Báo cáo khoa học: Ixocarpalactone A isolated from the Mexican tomatillo shows potent antiproliferative and apoptotic activity in colon cancer cells pot

... Journal 273 (2006) 5714–5723 ª 2006 The Authors Journal compilation ª 2006 FEBS 5723 Ixocarpalactone A isolated from the Mexican tomatillo shows potent antiproliferative and apoptotic activity in ... cancer cells. To investigate the effects of IxoA on apoptosis, we used acridine orange ⁄ ethidium bromide staining and DAPI staining and found a marked i...

Ngày tải lên: 23/03/2014, 10:20

... O 2 affinity. The reaction of nitrite with fully oxygenated carp Hb at 100% So 2 was clearly autocatalytic. The reac- tion rate initially showed a sharp increase, reached a marked peak and then displayed a ... stabilization by ATP and the effects of changes in O 2 tension ⁄ saturation during the reaction. The data revealed that the reactivity is dynamically in uenced b...

Ngày tải lên: 16/03/2014, 06:20

... s tempting to speculate that interactions between monomeric G-actin and actin-binding proteins are a potential target of regulation by RhoA GTPase. Furthermore, our data indicated that RhoA-mediated CTGF/CCN2 ... utilized jas- plakinolide, a compound that induces actin polymeriza- tion by increasing actin nucleation and stabilizing actin filaments and swinholide A, a drug that seq...

Ngày tải lên: 19/02/2014, 16:20

... rectal carcinoma as compared to normal colonic tissue. Colon carcinoma cells, rectal carcinoma cells and their normal healthy tissue counterparts were harvested ( 1a, carcinoma cells; 4a, normal ... protein kinase 1 (DAPK-1) is a Ca 2+ ⁄ calmodulin-regulated serine ⁄ threonine kinase composed of multiple functional domains, including a kinase domain, a calmodulin-binding domain,...

Ngày tải lên: 18/02/2014, 17:20

... and assume that learning takes place in an environment where simple semantic representations of the speech intent are available to the acquisition mechanism. For example, we approximate the ... the greater problem as that of learning from inputs like Phon. Input: /~raebltslne~ b~W t/ Sem. Input: { BOAT A IN RABBIT THE BE } (The rabbit's in a boat.) w...

Ngày tải lên: 08/03/2014, 07:20

... the A super- family, containing a- conotoxins, aA-conotoxins and jA-conotoxins [1]. Competitive antagonists of the nicotinic acetylcholine receptors (nAChRs) belong to the a and aA families. On the ... r-conotoxins and aS-conotoxins; the T superfamily, containing e-conotoxins and v-conotoxins; the P superfamily, containing the spasmodic peptides; the I superfamily...

Ngày tải lên: 16/03/2014, 11:20

... second hairpin loop and the papain region including Trp177. In addition, in the papain– AtCYS1 complex the inhibitor Arg12 residue faces papain Lys156, resulting in an unfavourable electrostatic inter- action ... amplification of the AtCYS1 cDNA using specific primers carrying a BamHI site (forward: GGATCCGCGGATCAACAAG CAGGAACA) and a SalI site (reverse: GTCGACTCA CGTGGTCT...

Ngày tải lên: 17/03/2014, 03:20

... facet. Finally, we train a machine learning classi- fier on training data and use it to classify unseen test examples, assigning a Table 1 label for each reference answer facet. We used a variety ... be at a level that fa- cilitates detailed assessment of the learner’s under- standing, indicating exactly where and in what manner the answer did not meet expectations and...

Ngày tải lên: 23/03/2014, 17:20

... and elongations of the fatty acyl chain to generate EPA and DHA from a- linolenic acid (18:3 D9,12,15 ). Besides the main routes leading to DHA via D 6 -desatu- ration, some algae display an alternate ... oils and fatty acids, in particular the use of algal oils containing long chain polyunsaturated fatty acids (LCPUFAs). The most prominent of these are the health benefici...

Ngày tải lên: 20/02/2014, 01:20

... be reached, and the BApNA was then added. The residual trypsin activity was measured at 410 nm with a U-2800 spectrophotometer (Hitachi, Tokyo, Japan). The assay for chymotrypsin inhibitory activity ... (GeneBank accession number AY713305) by using 3¢-RACE and 5¢-RACE (Fig. 1). The 591 bp full-length cDNA includes a 3¢-UTR and two polyA signals (AATAAA) located upstream...

Ngày tải lên: 15/03/2014, 09:20