... demonstrated the safetyand efficacy of adeno-associated virus (AAV)-mediatedcalpain 3 cDNA transfer in a mouse model of LGMD 2A [26]. However, gene therapy still has someobstacles that remain to ... Sorimachi H, Toyama-Sorimachi N, Saido TC,Kawasaki H, Sugita H, Miyasaka M, Arahata K,Ishiura S & Suzuki K (1993) Muscle-specific calpain,p94, is degraded by autolysis immediately after transla-tion, ... It has been suggested that the smallsubunit may act as a chaperone or that dissociationfrom the catalytic subunit is part of the activation pro-cess of the ubiquitous calpains [19,20]. Therefore,...