Báo cáo khoa học: Cross-species divergence of the major reco

Báo cáo khoa học: Cross-species divergence of the major recognition pathways of ubiquitylated substrates for ubiquitin⁄26S proteasome-mediated proteolysis potx

... a cross-species mechanistic and functional divergence of the major recognition pathways for the ubiquitylated substrates of UPP. Results Divergence of the ubiquitin binding properties of the major ... loss of function support a major role for Arabdopsis RPN10 in the direct and indirect recognition of ubiquitylated substrates The multiplici...

Ngày tải lên : 15/03/2014, 09:20

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Tài liệu Báo cáo khoa học: Poly(ADP-ribose) The most elaborate metabolite of NAD+ Alexander Burkle pptx

... PARG isoforms targeted either to the nucleus or to the cytoplasm [47]. Overexpression studies revealed that the largest iso- form of PARG is targeted to the nucleus while the two smaller isoforms ... within the known members of the PARP family. Adjacent to the ANK domain is another protein interaction motif, the sterile alpha- module. The C-terminus of tankyrase di...

Ngày tải lên : 20/02/2014, 01:20

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Tài liệu Báo cáo khoa học: Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase Structure of the reduced enzyme-progesterone complex and the roles of residues Tyr186, His181 and His184 pdf

... sub population of enzyme binds directly the steroid in the reactive conformation, with the remainder of the enzyme binding the unreactive conformation. Rescue of the unreactive conformation involves ... re-oxidation of the ﬂavin and the formation of the hydride-Meisenheimer complex of TNT. (C) As for panel B except the spectral changes are recorded over an ex...

Ngày tải lên : 20/02/2014, 02:21

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Báo cáo khoa học: A region within the C-terminal domain of Ure2p is shown to interact with the molecular chaperone Ssa1p by the use of cross-linkers and mass spectrometry doc

... Ssa1p binds a hexameric form of Ure2p in the presence of ATP, whereas the form that is bound in the presence of ADP is different, and probably dimeric [6]. We therefore performed Ure2p and Ssa1p ... built from the X-ray structure of the C-terminal domain of Ure2p and integrates the ﬁnding that the N-terminal domain of Ure2p is ﬂexible. An enlargement of the reg...

Ngày tải lên : 15/03/2014, 00:20

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Báo cáo khoa học: Structural features in the C-terminal region of the Sinorhizobium meliloti RmInt1 group II intron-encoded protein contribute to its maturase and intron ppt

... [10,11]. Biochemical analyses of LtrA mutants (the IEP of the Ll.ltrB intron of Lactococcus lactis) have suggested that the N-terminus of the RT domain is required for protein interactions with the high-afﬁnity ... region. Effect of mutations in the C-terminal region of the RmInt1 IEP on RNA splicing in vivo We constructed a series of mutants to identify the fun...

Ngày tải lên : 15/03/2014, 09:20

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Báo cáo khoa học: Intermodule cooperativity in the structure and dynamics of consecutive complement control modules in human C1r Structural biology docx

... duplicate copies within the C1 complex, forming a tetramer. Both the autoactivation of C1r and the activation of C1s require large-scale move- ments of the different domains of the proteases. Inter- modular ... FEBS under the conditions applied and therefore the constructs could be reliably used to assess the interde- pendence of the modules. This was corroborate...

Ngày tải lên : 15/03/2014, 23:20

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Báo cáo khóa học: Mechanistic insight into the peroxidase catalyzed nitration of tyrosine derivatives by nitrite and hydrogen peroxide doc

... to the afﬁnity of nitrite for the protein site where it is transformed into the nitrating species, in the presence of the phenol. Interestingly, these constants resemble the reciprocal of the nitrite ... Taglietti (University of Pavia) for assistance in the stopped-ﬂow experiments, and Antonella Profumo (University of Pavia) for the determination of the r...

Ngày tải lên : 16/03/2014, 16:20

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Báo cáo khoa học: Sulfated polysaccharides inhibit the catabolism and loss of both large and small proteoglycans in explant cultures of tendon doc

... it is therefore likely that the outcome of the inhibition of aggrecanase activity in tendon is the retention of large proteoglycans within the extracellular matrix of the tissue [22–27]. The mechanism ... inclusion of these sulfated agents there was signiﬁcant inhibition (40%) of rate of loss of 35 S-labeled large proteoglycans from the matrix by the end of...

Ngày tải lên : 23/03/2014, 10:21

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Báo cáo khoa học: "Smart Paradigms and the Predictability and Complexity of Inﬂectional Morphology" docx

... rates for the code can be higher than the numbers of forms in the full-form lexicon is explained by the fact that the gener- ated forms are longer than the base forms. For instance, the full-form ... http://www.eecs. qmul.ac.uk/ ˜ mpurver/software.html one third of the nouns of the lexicon were not in- cluded in the experiment because one of the form was miss...

Ngày tải lên : 24/03/2014, 03:20

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Báo cáo khoa học: Metal ions modulate the folding and stability of the tumor suppressor protein S100A2 docx

... meaningful informa- tion on the thermodynamic stability of the Ca 2+ - and Zn 2+ -loaded mutants can be retrieved from the anal- ysis of metallation effects within the background of the same mutation ... aggregation. The formation of insoluble b-sheet-containing aggregates is most certainly an important contributor to the irreversibility of the ther- mal denaturation...

Ngày tải lên : 30/03/2014, 02:20

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