Báo cáo khoa học: Do bacterial genotoxins contribute to chronic inflammation, genomic instability and tumor progression? pot

... contribute to chronic inflammation, genomic instability and tumor progression? Lina Guerra, Riccardo Guidi and Teresa Frisan Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, ... 239–248. Bacterial genotoxins and genomic instability L. Guerra et al. 4588 FEBS Journal 278 (2011) 4577–4588 ª 2011 The Authors Journal compilation ª 2011 FEB...

Ngày tải lên: 14/03/2014, 22:20

... actor (EGF), which bind to dedicated receptors. Upon EGF binding, its receptor (EGFR) dimerizes, leading to autophosphoryla- tion of tyrosine residues on the cytoplasmic domain of the receptor, ... gives rise to large signalling networks. In order to fully understand how such networks operate, it is necessary to integrate experimental d ata a nd to understand how (qualitatively)...

Ngày tải lên: 19/02/2014, 16:20

... parental and modified vectors con- taining control and Luc targeting sequences and the efficiency of down-regulation assessed (Fig. 3). Expres- sion of Luc artificial miRNA from the modified vec- tors ... artificial miRNA sequences into the targeting vectors. The terminal regions of the arms of the miR155 (A) and miR30 (B) vectors are shaded, and their stems designed to be replaced by...

Ngày tải lên: 07/03/2014, 11:20

... (2005) SH2-containing 5¢ inositol phosphatase SHIP2 regulates cytoskeleton organization and ligand-dependent downregulation of the epidermal growth factor receptor. J Biol Chem 280, 13129–13136. 18 ... FEBS 2521 Src homology 2 domain containing inositol 5-phospha- tase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylino- sitol 3,4,5-tris...

Ngày tải lên: 16/03/2014, 19:20

... (NaCl/P i ) and once with hypotonic buffer. The cells were resuspended in hypotonic buffer, incubatedfor10minonice,andbrokenby12strokesina Dounce homogenizer. The extracts were centrifuged at 4 °C and ... common to JCV, SV40 and PyV, different host factors in each case ultimately determine the restriction of virus propagation to a particular host. For SV40 and PyV these are, respe...

Ngày tải lên: 17/03/2014, 03:20

... makes use of semantic information to handle structural ambiguities. The questioning done by the syntactic analyzer to the semantic component a~ms to cut down the number of parse trees, but ... BCs, BCi and BCj, whose heads are Wi and Wj respectively. 2) semantic relation SR is compatible with the grammatical relation GR and with the set of features Fi and Fj associated...

Ngày tải lên: 18/03/2014, 02:20

... excitotoxicity induced by excess amounts of glutamate can contribute to motor neuron degeneration in ALS [4–6]. Decreased levels of aspartate aminotransferase can potentially contribute to excess ... [4]. Many hypotheses of how mutant SOD1 could cause neurodegeneration, including aberrant redox chemistry, mitochondrial damage, excitotoxicity, microglial activation and inflammation,...

Ngày tải lên: 23/03/2014, 04:21

... in a bacterial tyrosinase Michael Fairhead and Linda Tho ¨ ny-Meyer EMPA, Swiss Federal Laboratories for Materials Testing and Research, Laboratory for Biomaterials, St Gallen, Switzerland Introduction Tyrosinases ... Streptomyces type tyrosinases and processed eukaryotic tyrosinases and haemocyanins [10]. This motif can also be seen to be present in the V. spinosum tyrosinase (Fi...

Ngày tải lên: 06/03/2014, 11:20

... TÍNH TO N LIÊN KẾT BU LÔNG TRONG NÚT KHUNG NHÀ CÔNG NGHIỆP ThS. Nguyễn Thanh Hà, Khoa Xây dựng Dân dụng và Công nghiệp, Trường Đại học Xây dựng Vit Nam hin nay vic tớnh to n cu to liờn ... ct. Kt qu tớnh to n lm rừ hn u nhc im khi ỏp dng cỏc cỏch tớnh ny. LA CHN PHNG PHP BO DNG Bấ TễNG HIU QU TRONG IU KIN KH HU NểNG M TS. H Ngc Khoa, ThS. Nguyn Hựng Cng Khoa Xõy d...

Ngày tải lên: 07/03/2014, 03:20

... addition, it contributes to correct positioning of the substrate against the catalytic SerB1. GlnB23 was also shown to interact with the nucleo- phile and the general base, and contribute to the stabilization ... substrate is partially restored, and the protonated general base is properly oriented to give a proton to the leaving group nitrogen (Table 2). In the case of R = H...

Ngày tải lên: 16/03/2014, 01:20