hypertrophy, we found striking differences in expression of genes involved in metabo- lism between adaptive and maladaptive hypertrophy. Experimental procedures Animal handling ... et al. Gene expression in exercise-induced cardiac hypertrophy FEBS Journal 272 (2005) 2684–2695 ª 2005 FEBS 2689 signalling proteins between adaptive and...

Ngày tải lên: 23/03/2014, 13:20

... regulate the expression of downstream genes involved in auxin signaling. The differential and overlapping expression patterns of individual members of these gene families in rice offer an amazingly ... found crosstalk between auxin and other plant hormones [21–24]. Our study also shows that genes involved in cytokinin (e.g. cytokinin-O- glucosyltransferase, cytokinin dehydro...

Ngày tải lên: 07/03/2014, 01:20

... protein) were incubated for 3 min with or without 5 lm CdCl 2 or 5 lm CuCl 2 in the assay medium containing 110 mm KCl, 20 mm Tris, 5 mm KH 2 PO 4 ,50mm creatine, an excess of creatine kinase and ... an increase in passive membrane permeability to cations and anions, uncoupling and swelling, and inhibition of respiration in state 3 [3,4]. Furthermore, it has been suggested that...

Ngày tải lên: 16/03/2014, 02:20

... involved in glucose homeostasis by binding to the proglucagon gene G2 promoter element, and downregulation of an NADH-ubiquinone oxidore- ductase member gene (CI-B9) and the pyruvate kinase gene ... reticulum protein that blocks the processing of sterol regulatory element-binding proteins (SREBPs) by binding to SREBP cleavage-activating protein, thus preventing the latter from esc...

Ngày tải lên: 16/03/2014, 04:20

... B 1 ,C 2 ,Y 1 and Y 2 indicate the sequence Neu5Ac–Hex–Hex. The ring fragments 0,2 A 3 and 0,2 A 3 -18 in combination with lack of the 0,3 A 3 ring fragment ion are typical of a 1–4-linkage between ... described here are terminated with galactose and ⁄ or sialic acid resi- dues, which can be explained by the defect of cathep- sin A in galactosialidosis patients, resulting in ins...

Ngày tải lên: 29/03/2014, 09:20

... cycle of user input and sys- tem response, beginning when a user submits a piece of writing to be reviewed by the system. The system determines the grammatical errors in the writing, and responds ... formation adverb placement incorrect preposition missing "to be" verb missing object of verb missing preposition missing auxiliary missing determiner missing subject extra auxilia...

Ngày tải lên: 17/03/2014, 07:20

... remains poor, and only the RTCS gene encoding a LOB domain protein was suggested to be a potential regulator of the maize crown and brace root initiation [13–15]. Recently, sev- eral genes involved ... metabolism (19.6%), sig- naling pathway (12.8%) and cellular transport (12.6%). Gene categories showed an obvious increase in tran- script abundance involved in protein binding a...

Ngày tải lên: 22/03/2014, 17:20

... role in sensing nutrient levels and modulating metabolism accordingly [16] and could be linked to changes in expression of metabolic genes, by their in uence as transcriptional activators. Investigations ... regulated independently by the main fuel sources in muscle and by insulin through directly altering the expression of the human PDK2 and PDK4 isoforms. In addition...

Ngày tải lên: 07/03/2014, 17:20

... production of the pro -in ammatory cytokines interleukin- 1b, interleukin-18 and interleukin-33. The molecular mechanisms involved in TNF-a-induced caspase-1 gene expression remain poorly defined, ... interleukin-1b, interleukin-18 and interleukin-33 [6–9]. Involvement of caspase-1 in TNF-a-induced cytotoxicity has been determined by employing inhibitors of caspase-1 [10–12]. Caspa...

Ngày tải lên: 16/03/2014, 05:20

... (B), the side-chains of residues 29, T34 and E131 are shown. The hydrogen bonds between N29 and Oc and T34 and Oc, and between N29 and Nd and E131 and Oe2, in the wild-type protein are shown as ... the side-chains of Y24, residue 39, F41 and Q149 are shown. The hydrogen bonds between D39 and Od1 and Q149 and Ne, and between D39 and Od2 and Q149 and Ne...

Ngày tải lên: 18/02/2014, 13:20