Báo cáo Y học: Ligand-induced heterodimerization between the ligand binding domains of the Drosophila ecdysteroid receptor and ultraspiracle docx
Báo cáo Y học: Ligand-induced heterodimerization between the ligand binding domains of the Drosophila ecdysteroid receptor and ultraspiracle docx
... Ligand- induced heterodimerization between the ligand binding domains of the Drosophila ecdysteroid receptor and ultraspiracle Markus Lezzi 1 , Thomas Bergman 1, *, ... Further- more, the EcR fragment expressed in yeast was functional and bound radioactively labelled ecdysteroid specifically. Ligand binding was greatly enhanced by the presence of a US...
Ngày tải lên: 18/03/2014, 01:20
Báo cáo Y học: Propionate CoA-transferase from Clostridium propionicum Cloning of the gene and identi®cation of glutamate 324 at the active site pdf
... puri®ed and the gene encoding the enzyme has been cloned and sequenced. The enzyme was rapidly and irre- versibly inactivated by sodium borohydride o r h ydroxyl- amine in the presence of propionyl-CoA. ... (DSMZ, Braunsc hweig, Germany). Synthesis of acyl-CoA substrates Acetyl-, butyryl- and propionyl-CoA were prepared from the corresponding anhyd rides and CoA by th...
Ngày tải lên: 17/03/2014, 17:20
Báo cáo y học: "Does switching from oral extended-release methylphenidate to the methylphenidate transdermal system affect health-related quality-of-life and medication satisfaction for children with attention-deficit/hyperactivity disorder&
... satisfaction with the duration of effect of the study medication on their child's ADHD symptoms. Regarding medication satisfaction with tolerability of MTS, at study endpoint the majority of caregivers ... that the study medication decreased their child's appetite. The majority of caregivers (88.1%) disagreed that the study medication made their child feel slee...
Ngày tải lên: 25/10/2012, 10:06
Báo cáo y học: "Mirror-Image Arachnoid Cysts in a Pair of Monozygotic Twins: A Case Report and Review of the Literature"
... pathogenesis of AC. The findings in our case indicate that early neuroimaging is mandatory in the counterpart of the sympto- matic patient with AC, irrespective of the absence of symptoms. Key words: ... pregnancy of a healthy 24-year-old mother. They have no family history of genetic diseases. Both had Apgar scores of 9/9 at 1 minute and 9/9 at 5 minutes. The...
Ngày tải lên: 25/10/2012, 11:00
Báo cáo y học: "Why are some children with early onset of asthma getting better over the years" -aneuploid-prostate-cancer-cells-after-tmz-tmz-bioshuttle-treatment.html#post143974
... PHC data of the statements made by the mid-wife in her records of the check-up of the mothers during the pregnancy (17). In the follow-up at the age of seven, n= 191 children of the defined ... U, Anderson HR, Burney P. Comparison of asthma prevalence in the ISAAC and the ECRHS. ISAAC Steering Committee and the European Community Respiratory Health Su...
Ngày tải lên: 26/10/2012, 09:48
Báo cáo y học: "Grb2-associated binder 1 polymorphism was associated with the risk of Helicobactor pylori infection and gastric atrophy"
... bind to the SH2 domains. The tandem SH2 domains bind to Tyr-627 and Tyr-659 simultaneously in a specific orientation, in which Tyr-627 binds to the N-SH2 domain and Tyr-659 binds to the C-SH2 ... diagnosis of cancer. In summary, the Gab1 A/A was associated with the low risk of H. pylori infection while the G/A and A/A genotypes together may increase the risk...
Ngày tải lên: 31/10/2012, 15:37
Báo cáo Y học: S-Decyl-glutathione nonspecifically stimulates the ATPase activity of the nucleotide-binding domains of the human multidrug resistance-associated protein, MRP1 (ABCC1) ppt
... University of Groningen, Haren, the Netherlands; 2 Department of Gasteroenterology and Hepatology, University Hospital Groningen, the Netherlands; 3 Department of Medical Oncology, University Hospital ... can be explained by assuming the presence of one high-affinity stimulatory binding site, and one low-affinity inhibitory binding site. These sites may be identical to th...
Ngày tải lên: 17/03/2014, 23:20
Báo cáo Y học: Extra terminal residues have a profound effect on the folding and solubility of a Plasmodium falciparum sexual stage-specific protein over-expressed in Escherichia coli pptx
... The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA The presence of extra N- and C- terminal residues can play a major role in the stability, solubility and ... partially soluble in five of the constructs resulting in very poor yields. Intriguingly, in the sixth con- struct, the yield of soluble fusion protein with an extended carbox...
Ngày tải lên: 23/03/2014, 21:20
Báo cáo Y học: Activation of transcription through the ligand-binding pocket of the orphan nuclear receptor ultraspiracle docx
... Spindler-Barth, M. (2002) Ligand- induced heterodimerization between the ligand- binding domains of the Drosophila ecdysteroid receptor and ultraspiracle. Eur. J. Biochem. 269, 3237–3245. 6036 Y. Xu et al.(Eur. ... strongly indicative that the DNA -binding domain, and the parts of the ligand- binding domain that are outside of the ligand- binding...
Ngày tải lên: 23/03/2014, 21:20
Báo cáo Y học: A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor potx
... modelled the complex of the SOCS-3 SH2 domain and the receptor peptides pY401 and pY429pY431 (Fig. 6). For comparison, Fig. 2. Comparison of SOCS-3 binding to pY343, pY401 and pY429pY431 of the human ... specifically interact with the tyrosine motifs pY401 and pY429pY431. pY429pY431 was more potently recruiting SOCS-3 than pY401, reflecting the high affinity bindin...
Ngày tải lên: 24/03/2014, 00:21