Targeting multidrug resistance in cancer pptx

... Vinca alkaloids Anthra- cyclines Epipodo- phyllotoxins Taxanes Kinase inhibitors Campto- thecins Thiopurines Other Vinblastine Vincristine Daunorubicin Doxorubicin Epirubicin Etoposide Teniposide Docetaxel Paclitaxel Imatinib (Gleevec) Flavopiridol Irinotecan ... (biricodar) increases drug retention and enhances chemosensitivity in resistant cells overexpressing P-glycoprotein, multidru...

Ngày tải lên: 15/03/2014, 01:20

... reported. In medicine, recognition that many randomized clinical trials were not being reported in a manner that allowed independent evalua- tion led to calls for reform, culminating in the original ... Therapy emphasized reducing denial while preserving hope, completing unfinished business, and taking an active role in treatment deci- sions, but “above all else, simply listening, und...

Ngày tải lên: 15/02/2014, 05:20

... Guanine nucleotide-binding protein (G protein), c11 22 PQBP1 NM_005710 2.232 Polyglutamine-binding protein 1 23 FKBP9 NM_007270 2.212 FK506-binding protein 9 24 PSPHL NM_003832 2.212 Phosphoserine ... complementarily, in the emergence and development of drug resistance in cancers. Although some advances in cancer drug resistance research have been made, indicating that ATP-binding...

Ngày tải lên: 06/03/2014, 22:21

... 575 nm. (A) Fluorescence intensity analysis of intracellular adriamycin in gastric cancer cells. (B) Adriamycin releasing index of gastric cancer cells. The releasing index = (accumulation value ... were maintained in RPMI-1640 containing 10% heat-inactivated newborn bovine serum (SiJiQing, Hangzhou. China) at 37° C in a humidified atmosphere of 5% CO 2 and 95% air. Double immunofluor...

Ngày tải lên: 07/03/2014, 03:20

... their main roles focus on ectodomain shedding and nonpro- teolytic functions, such as binding to adhesion mole- cules, integrins and interacting with phosphorylation sites for serine ⁄ threonine ... key roles in cancer progression. However, in most cases, the agents targeting MMPs exhibited poor performance in clinical trials, in contrast to their promising activity in many prec...

Ngày tải lên: 15/03/2014, 00:20

... childhood cancer include genetics, infections, hormones and radiation. 1 Incidence Cancers in children aged less than 15 years old are rare, causing less than 1% of all cancers in industrialised ... National Institute for Health and Clinical Excellence Improving Outcomes in Children and Young People with Cancer Background 1 Guidance on cancer services: cancer in children and...

Ngày tải lên: 22/03/2014, 16:21

... QORH into the inner enve- lope of chloroplasts was shown to depend on targeting information present in the C-terminus of the pre- protein [11]. Therefore, we constructed a pTic22DC mutant in which ... incubated with the matrix for 45 min. Unbound preproteins were washed off and bound preproteins eluted with 250 mm imidazole containing buffer. In every case, precursor protein was detec...

Ngày tải lên: 23/03/2014, 07:20

... clotrimazole, creatine kinase, creatine phosphokinase, daunorubicin, dideoxyforskolin, iso- butylmethylxanthine (IBMX), doxorubicin, estradiol 17- b-D-glucuronide, forskolin, glibenclamide, glutathione (reduced ... but vincristine itself had no effect even at 200 l M (Table 3). It is known that several cationic MRP1 substrates, including vincristine, require GSH for their transport and that v...

Ngày tải lên: 23/03/2014, 21:20

... reported in the present study, and obtained in living cells, confirm the finding obtained in reconsti- tuted proteoliposomes [11,12] and isolated membranes [29,30] indicating that Pgp and a bacterial multidrug ABC-transporter ... up into cells accumulate in the cytoplasmic leaflet prior to being released into the cytoplasm. In the latter case, Pgp functioning as a flippase will have t...

Ngày tải lên: 29/03/2014, 08:20

... the kinetics of anthracycline uptake and the resistance fac- tor in cancer cells expressing the multidrug resistance protein or the P-glycoprotein. Bochim Biophys Acta 1450, 374–384. 21 Fantini ... the resis- tance factor, kinetics of uptake, and kinetics of the P- glycoprotein-mediated efflux of doxorubicin, daunorubi- cin, 8-(S)-fluoroidarubicin, and idarubicin in multidrug- res...

Ngày tải lên: 30/03/2014, 09:20