Báo cáo khoa học: Inhibition of the mitochondrial calcium uniporter by the oxo-bridged dinuclear ruthenium amine complex (Ru360) prevents from irreversible injury in postischemic rat heart docx
Báo cáo khoa học: Inhibition of the mitochondrial calcium uniporter by the oxo-bridged dinuclear ruthenium amine complex (Ru360) prevents from irreversible injury in postischemic rat heart docx
... assessing the relevance of mPTP in I⁄ R injury in the intact heart is the Fig. 6. The oxygen-bridged dinuclear ruthenium amine complex (Ru360) does not inhibit calcium movements in sarcoplasmic ... assuming aFig. 4. Perfusion of the oxygen-bridged dinuclear ruthenium amine complex (Ru360) into isolated hearts inhibits the mitochondrial cal-cium uptake. Initial calcium in ux rate of mitochondria ... SRvesicles or in isolated myocytes [15]. To gain insightinto the contribution of the mitochondrial uniporter to myocardial injury during I ⁄ R in isolated hearts,we examined the ability of perfused...
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Báo cáo khoa học: Inhibition of PI3K/Akt partially leads to the inhibition of PrPC-induced drug resistance in gastric cancer cells pdf
... significantly increased. The results indicatethat inhibition of the PI3K/Akt signaling pathwaymay lead to inhibition of the MDR induced by PrPC in gastric cancer cells. The mechanism underlying PI3K/Akt-mediatedPrPC-induced ... in similar releasing rates to each other because of their toxicity effect (P > 0.05) (Fig. 3). The resultsindicated that inhibition of the PI3K/Akt signalingpathway leads to inhibition of ... ismediated by various mechanisms operating at varioussteps in the cytotoxic activity of the drug, from adecrease of drug accumulation in the cell to abrogation of apoptosis induced by the chemical...
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Tài liệu Báo cáo khoa học: Inhibition of cobalamin-dependent methionine synthase by substituted benzo-fused heterocycles pptx
... substrate or cofactor. In detail, the N-terminalmodule is the homocysteine (Hcy)-binding domain; the second domain binds 5-methyltetrahydrofolate, the thirddomain binds CH3-Cbl; and the fourth ... pictures showing the electrostatic surfaces of the methyltetrahydrofolate-binding domain of rat liver MetS (A) with5-methyltetrahydrofolate bound showing the open cleft binding side from a side ... are the subject of continuing investigation in this laboratory.To elucidate further the mechanism of action of the substituted benzo-fused heterocycles, to explore the interactions occurring...
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Tài liệu Báo cáo khoa học: Inhibition of glyceraldehyde-3-phosphate dehydrogenase by peptide and protein peroxides generated by singlet oxygen attack docx
... slow thermal i nactivation.Examination of the role of peroxide-derived radicals in enzyme inhibition To examine whether radical species were generated during the inactivation of GAPDH and L DH by ... inactivation of G APDH being metal-ion independent, whereas inhibition of GR and LDH by H2O2occurs most rapidly in the presence of metal ions.It is proposed that the inhibition of GAPDH and GR by these1O2-generated ... supported by the inefficient inhibition of LDH by theseperoxides, in the absence of metal ions, as this enzyme doesnot contain an active site thiol. The nonradical nature of the GAPDH and GR inhibitio...
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Báo cáo khoa học: Inhibition of recombinant human maltase glucoamylase by salacinol and derivatives pdf
... or by activity in the C-terminaldomain of the full-size protein, thereby accounting for the inhibition by ‘acarbose’ reported previously [28].Our previous studies of the inhibitory effect of ... enzyme inhibition (compare 12 against 13 and 15 in Fig. 1). Following the preliminary screen, each of the four most promisinginhibitors was used in further inhibition analysisto determine their ... affects binding in the activesite will only be possible with an analysis of the atomicstructure of the MGA binding site in both the presenceand absence of bound inhibitor. Determination of thisstructural...
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Báo cáo khoa học: ` Inhibition of human ether a go-go potassium channels by 2+ Ca ⁄calmodulin binding to the cytosolic N- and C-termini potx
... excess of the unlabeledpeptide from the other binding sites (data not shown). The validity of the results obtained for the binding of CaM to the N-terminus of hEAG1 channels wasconfirmed employing ... putativeCaM binding domains in the channel protein. Indeed,we found two more sites, one in the C-terminus neigh-boring to the previously identified site and one domain in the N-terminus of hEAG1. The ... of either the basic arginines or bothphenylalanines (underlined in Fig. 3C) in BD-C2 led toCa2+⁄ CaM insensitivity of hEAG1 channels.Ca2+-dependent binding of hCaM to the N-terminal binding...
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Báo cáo khoa học: Inhibition of the NF-jB transcriptional activity by protein kinase A pot
... withdistinct specificities in various combinations. A commonfeature of the regulation of the NF-jB family is theirsequestration in the cytoplasm as inactive complexes with aclass of inhibitory ... FSK did notinhibit TNFa-induced DNA-binding of NF-jB (Fig. 3D).Thus, it is likely that the inhibitory effect of PKA on NF-jBis not due to the inhibition of DNA-binding activity of NF-jB.PKA ... enhanced or inhibiteddepending on the level of PKA enzyme activity.Induction of C/EBPb3(CCAAT/enhancer-binding pro-tein b) by cAMP/PKA might be involved in cAMP/PKA-mediated inhibition of NF-jB...
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Báo cáo khoa học: Inhibition of a-synuclein fibrillization by dopamine analogs via reaction with the amino groups of a-synuclein Implication for dopaminergic neurodegeneration pot
... Thesedata demonstrate that the inhibition results from spon-taneous oxidation products of these polyphenols,rather than from binding of the aromatic rings.Dopamine-quinone (DAQ) has been reported ... PAGE analysis by redox-cycling staining [20] for detecting quinoproteins(Fig. 4). The quinoproteins of the DA-adduct arelargely involved in the oligomeric forms, while those of other products ... at least three amino groups of ana-Syn molecule are modified by Q or DA to generateimino groups that link to the aromatic ring of quinoneand the side chains of the protein. The NMR experi-ments...
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Báo cáo khoa học: Inhibition of the D-alanine:D-alanyl carrier protein ligase from Bacillus subtilis increases the bacterium’s susceptibility to antibiotics that target the cell wall potx
... 5¢-O-[N-(D-alanyl)-sulfamoyl]adenosine (5) in vitro and its effecton cell growthTo test the quality of inhibition by 5, the Kiwas deter-mined. For this purpose, the concentration of 5 wasvaried while the concentration of ... The Kmvalue of DltA for d-Ala was subse-quently determined by varying the d-Ala concentrationbetween 1 and 1000 lm. The resulting Km of 13.62 ± 4.18 lm (Fig. 3) is well in the range of the ... efficiently block the aminoacyl adenylation step catalyzed by DltA. The design of the inhibitor was encouraged by the knowninhibitors of aaRS [21–25]. These inhibitors were5¢-O-[N-(aminoacyl)-sulfamoyl]...
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Tài liệu Báo cáo khoa học: Roles of AP-2 transcription factors in the regulation of cartilage and skeletal development doc
... helix–span–helix domain at the C-terminus shown in blue medi-ates dimerization and, together with the basic domain, (red) DNA-binding. ‘*’, amino acids that are identical in all sequences in the align-ment; ... AP-2b, expression in murine limbs has also beendemonstrated. AP-2b is expressed in the zone of polar-izing activity (ZPA), the signaling center of the devel-oping vertebrate limb [68]. A microarray ... genetic diseases[47].Most analyses of the regulation of AP-2 and the interactions of the transcription factor with bindingpartners, as well as of the regulation of target geneexpression, have...
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Từ khóa: báo cáo khoa học mẫubáo cáo khoa học y họcbáo cáo khoa học sinh họcbáo cáo khoa học nông nghiệpbáo cáo khoa học lâm nghiệpbáo cáo khoa học thủy sảnBáo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Báo cáo quy trình mua hàng CT CP Công Nghệ NPVchuyên đề điện xoay chiều theo dạngBiện pháp quản lý hoạt động dạy hát xoan trong trường trung học cơ sở huyện lâm thao, phú thọGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitPhối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhTrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Nghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXChuong 2 nhận dạng rui roQuản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)Nguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀM