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BIOACTIVE FOOD PEPTIDES IN HEALTH AND DISEASE pot

Modern Nutrition in Health and Disease pot

Modern Nutrition in Health and Disease pot

... historically in the opening chapter and considered in separate chapters on individual essential nutrients and in those on taurine, homocysteine, glutamine, arginine, choline, and carnitine.There are ... histidine is also basic. Other common groupings are the aliphatic or neutral amino acids (glycine, alanine, isoleucine, leucine, valine, serine, threonine and proline). Proline differs in that ... organs in the body, but amino acids are consumed in the diet from a variety of protein sources. In addition, each amino acid is maintained in part as a free amino acid in solution in blood and inside...
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The Neuronal Environment: Brain Homeostasis in Health and Disease pot

The Neuronal Environment: Brain Homeostasis in Health and Disease pot

... HOMEOSTASIS AND NEUROLOGICAL DISEASE Substantial progress has been made in the understanding of the pathophysiology and mechanisms involved in the attenuation of brain homeostasis. In many diseases ... mechanisms, including nitric oxide, adenosine, potassium, and pH(30–35).Finally, vascular (endothelial cells and vascular smooth muscle) and parenchymal(neurons and glia) cells cooperate closely, and ... voltage-dependent ion currents and synaptically mediated excitatory and inhibitory potentials. In principal neocorticalor hippocampal neurons, depolarizing ion conductances involved in action potentialgeneration,...
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Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx

Tài liệu Báo cáo khoa học: TEC family kinases in health and disease – loss-of-function of BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYK pptx

... T-cell kinase (ITK) could in uence the infectivity of HIV and also have anti -in ammatory activity. Since 2006, several patients carry-ing a fusion protein, originating from a translocation joining ... mutation in the BTK PH domain; arginine 28 is in dark blue, encircled in red. Bottom left: SH2 domain. Right: kinasedomain. The mutated residues are indicated in yellow, a-helices are in cyan, ... compilation ª 2011 FEBSMINIREVIEWTEC family kinases in health and disease – loss-of-functionof BTK and ITK and the gain-of-function fusions ITK–SYK and BTK–SYKAlamdar Hussain1,2,*, Liang Yu1,3,*,...
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Tài liệu Aneuploidy in Health and Disease Edited by Zuzana Storchova doc

Tài liệu Aneuploidy in Health and Disease Edited by Zuzana Storchova doc

... regulator of calcineurin 1 (RCAN1) protein at Ser112 and Thr192. RCAN1 is also located in the DSCR. The phosphorylation of RCAN1 enhances RCAN1 binding to calcineurin, resulting in reduced NFAT ... diploid and aneuploid cell lines (Gemoll et al. 2011). Twenty-six spots were identified by peptide mass fingerprinting: eight proteins were higher and 18 lower expressed in the aneuploid than in ... favoring the development of genomic instability and tumor growth (Zhu et al. 2004). The inhibition of HDAC in combination with chemotherapy (doxorubicin) is currently assessed in phase I clinical...
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Báo cáo khoa học: Regulation of matrix metalloproteinase activity in health and disease pdf

Báo cáo khoa học: Regulation of matrix metalloproteinase activity in health and disease pdf

... integrin-binding ligandN-linked glycoprotein (SIBLING)Individual members of the SIBLING family are knownto bind strongly to both pro- and active forms ofspecific MMPs. Bone sialoprotein binds ... proMMP-binding partnersinvolved in activation.Allosteric activationGelatinase interactions with collagen and gelatinBinding of macromolecules or specific thiol-bindingreagents to an MMP with an intact ... activation by binding tothe 64 kDa intermediate form of MMP-2 [52]. Binding and activation of MMP-2 was abrogated in the pres-ence of avb3 integrin-binding macromolecules such asvitronectin and HKa...
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Báo cáo khoa học: Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans ppt

Báo cáo khoa học: Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans ppt

... modulated by lumican-evoked signaling,including vinculin and focal adhesion kinase [82].Lumican alters the relationship between actin filaments and b1 integrin, which in turn would affect focal adhe-sion ... with the EGF-binding domain [32]. Thestructural constraints of the EGFR binding regionsupport a stochiometry of 1 : 1 for the decorin pro-tein core and EGFR, suggesting that decorin is bio-logically ... this RTK [55].By binding to the IGF-IR, decorin triggers phosphor-ylation and downstream activation of phosphoinosi-tide-3 kinase, Akt ⁄ protein kinase B and p21WAF1,inducing an antiapoptotic...
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Báo cáo khoa học: Proteoglycans in health and disease: the multiple roles of syndecan shedding ppt

Báo cáo khoa học: Proteoglycans in health and disease: the multiple roles of syndecan shedding ppt

... HEXXHXXGXXH) and a conserved methionine(Met-turn) supporting the catalytic zinc. Interactionbetween cysteine–zinc maintains proMMPs in an inac-tive state by preventing a water molecule from bindingto ... (GAIP)-interacting C-terminus ⁄synectin and calc ium ⁄ calmodulin-associated serine kinase,since the C2 region contains a class II PSD-95 ⁄Discs-large ⁄ Zonula occludens protein-binding motifFXF, ... (Pro) containing a cysteine switch motifPRCGXPD (except for MMP23 which lacks thecysteine switch motif) that maintains them as inactivezymogens, and a catalytic domain with a z inc-binding site(Zn,...
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Báo cáo khoa học: Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis pptx

Báo cáo khoa học: Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis pptx

... Accumulating evidences indicate thatHSPGs act to inhibit cellular invasion by promotingtight cell–cell and cell–ECM interactions, and by main-taining the structural integrity and self-assembly ... in lungcarcinoma and chronic myeloid leukemia comparedwith control tissue and cells. In this splice variant,144 bp of intron 5 are joined with exon 4, resulting in a 169-amino-acids protein ... head and neck carcinoma inhibits cell growth, motility and invasion in vitro [17]. Similarly, overexpression ofHSulf-1 and HSulf-2 in CAG myeloma cells inhibitstumor xenograft development and...
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The Health Risks and Consequences of Trafficking in Women and Adolescents pot

The Health Risks and Consequences of Trafficking in Women and Adolescents pot

... prevention and returnThe Health Risks and Consequences of Trafficking in Women and AdolescentsFindings from a European Study including:Human Rights Analysis of Health and Trafficking and Principles ... Guide.Vision, Innovation and Professionalism in PolicingViolence Against Women and Children,7InternationalEthical Guidelines for Biomedical Research InvolvingHuman Subjects8 and reporting guidelines ... ways, and maintaining continuity of care.! Women in both integration and reintegration settingsexpressed concerns about their personal safety, and reprisals of traffickers. ! Legal and funding...
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