Báo cáo khoa học: Deamidation of labile asparagine residues in the autoregulatory sequence of human phenylalanine hydroxylase potx

... Biochem. 270) Ó FEBS 2003 Deamidation of labile asparagine residues in the autoregulatory sequence of human phenylalanine hydroxylase Structural and functional implications Therese Solstad 1 , Raquel ... containing the regulatory and catalytic domains [15]. Fig. 2. Stereo picture of the three Asn residues in the N-terminal autoregulatory sequence of...

Ngày tải lên: 08/03/2014, 08:20

... stability for crystallins is essential in maintaining lens transparency [4]. Determining the mechanism of folding and assembly of these proteins is important for understanding how they can form stable ... concentrations. The d 2 -crystallin in lens was recruited during evolution from argininosuccinate lyase, an enzyme involved in arginine biosynthesis derived from the urea cyc...

Ngày tải lên: 08/03/2014, 08:20

... chain is brefeldin A-insensitive and is inhibited by the proteasome inhibitor clasto-lactacystin b-lactone, resulting in the accumulation of ricin A chains. These stabilized ricin A chains are partly deglycosylated ... pivotal role of the UPR is to maintain ER home- ostasis. Therefore, the presence of mutated proteins that are unable to fold into their native conformation in...

Ngày tải lên: 16/03/2014, 11:20

... promoting an increase in proopiomelanocortin and cocaine and amphetamine regulated transcript. Taken together, these findings provide a compelling argument for the role for malo- nyl-CoA in regulating ... to be explored further. Other areas of the brain have also been shown to regulate feeding via AMPK [35,36]. Of interest is the extensive use of fructose as a sweetener in t...

Ngày tải lên: 14/02/2014, 22:20

... investigated the metal-binding reactivity of the isolated a domain of human metallothionein isoform 1a, with specific emphasis on resolving the debate concerning the cooperative nature of the metal-binding ... the meta- llation mechanisms of the individual domains, in the hope, initially, of simplifying the interpretation of the metallation details of the...

Ngày tải lên: 19/02/2014, 00:20

... from the other bran- ches, which was indeed predicted. The other main group, obtained 97% of the time in 20 740 explored trees, contained the DIDO PHD sequences clustered with the PHF and the ... inhi- bitor of growth protein 3 (ING3) PHD, which is another domain involved in chromatin binding and clearly more divergent (e-value 0.019) from DIDO and the other sequences. A...

Ngày tải lên: 07/03/2014, 21:20

... com- plete loss of any of the three CCM proteins within endothelial cells lining the cavernous capillary cavities. These data were an important step towards the elucidation of the mechanisms of this ... towards the understanding of the mechanisms of this disorder. This minireview summarizes the advances in CCM molecu- lar genetics and the remaining gaps in this...

Ngày tải lên: 15/03/2014, 10:20

... whether the SLe x level of InR on insulin-responsive cells in diabetic patients was changed. This may reveal the role of the sugar chains on InR in the pathogenesis of diabetes. In summary, the ... higher than in the corresponding control cells cultured in the absence of insulin. The response to insulin stimulation was proportional to the expression of a1...

Ngày tải lên: 16/03/2014, 12:20

... cellular retinal-binding protein; CRBP, cellular retinol-binding protein; IRBP, interphotoreceptor retinoid-binding protein; RBP, retinol-binding protein. Note: The nucleotide sequence reported in this ... staining of the gel indicates that the fluorescing protein is one of the major components of soluble proteins in the crude extract. The surface of the fluorescing...

Ngày tải lên: 17/03/2014, 03:20

... Another essential feature of the lipoate residues within the 2-oxo acid dehydrogenase complexes arises from the ÔcrowdingÕ effect. Confinement of the complex-bound lipoate within the volume of the ... Rather, the advantage appears to depend on the ability of the lipoyl group to protrude from the inner core of the complex, indicative of the biological signi...

Ngày tải lên: 17/03/2014, 09:20