Báo cáo khóa học: Endoplasmic reticulum-associated degradation of glycoproteins bearing Man5GlcNAc2 and Man9GlcNAc2 species in the MI8-5 CHO cell line docx
Báo cáo khóa học: Endoplasmic reticulum-associated degradation of glycoproteins bearing Man5GlcNAc2 and Man9GlcNAc2 species in the MI8-5 CHO cell line docx
... Endoplasmic reticulum-associated degradation of glycoproteins bearing Man5GlcNAc2 and Man9GlcNAc2 species in the MI8-5 CHO cell line Franc¸ois Foulquier, Sandrine Duvet, Andre´Klein, Anne-Marie ... converted into Man4Glc-NAc2, in contrast with the small amount of Man6GlcNAc2originating from the Man9GlcNAc2 species. ERAD of glycoproteins bearing Man5 and Man9populations in MI8-5 cells The N-glycosylation ... obtained with the glycoproteinpattern. This indicates that, when glycoproteins bearing Man9 and Man5 are synthesized in the same cell line, those bearing Man5 are more efficiently degraded.Furthermore,...
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Tài liệu Báo cáo khoa học: Altered inactivation pathway of factor Va by activated protein C in the presence of heparin doc
... activity of the reactionintermediate, FVaint. This facilitated the determination of loss of FVa cofactor activity during the initial stage of inactivation and minimized the in uence of the k306Table ... Arg506.Fig. 4. Kinetic analysis of the inactivation of FVa by APC in the pres-ence and absence of heparin. Initial rates of FVa inactivation weredetermined at various concentrations of FVa in the presence ... that the inhibition of APC-mediated FVainactivation by heparin is related to the ability of heparinto bind APC, we used recombinant mutants of APCharboring mutations in the heparin-binding...
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Báo cáo khoa học: RNA-binding properties of HCF152, an Arabidopsis PPR protein involved in the processing of chloroplast RNA pdf
... petB, and to domain IV of the petB intron. The binding of the homodimer of HCF152 in this region somehow stabilizes the splicingproducts, possibly by folding the RNA into the correctsplicing ... located at the C-terminus of the protein although binding of the C-terminus half (CH) isonly half of the full-length protein (Fig. 3). Interestingly, the binding efficiency of the full-length mutant ... analysis of the BDd RNA, the high affinity binding molecule.Defining the binding site of HCF152 in the psbH-petBtranscript In order to further characterize the HCF152 binding site, wesynthesized...
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Báo cáo khoa học: Specific degradation of H. pylori urease by a catalytic antibody light chain pptx
... changes of the band pattern wereobserved. The bands of partially dissociated urease(ambn) became faint as well as the band of the b-subunit monomer. In contrast, the intensity of the band (1; ... (lane 3), the band of the b-subunit became very faint. Some new bands between bands 1 and 2 became clearer and severalbands around bands 4 and 5 also became darker. The band strength of the b-subunit ... mixing (lane 1). At 4 h of incubation (lane 2), the bands of partially dissociated urease (ambn) became faint aswell as the band of the b-subunit monomer. In contrast, the intensity of the...
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Báo cáo khoa học: Calpain-mediated degradation of reversibly oxidized protein-tyrosine phosphatase 1B docx
... in the absence of calpain (Fig. 5). Appar-ently, calpain affects the strength of insulin signalingto AKT, and p70-S6 kinase. The detailed mechanism and the further biological consequences of ... role of calpain in insulin signaling. Target phosphorylation of insulinwas reduced in calpain-negative cells (capn4 knockoutMEFs) and restored upon lentiviral introduction of calpain. Because insulin ... differentinteracting partners and, in transmembrane PTPs,ligand binding [2–6]. In addition, the chemical proper-ties of the catalytic center cysteine of classical PTPsallow for yet another mode of...
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Tài liệu Báo cáo khoa học: Glycomics-based analysis of chicken red blood cells provides insight into the selectivity of the viral agglutination assay docx
... protons of GlcNAc, and the H3-equitorial and H3-axial protons of N-glycolylneuraminic acid[23–26]. The 1H-NMR spectrum of cRBCs within the region of interest is shown in Fig. 3 and the list of important ... treatment of the collected pools to determine the distribution of sialicacid. Next, we completed online MS ⁄ MS analysis of the major species; some of these species were furtheranalyzed by TOF ⁄ TOF ... as the degree and extent of branching and the relativeabundance of a2 fi 3 and a2 fi 6 terminal sialic acidsbetween cRBCs and HBEs, the present study providesinsights into the inability of some human-adapted...
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Báo cáo khoa học: "Weakly-Supervised Acquisition of Open-Domain Classes and Class Attributes from Web Documents and Query Logs" pot
... particular choice in the number of seed attributes, and in the source of instances passed as input to the system:• number of input seed attributes: seed attributesare provided either for each of the ... class label, and consists of four stages:1) identification of a noisy pool of candidate at-tributes, as remainders of queries that also containone of the class instances. In the case of the classmovies, ... for the sets of instances. Comparatively, the open-domainclasses extracted in our paper have an explicit la-bel in addition to the sets of instances, and do notrequire identifying the range of...
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Báo cáo khoa học: "LANGUAGE SYNTHESIS GENERATION OF GERMAN FROM CONCEPTUAL STRUCTURE: MT PROJECT IN A JAPANESE/GERMAN" pot
... REFERENCING AND FOCUSSING For referencing and other phenomena like focussing, the simple approach of only allowing a schema instance as a filler is not sufficient. We therefore included in our ... feasibility of the approach of using a semantic representation as an interlingua in a practical application will be investigated and demonstrated by translating titles of Japanese papers from the ... for semantic synthesis. The project is funded by the "Informationslinguistik" program of the Ministry for Research and Technology (BM~T), FRG, and is carried out in cooc~ration with...
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Báo cáo khoa học: Ternary complex formation of pVHL, elongin B and elongin C visualized in living cells by a fluorescence resonance energy transfer–fluorescence lifetime imaging microscopy technique docx
... was induced by binding of elongin B. The conformational change of elongin C was investigated bymeasuring changes in the intramolecular FRET signal of elongin C linked tocerulean and citrine ... FLIM analysis of interaction between elongin B and elon-gin C in CHO- K1 cells. (A) Cellular localization of elongin B linked tocerulean and elongin C linked to citrine. Chimeric proteins, ceru-lean-elongin ... citrine-linked elongin C can be detected in the fol-lowing donor-acceptor combinations in decreasingorder: cerulean-elongin B and citrine-elongin C >cerulean-elongin B and elongin C-citrine...
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Báo cáo khoa học: Proteomic identification of all plastid-specific ribosomal proteins in higher plant chloroplast 30S ribosomal subunit PSRP-2 (U1A-type domains), PSRP-3a/b (ycf65 homologue) and PSRP-4 (Thx homologue) doc
... N-terminal motifs are involved in ribosome binding, and three of the C-terminal domains are required for mRNArecognition [6,75,76], with the last domain involved in the autoregulation of S1 ... PSRP-2 contains twoRNA-binding domains which occur in mRNA processing/stabilizing proteins (e.g. U1A snRNP, poly(A)-bindingproteins), suggesting a possible role for it in the recruiting of stored ... regulatingprotein synthesis in a more global manner, e.g. respondingto the diurnal light and dark cycle and the consequentrapidly changing ATP/GTP levels in the organelle, and meeting the high...
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