Báo cáo khoa học: RCAN1-1L is overexpressed in neurons of Alzheimer’s disease patients pot

... contain any vesicu- lated peroxisome (Fig. 6A,D,E). The drastic phenotype of Dlpx1 is reminiscent of the peroxisomal morphology found in peroxisomal disorders. Discussion Lpx1p is a peroxisomal ... for Lpx1p in peroxisome function. The morphological defect found in electron microscopic images of a deletion of Lpx1p (peroxisomes containing inclusions or invaginations) is sy...

Ngày tải lên: 07/03/2014, 05:20

... or hydrogen bond interactions of the side chains. From this analysis, it is interesting to see a large number of interhelical stabilizations through SC-SC SHBs. Exam- ples of helix–helix interaction ... bonds, there is no such well-defined force existing between interhelical inter- actions found in large helical bundles. The stability of helix–helix interacting motifs is due to...

Ngày tải lên: 07/03/2014, 17:20

... elements of Slc12a2 gene promoter. Our results showed that the number of Six1-binding sites is at least three, whereas there is one Six4-binding site, indicating that the DNA-binding specificity of ... sequences of Six1 and Six4 As for the recognition sequence of Six1, which were identified in this study, it is difficult to predict the con- sensus sequence of the binding site...

Ngày tải lên: 07/03/2014, 17:20

... importin b binding (IBB) domain in its N-terminus and the C-terminal NLS- binding domain. In the absence of importin b,an auto-inhibiting part of the IBB domain forms an intra- molecular interaction ... common characteristics of these sequences are (i) a high content of basic amino acid residues such as lysine (K) and arginine (R), and (ii) the presence of conserved pro- line(s)...

Ngày tải lên: 15/03/2014, 11:20

... Ray SK (2008) New insights into the roles of endolysosomal cathepsins in the pathogenesis of Alzheimer’s disease: cathepsin inhibitors as potential therapeutics. CNS Neurol Disord Drug Targets ... S, Kametani F, Saito Y & Murayama S (2006) Beta-site APP cleaving enzyme 1 (BACE1) is increased in remaining neurons in Alzheimer’s disease brains. Neurosci Res 54, 24–29. 3...

Ngày tải lên: 07/03/2014, 00:20

... of subsequent investigations [3,9], involving an impressive range of odorants and reporting a number of stimulating odorants. This raises the possibility that the receptor itself is capable of ... different coding of the olfactory information in terms of odorant concentration. This may arise from a modulation of the odorant–receptor interactions depending on odorant chain le...

Ngày tải lên: 08/03/2014, 02:21

... with the C-terminal d 1 heme-containing domain of cytochrome cd 1 . Strikingly, the axial ligand of iron in d 1 heme in P. pantotrophus cd 1 (His200) is conserved in NirF (His41); this conservation ... d 1 heme. Replacement of an equivalent His, His41, in NirF by Ala abolished binding of the heme to the protein. Known distal heme-binding residues, such as Met, Lys or Cys [18...

Ngày tải lên: 15/02/2014, 01:20

... effects of visfatin were abolished when insulin receptor signalling was blocked [8], in line with the report that visfatin could bind and activate insulin receptors [14]. However, the insulin- mimetic ... also increased (Fig. 1G,H). Taken together, these data AcLDL 1 2 Visfatin/cyclophilin mRNAVisfatin/cyclophilin mRNA Visfatin/cyclophilin mRNA CD36/cyclophilin mRNA FABP4/cyclophilin mRNA...

Ngày tải lên: 06/03/2014, 22:21

... vector pQCXIN, pQCXIN-NANOGP8 and pQCXIN-NANOGP8-GFP using Lipofectamine TM 2000 according to the manufac- turer’s instructions. Stable clones were selected and isolated in media containing 500 ... was not transcribed in OS732. Thus, it is likely the protein of NANOGP8 and ⁄ or Nanog was detected in cancer line HepG2 and the protein of NANOGP8 was found in cancer line OS732 usin...

Ngày tải lên: 07/03/2014, 12:20

... his3:hisG/his3::hisG trp1::hisG/trp1::hisG This study MR211 S1278b; MATa ura3–52 his3:hisG leu2::hisG ras2::kanMX MR298 S1278b; MATa/a ras2::kanMX/ras2::kanMX ura3–52/ura3–52 his3:hisG/his3:hisG leu2::hisG ... his3:hisG/his3:hisG leu2::hisG leu)2::hisG This study AR2 S1278b; MATa/a sut2::S.pombe his5 + /sut2::S.pombe his5 + ura3–52/ura3–52 his3:hisG/his3:hisG leu2::hisG/LEU2 TRP1/trp1::hisG T...

Ngày tải lên: 07/03/2014, 15:20