Báo cáo khoa học: The histone demethylase JARID1A regulates progesterone receptor expression pot

... Journal compilation ª 2011 FEBS 1469 The histone demethylase JARID1A regulates progesterone receptor expression Antje Stratmann 1,2 and Bernard Haendler 1 1 Therapeutic Research Group Oncology, ... trimethylation, mainly at the half-ERE region. The requirement of the demethylase activity for the repressive effects of JARID1A on PR gene expression was furthermore...

Ngày tải lên: 22/03/2014, 16:20

... blots verified the exogenous expression of the ZBP-89 vector (Fig. 1A), and the efficiency of inhibition of ZBP-89 expression by ZBP- 89i (Fig. 1B). The transfected NCI-H460 cells were then lysed ... speculate whether HDAC(s) also plays a role in p16 regulation as the opposing enzyme(s) to the HATs. To test this assumption, we transfected 293T cells with the p16 promoter repor...

Ngày tải lên: 07/03/2014, 02:20

... example and then used to generate a prediction for the left- out example. The meta-classifier is trained using the predictions of the base-level classifiers as features, and the true label as given by the ... Under these re- strictions, RE became an instance of entity labeling, where the label assigned to an entity (e.g. Father) is its relation to the topic of the article. Oth...

Ngày tải lên: 08/03/2014, 01:20

... to the plasma mem- brane. This work clearly indicates that it is the identity of the activated promoter within the hetero-oligomer that determines the fate of the internalized receptors. Other ... examples of the reciprocal influence of receptors in the internalization process are the adrenergic a 1a and a 1b receptors [21], neurokinin NK 1 and l opioid receptors [22], and t...

Ngày tải lên: 16/03/2014, 22:20

... to the TM number, and another (N2) counting the posi- tion relative to the most conserved residue in the particular TM. The conserved locus is assigned the number 50, and the N2 values of the other ... Specific- ally, these positions are: 1.54 and 4.47 in the chemo- kine receptors [49]; 4.58 in the dopamine D 2 receptor [9] and 6.42 in the b 2 -adrenergic receptor [88...

Ngày tải lên: 16/03/2014, 22:20

... derived from the four different groups. Images were scanned and analysed by the Agilent GeneChip Scanner. The original signals of the images were normalized using the reference spots on the slide and the ... regulates the expression of downstream target HBD-2. Therefore, in the present study we initially supposed that (a) HMGN2 elevates the activity of NF-jB, enhances...

Ngày tải lên: 22/03/2014, 16:20

... during(x,y~ or ~(x c y) and then either x = y, i.e. contain(x,yJ or -(x = y) and then either since~x,v~ or until ~x,y) These are the six aspectual values. The reason why the de(eric system has ... time-points, on the one hand the time of the state resulting from a prior situation, and on the other the time of that prior situation.' (ibid., p. 52). In order...

Ngày tải lên: 24/03/2014, 05:21

... of PrP*. ‘Adaptation’ hypothesis There is an alternative hypothesis which postulates that the shortening of the incubation times observed in the second passage of synthetic prions may be attrib- uted ... of synthetic prions? Here, we propose two hypotheses, which reconcile this paradox, and will guide the future studies on production of the next generation of syn- thetic prions. ‘Ma...

Ngày tải lên: 30/03/2014, 09:20

... tunicamycin, on the other hand, strongly induced ERO1-Lb and more moderately ERO1-La expres- sion. The expression of the two ERO1-L isoforms therefore appears to be differently regulated, in the way that ... speculate from these findings that the expression of ERO1-La is probably regulated via the HIF-pathway and thus belongs to the family of classic oxygen regulated genes. Ac...

Ngày tải lên: 31/03/2014, 01:20

... of the porcine histone H1.2 As there is no intron in the genes of histones, the genomic DNA from porcine liver was used as a template to clone the gene of histone H1.2. The human and murine histone ... activity, as well as the full-length histone H1 and the synthetic 36- amino acid peptide around the cleavage site. It would be interesting to further identify the mini...

Ngày tải lên: 16/03/2014, 13:20