Báo cáo khoa học: Residues affecting the chloride regulation and substrate selectivity of the angiotensin-converting enzymes (ACE and ACE2) identified by site-directed mutagenesis pot
Báo cáo khoa học: Residues affecting the chloride regulation and substrate selectivity of the angiotensin-converting enzymes (ACE and ACE2) identified by site-directed mutagenesis pot
... ª 2008 The Authors Journal compilation ª 2008 FEBS Residues affecting the chloride regulation and substrate selectivity of the angiotensin-converting enzymes (ACE and ACE2) identified by site-directed ... observed. Results PCR mutagenesis of CL1 and CL2 site residues of tACE and ACE2 The residues surrounding the chloride ion at the...
Ngày tải lên: 16/03/2014, 04:20
Tài liệu Báo cáo khoa học: Multiple promoters regulate tissue-specific alternative splicing of the human kallikrein gene, KLK11⁄hippostasin ppt
... the regulation and characteristics of these isoforms are unknown. We identified the first three exons (1a, 1b, and 1c) by determining their transcription initiation sites. Exon 1b con- tained the ... RT-PCR to study the tissue-specific use of each promoter. We show the translation initiation site of isoform 2 and different intracellular distribution of isoforms 1 a...
Ngày tải lên: 19/02/2014, 06:20
Tài liệu Báo cáo khoa học: "Exploiting Readymades in Linguistic Creativity: A System Demonstration of the Jigsaw Bard" docx
... the scale of the Bard’s genera- tivity, and the quality of its insights. 5 Empirical Evaluation The vastness of the web, captured in the large- scale sample that is the Google ngrams, means the Jigsaw ... instances of the patterns “as ADJ and * as” and “as * and ADJ as” from Google, noting the combinations that are found and their frequencies. These frequ...
Ngày tải lên: 20/02/2014, 05:20
Báo cáo khoa học: Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis docx
... between the cytoplasmic surfaces of myoblast and myotube NPCs and a correlation between the copy number of Nup358 and the NPC structure. Furthermore, small interfering RNA- mediated depletion of Nup358 ... S2C). The upper rim diameter of the NPC increased by approxi- mately 9 nm during myotube formation, whereas the outer diameter and the height of the NPC...
Ngày tải lên: 06/03/2014, 01:20
Báo cáo khoa học: b-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins pot
... investigated the effects of genetic manipulation of BACE1 on the processing of the APP family of proteins. BACE1 expression regulated the levels and species of full-length APLP1, APP and APLP2, of their ... in both the peripheral and central nervous systems [6]. In the former, they are involved in the formation and correct functioning of the neuromuscular...
Ngày tải lên: 15/03/2014, 10:20
Tài liệu Báo cáo khoa học: Accessibility changes within diphtheria toxin T domain when in the functional molten globule state, as determined using hydrogen⁄deuterium exchange measurements pdf
... define the core of the protein’s N state [21]. For the T domain, these were the center of TH5 and TH8, and the N-terminal half of TH9. All a-helices (TH1, 3, 4, 5’, 6, 7 and the remaining parts of TH5 ... in the N state and the evolution of the overall structure of the protein in the MG state. This degree of resolution is unprecedented for the T do...
Ngày tải lên: 16/02/2014, 09:20
Tài liệu Báo cáo khoa học: Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2? docx
... evidence for an interaction between the two domains is the ability of numerous substrates and modulators of ABCG2 (and the R482G isoform) to stimulate the rate of ATP hydrolysis [21,24,25], albeit ... because of its higher potency. Figure 1B dem- onstrates the ability of the nucleotides to reduce the fraction of [ 3 H]daunomycin bound to ABCG2 R482G .In the pres...
Ngày tải lên: 18/02/2014, 18:20
Tài liệu Báo cáo khoa học: What makes biochemical networks tick? A graphical tool for the identification of oscillophores ppt
... each other). The value (the sign) of a cycle is the product of the values (the signs) of its steps. The sign o f the magnitude of a Ôminus combined autoinfluence path of order pÕ equal those of the ... The absolute magnitude of a combined autoinfluence path is the product of all the rates divided by the product of all the concentrations of its speci...
Ngày tải lên: 19/02/2014, 16:20
Tài liệu Báo cáo khoa học: "A Method for Correcting Errors in Speech Recognition Using the Statistical Features of Character Co-occurrence" pptx
... arbitrary candidates, when one of their Error-Parts includes the other, and their frequencies are the same value, the candidate whose Error-Part includes the other is accepted. Condition of Inclusion-2: ... In all other cases, go to the step for a middle. Here, P1 and P2 denote the start and end positions of an error-block, and L denotes the length of the...
Ngày tải lên: 20/02/2014, 18:20
Báo cáo khoa học: Factors affecting habituation of PC12 cells to ATP potx
... defined as the ratios of the amplitude of each response (B,C,D,E) in the run to the amplitude of the initial r esponse of that run (B). Habituation w ill be recorded in text as a percentage of the fourth ... Norepi- nephrine standards were used to determine the response of the d etector and the dispersion of ATP and its analogs during stimulation. These t es...
Ngày tải lên: 07/03/2014, 16:20