... mainly the apoptotic TAisoform(s) and the antiapoptotic DM isoforms. In gen-eral, TAp73 isoforms regulate the transcription of DMp73 isoforms, which, in turn, act as dominant nega-tive regulators ... the 3¢-end (leading to the formation of a, b,c, d, e, f and g isoforms) [8–12]; (b) the use of anextrinsic promoter (P1) and an alternative, intrinsicpromoter (P2) in the 5¢-end (leading to ... and an intrinsic P2promoter, resulting in TAp73 and DMp73 isoforms, respectively. The ulti-mate effect of p73 in oncogenesis is thought to depend on the apoptoticTA to antiapoptotic DN isoforms’...