... University of Melbourne, Australia2 The Mental Health Research Institute of Victoria, Parkville, Australia3 Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA, USAIntroductionAlzheimer’s ... and Fe, considerable data indi-cates a loss of Zn homeostasis in AD. Abnormallyhigh concentrations of Zn are associated with amyloidplaques in AD brain [17,37,38] and AD Tg mice [39].In a ... of Abproduction, and an increase in tau hyperphosphoryla-tion. Furthermore, an increase in extracellular metalscan catalyse Ab oligomerization and aggregation, andthe amyloid plaques that...