Báo cáo khoa học: Nucling interacts with nuclear factor-jB, regulating its cellular distribution potx

... apparently overlapped with that of Nucling (Fig. 5B,F) or NuclingDC (Fig. 5C,G), but not with that of NuclingDN (Fig. 5D,H), suggesting that Nucling interacts with NF-jB through its N-ter- minal region, ... article. Nucling regulates cellular distribution of NF-jB L. Liu et al. 1470 FEBS Journal 276 (2009) 1459–1470 ª 2009 The Authors Journal compilation ª 2009 FEBS Nucli...

Ngày tải lên: 16/03/2014, 04:20

... CD91 interacts with MBL at or near the MASP-binding site. (A) Using SPR, 6 n M of MBL was injected over a sensor chip on which CD91 was immobilized (16 000 RU), with or without preincu- bation with ... the binding sites on C1q for CD91 were shared with calreticulin [19]. Here, it is shown that CD91 interacts directly with MBL and, to a lesser extent, with L-ficolin and there- f...

Ngày tải lên: 06/03/2014, 01:23

... NBR1, when coexpressed with nuclear CIB however, retained its perinuclear, cytoplasmic location. A s imilar shift in CIB e xpression pattern to the ER compartment was ob served with the presenilin ... wide variety o f cellular processes, including signal transduction pathways regulating cell proliferation, differentiation and apoptosis. FEZ1, by its interaction with PKC f via...

Ngày tải lên: 08/03/2014, 10:20

... using a candidate protein approach. It remains possible that Evi1 interacts with as yet unknown cellular proteins responsible for regulating biological activity. To investigate this, we screened ... that interacts with the N-terminus of the androgen receptor [28]. Interestingly, enforced expres- sion of UXT ⁄ ART-27 in LNCaP prostate cancer cells inhibits proliferation and further...

Ngày tải lên: 16/03/2014, 11:20

... Biochemical analysis of cellular fractionation assays revealed that the two proteins are p redominantly associated with the particulate fraction of transfected cells (data not shown). This result, together with ... indicate that dematin does not directly interact with Ras-GRF1, dematin may indirectly recruit GRF1 to the actin cytoskeleton via its association with Ras-GRF2. It is t...

Ngày tải lên: 17/03/2014, 11:20

... arranged in tandem at its N-terminus and a protein-binding aux- iliary domain at its C-terminus. Concurrently, PABP exhibits preferential affinity for poly(A) stretches and also interacts with several ... radiolabelled ARS RNA with 0.1 M NaOH. Lane 2 and 3, 5¢ end radiola- belled ARS RNA with or without purified 6· His-IMP1, respectively. Lanes 4 and 5, 5¢ end radiolabelled ARS RNA...

Ngày tải lên: 23/03/2014, 10:20

... question of whether Nop53p also interacts with TRAMP subunits. The TRAMP subunit Trf4p was therefore fused to GST, expressed in Escherichia coli, and its interaction with Nop53p tested through GST ... to bind 5.8S rRNA, and its depletion leads to accumulation of 7S, a phenotype similar to that caused by the depletion of core exo- some subunits [31]. Nop53p interacts with the nuc...

Ngày tải lên: 30/03/2014, 04:20

... PR with the V32I mutation; PR I50V , PR with the I50V mutation; PR I54M , PR with the I54M mutation; PR I54V , PR with the I54V mutation; PR I84V , PR with the I84V mutation; PR L90M , PR with ... compared with PR WT –SQV. (B) PR I50V –APV compared with PR I50V –SQV. (C) PR I54M –APV compared with PR I54M –SQV. (D) PR I54V –APV compared with PR I54V –SQV. (E) PR I84V –APV...

Ngày tải lên: 18/02/2014, 04:20

... correlate each gene with its enzymatic activity. In contrast with all tyrosinases so far studied, the enzyme NP_518458 shows higher monophenolase than o-diphenolase activity and its initial activity ... the proton acceptor residue necessary to with- draw the phenolic hydrogen for its co-ordination to the CuB [32], another residue must obey this role. Its identity is not known. A...

Ngày tải lên: 19/02/2014, 07:20

... a pattern with which to expand it and then filling out that pattern with words drawn from a unigram distribution. This kind of coupled generative process can be naturally formalized with tree ... 1). 489 A weighted tree transducer may define a probabil- ity distribution, either a joint distribution over input and output pairs or a conditional distribution of the output given the in...

Ngày tải lên: 19/02/2014, 19:20