Báo cáo khoa học: The stop transfer sequence of the human UDPglucuronosyltransferase 1A determines localization to the endoplasmic reticulum by both static retention and retrieval mechanisms docx

... The stop transfer sequence of the human UDP- glucuronosyltransferase 1A determines localization to the endoplasmic reticulum by both static retention and retrieval mechanisms Lydia ... fusion of UGT1A stop transfer sequence (TMD ⁄ CT) with the ectodomain of the plasma membrane CD4 reporter protein. We showed that the stop transfer...

Ngày tải lên: 07/03/2014, 16:20

... surface. They are found at the outermost ends of the sugar chain of animal glycoconjugate. They act as an important component of the ligands recognized by the lectins. Recognition can be affected by ... until the A 280 of the effluent was < 0.002. The column was further washed with LSB at 4 °C until the A 280 of the effluent was < 0.002, and it was then t...

Ngày tải lên: 21/02/2014, 00:20

... 3¢ end of the DBD) and SmRXR1 (Glu251 to Asn376) (containing 20 amino acids at 5¢ end of the DBD, the DBD and 40 amino acids at the 3¢ end of the DBD) were tested. Both SmNR1 (Ile247 to Ser372) and SmRXR1 ... regula- tion of a number of genes [7–10]. Study of SmRXR partners will add to our knowledge of nuclear receptor gene regulation in schistosomes and...

Ngày tải lên: 07/03/2014, 11:20

... starvation-induced spherulation of plasmodia and that then comprise  10% of the total mRNA [16]. Among them, spheru- Fig. 2. Structural alignment of amino acid sequence by motifs, of spherulin 3b with spherulin 3a and other ... ([6] and references therein), suggesting the presence of detect- able amounts of PMLA synthetase-specific mRNA. The absence of PMLA and...

Ngày tải lên: 07/03/2014, 12:20

... the conversion of long-chain fatty acyl-CoAs to acylcarni- tines in the presence of l-carnitine. This is the first step in the transport of long-chain fatty acids from the cytoplasm to the mitochondrial ... or human CPT1B enzymes determines the overall malonyl-CoA sensitivity of these enzymes. Thus, the N-terminal 50 amino acids of the human sequence inc...

Ngày tải lên: 16/03/2014, 04:20

... Department of Microbiology and Immunology and the College of Medicine, by Public Health Service grant CA101931 (to D.J.M.) from the National Institutes of Health, and the Australian Research Council (to ... M. (1978) Oxygen and nitrate in utilization by Bacillus licheniformis of the arginase and arginine deiminase routes of arginine catabolism and other fac...

Ngày tải lên: 16/03/2014, 16:20

... cerevisiae;andSp,Schizosaccharomyces pombe. Only the t hree common sequence motifs are reported. The numbers in dicate the distances to the N term inus of each protein and the sizes of the gaps between ... regula- tive) of the mechanisms generating these species. Moreover, cN-II presents both phosphatase and phosphotransferase activities. Even though the phys...

Ngày tải lên: 16/03/2014, 18:20

... carbohydrates associated with the a-chain of either species (data not shown). Hypothetical model for the formation of the deer Hp tetramer The ability of the deer Hp to refold and reassemble into its tetrameric ... similar to that of human, with 142 (a2) and 245 (b) residues (Fig. 5A,B). A tandem repeat of the deer a-chain was observed (discussed below). Amino a...

Ngày tải lên: 23/03/2014, 07:20

... substrate. The Val349Ile mutant of the 15S-COX formed 65% PGF 2a and 35% of the 15R-epimer of PGF 2a . In the case of the 15R-COX, the Ile349Val mutation caused a more pronounced effect on the stereochemistry ... The correct orientation of t he cDNA insert in the v ector was confirmed by digestion with XbaI and the presence of mutations by digestion with...

Ngày tải lên: 23/03/2014, 12:20

... the K d for the initial bind- ing of minifiber. The fluorescence emission of the TMR was assumed to be independent of the binding of the minifiber to the penton base, because it is attached at the ... (minifiber), and [Lig tot ] is the total con- centration of the ligand. At any total concentration of lig- and, the anisotropy depends on the total concent...

Ngày tải lên: 19/02/2014, 06:20