Báo cáo khóa học: Sequence selective binding of bis-daunorubicin WP631 to DNA doc

... binding of bis-daunorubicin WP631 to DNA Keith R. Fox 1 , Richard Webster 1 , Robin J. Phelps 1 , Izabela Fokt 2 and Waldemar Priebe 2 1 School of Biological Sciences, University of Southampton, ... revealed up to six distinct binding modes to herring sperm DNA. T h e tightest of thes e corresponded to the i nteraction of one drug molecule with six base p airs wit...

Ngày tải lên: 23/03/2014, 12:20

... Ser46. Analysis of phosphomimetic mutations on hsMOK2 capacity to bind DNA Binding of hsMOK2 to DNA may be affected, either positively or negatively, by phosphorylation. There- fore, to determine ... software (Bio-Rad). Results were expressed as a percentage of binding to JSAP1 (21–101) domain (mean ± SD of three different experiments). M. Harper et al. Phosphorylation...

Ngày tải lên: 07/03/2014, 01:20

... Evaluation Method of Words Tendency using Decision Tree El-Sayed Atlam, Masaki Oono, and Jun-ichi Aoe Department of Information Science and Intelligent Systems University of Tokushima Tokushima,770-8506, ... attributes to measure frequency change of word quantitatively, these four attributes were extracted automatically from electronic texts. According to the comparison bet...

Ngày tải lên: 20/02/2014, 16:20

... exist to the set of constraint equations, each varl in the set of equations must have a solution. For exam- ple, if 5 instances of sofas are known for varsola, but every assignment of a value to ... the number of possible solutions given all the possible assignments of values to these variables. The variables of interest for our corpus are the ob- jects of type t...

Ngày tải lên: 20/02/2014, 18:20

... nature of the sample. Located in the intersection of these two backgrounds, the aim of the present study is twofold, i.e. (1) to introduce a quantitative framework in which the dynamic nature of ... numbers of hapax legomena and of dislegomena are increasing (see Figure 1 for hapax). A convenient test to see if the sample is lo- cated in the LNRE zone is to see the r...

Ngày tải lên: 20/02/2014, 18:20

... type of natural language processing program that must be able to handle very large amounts of text necessitates dictionaries of substantial size, of the order of at least tens of thousands of ... and has to do with the complexity of the task of creating a lexical entry. It can roughly be viewed as a measure of the time it takes to create a new lexical entry,...

Ngày tải lên: 22/02/2014, 09:20

... mg of [2- 13 C 1 ]- or [3- 13 C 1 ]glucose, 3.5 mg of phosphoenol pyruvate, 0.5 mg of ATP, 6 mg of 2-oxoglutaric acid, 0.6 mg of NAD + , 2.5 mg of NH 4 Cl, 5mgofa 13 C-isotopologue mixture of ... transfor- mation of these isotopologue libraries into random libraries of 13 C isotopologues of FMN and their utili- zation for NMR studies of the plant blue light recep- tor, p...

Ngày tải lên: 07/03/2014, 05:20

... habituation of the secretory r esponse. In this paper, we use amperometric detection to monitor the habituation of PC12 cells to mul- tiple s timulations of ATP or its agonist. Cells habituate to 30 ... Changing [Mg 2+ ]from0. 0to1 .2m M Mg 2+ halved the initial secretory response of PC12 cells to 30 l M ATP, while an increase to 3.0 m M Mg 2+ reduced the initial secretory r...

Ngày tải lên: 07/03/2014, 16:20

... [29,29a]. Needless to say, a structure- based rationale is obligatory to comprehend the causa- tive factors for the destabilization of PNA DNA in the presence of mismatch compared to DNA duplex. Inci- dentally, ... TC(7–8) step of PD mut (Fig. 2F) of the DNA strand show significant differences. This is due to con- siderable movement of cytosine (C7) of the A24 C7 misma...

Ngày tải lên: 07/03/2014, 21:20

... the input to the acquisition of attributes, which consists of four stages: 1) identification of a noisy pool of candidate at- tributes, as remainders of queries that also con- tain one of the class ... construction of a reference internal vector representation for a small set of seed attributes provided as input. A reference vector is the nor- malized sum of the individual...

Ngày tải lên: 08/03/2014, 21:20