Báo cáo khoa học: Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotype pptx

... erva- tamin-A, the P3 moiety of both the molecules of the asymmetric unit runs along the extended backbone of residues 65–64 and is partly exposed to the solvent (Fig. 2B). On the other hand, the P3 ... at the bottom of the subsite is conserved in ervatamins. Compared to a Ser in the equivalent position of papain, the role of Leu here is to restrict the s...

Ngày tải lên: 18/02/2014, 16:20

... 7. The arrows labeled (b) and (c) point to the areas of interaction between the transmembrane helix of subunit 8 and helices G and H1 of cytochrome b and between the N-terminus of subunit 8 and ... panels A and B and the relative amounts of each of the subunits determined by densitometry scanning of the stained Western blots of the q° and CKL57...

Ngày tải lên: 19/02/2014, 12:20

... The main chain nitrogens of residues I322 and I303 interact with nitrogen atoms of the adenine ring and the c-carboxyl group of the side chain of residue D302, the d and x nitrogen atoms of the ... to homogeneity. The kinetic constants for conversion of the substrate oxalyl coenzyme A by the enzyme in the absence and presence of the inhibitor coenzy...

Ngày tải lên: 06/03/2014, 11:20

... plate- lets and endothelial cells. The important role of these glycans in pharmacokinetics has been demonstrated by the slower and smaller increment of FDP in vivo after the injection of desialylated ... analyses of the glycan epitopes Samples of 7 lg of RVV-X and 5 lg of BSA were analysed by 8% SDS-PAGE under reducing conditions. Appropriate amounts of Le x/a -...

Ngày tải lên: 07/03/2014, 06:20

... the cytosol. This observation allows the further determination of the concentration of drug free in the cytosol of resistant cells. The determination of k a requires also the measurement of the ... Na + -buffer on the one hand and K + buffer on the other hand. In Na + -buffer a strong decrease of the fluorescence signal was observed due to the accumula- tion...

Ngày tải lên: 08/03/2014, 08:20

... observation of the protein’s influence on the progression of the cell cycle and the silica biogenesis. As the regulation of NR expression appears to be very similar throughout the diatom realm [12,13], the ... genes. Furthermore, the addition of both nitrate and appro- priate concentrations of ammonium allows, within lim- its, the control of the amount of...

Ngày tải lên: 07/03/2014, 21:20

... inversion, etc. The LDD on the web: The two primary purposes of the web-interface are to allow the user to interactively peruse the patterns and the derivations that the LDD contains and to download ... outcome and do not have access to the on-line operations of the parser. Originally, the ability to detect ambiguity was employed in two variations of t...

Ngày tải lên: 08/03/2014, 04:22

... Substitutions include the semantics of the idiom, which are supposed to take the place of the literal semantics, plus the specfication of the new Main and of the bindings for the functions. New ... form of the verb. The fwst portion of the representation is devoted to the literal interpretation of the word, and includes the semantic represent...

Ngày tải lên: 08/03/2014, 18:20

... of bovine prothrombin fragment 1 in complex with Ca 2+ [41], the 10 ⁄ 12 site resides near the x-loop and the linear array of bound calcium ions of the Gla domain. Indeed, the importance of the 10 ... evaluated [11]. Of the Gla residues, nine are strictly conserved through- out the Gla proteins. From crystal structures of the Gla domain of prothrombin and f...

Ngày tải lên: 18/02/2014, 06:20

... in terms of its ability to enter the cells of the retina, the present study used reti- nal pigment epithelial (RPE) cells as a model to deter- mine the susceptibility and the mediators of HSV-1 entry ... post-transfection, the target and the effector cells were mixed together (1 : 1 ratio) and cocultivated in 24-well dishes. The activation of the reporter lucif...

Ngày tải lên: 18/02/2014, 14:20