Báo cáo khoa học: The regulation of the endosomal compartment by p53 the tumor suppressor gene docx
Báo cáo khoa học: Versatile regulation of multisite protein phosphorylation by the order of phosphate processing and protein–protein interactions pptx
... in the previous sections for the special case of weak binding of the enzymes, holds more generally. Individual regulation of the phosphorylation sites So far, we have focused our analysis on the ... finely tuned by a single kinase. Taken together, this study suggests a versatile regulation of protein activation by the combined effect of structural, kinetic and the...
Ngày tải lên: 07/03/2014, 10:20
Báo cáo khoa học: Light regulation of CaS, a novel phosphoprotein in the thylakoid membrane of Arabidopsis thaliana doc
... 1A and 4B) and the stn7 mutant (Fig. 4B). The involvement of STN8 in the phosphorylation of CaS was further investigated by isolation of phospho- peptides from the wild-type and the stn7 and stn8 thylakoids, ... obtain further insights into the mechanisms responsible for the observed phenotype, we analyzed the photochemical efficiency of PSII by fluorescence measurem...
Ngày tải lên: 30/03/2014, 04:20
Tài liệu Báo cáo khoa học: Redox regulation of dimerization of the receptor proteintyrosine phosphatases RPTPa, LAR, RPTPl and CD45 pdf
... conditions. The ectodo- mains of both monomers in the dimer are required for this effect, suggesting that the epitope tag of one monomer is masked by the ectodomain of the other monomer in the dimer, ... and suggest an important role for the catalytic cysteine of D2 in the process. Discussion Whether regulation of RPTPs by dimerization is a general feature is a...
Ngày tải lên: 18/02/2014, 17:20
Tài liệu Báo cáo khoa học: Down-regulation of heme oxygenase-2 is associated with the increased expression of heme oxygenase-1 in human cell lines docx
... The intracellular concentration of heme is maintained by the rate of its synthesis and degrada- tion [1]. Many enzymes and their regulators are responsible for heme synthesis [1,2]. On the other hand, ... similar to that evoked by cadmium [36] or sodium nitroprusside [38], each of which activated the expression of a reporter gene under the regulation of the 4.5-k...
Ngày tải lên: 19/02/2014, 05:20
Báo cáo khoa học: Transcriptional regulation of the desferrioxamine gene cluster of Streptomyces coelicolor is mediated by binding of DmdR1 to an iron box in the promoter of the desA gene doc
... control of the expression of the des cluster is mediated by the DmdR1 regulator. Results Deletion of the desA gene of S. coelicolor blocks desferrioxamine biosynthesis The organization of the putative ... interesting that the )10 sequence is located inside the iron box of desA (nucleotides 7–12 of the iron box), explaining the regulation of desA expre...
Ngày tải lên: 16/03/2014, 11:20
Báo cáo khoa học: Mechanical regulation of the Cyr61/CCN1 and CTGF/CCN2 proteins Implications in mechanical stress-associated pathologies pptx
... or generated by the cells results in profound alterations of the histo- morphometry, phenotype and function of the cells [3–7]. The onset of this process is characterized by the activation of ... induce up -regulation in the expression of the Cyr61 gene [71]. In line with these results it was shown in NIH 3T3 fibroblasts that the Cyr61 gene belongs to a group...
Ngày tải lên: 30/03/2014, 10:20
Tài liệu Báo cáo khoa học: Solution structure of hirsutellin A – new insights into the active site and interacting interfaces of ribotoxins docx
... mecha- nism of transphosphorylation, which implies the A B Fig. 3. Stereo diagram of the active center of HtA. (A) Superposition of the active-site residues of the 20 conformers of the solu- tion ... superposition of the active site of RNase T1, a-sarcin and HtA is shown in Fig. 3B. It is known that other side chains in the vicin- ity of these amino acids are a...
Ngày tải lên: 18/02/2014, 08:20
Tài liệu Báo cáo khoa học: Abstract Integration of Metabolism and Survival PP-1 The metabolic switch in liver methionine metabolism pptx
... activity of APE1 and the thermal stability of DNA duplexes. The efficiency of the removal and the thermal stability of DNA duplexes varied depending on the reaction conditions and the nature of the ... adduct of a molecular mass of around 100-kDa. Unexpectedly, the forma- tion of the 100-kDa adduct does not require the incorporation of the photoreactive...
Ngày tải lên: 19/02/2014, 07:20
Tài liệu Báo cáo khoa học: Structural characterization of Ca2+/CaM in complex with the phosphorylase kinase PhK5 peptide pdf
... subunit and the d subunit is an intrinsic mole- cule of CaM that binds to the enzyme even in the absence of Ca 2+ [2]. The regulation of PhK through Ca 2+ ⁄ CaM enables the coordination of muscle ... structural alignment of these three models shows that they are indeed close structural Table 2. The quality of fits (described by the chi-squared per degrees of fre...
Ngày tải lên: 19/02/2014, 17:20
Tài liệu Báo cáo khoa học: NMR structure of AII in solution compared with the X-ray structure of AII bound to the mAb Fab131 pptx
... alignment of the fragment 4–7 of the 13 ensemble structures of AII to the fragment 3–6 of the X-ray structure of AII. Fig. 6. Structure of a representative folded conformer of AII showing the van ... to the average co-ordinates (the blue colour denotes the side chains of Arg2, Tyr4, Ile5, His6 and the yellow the side chains of Val3 and Pro7) (a) with the...
Ngày tải lên: 20/02/2014, 23:20