Báo cáo khoa học: Androgen receptor function is modulated by the tissue-specific AR45 variant ppt

... 20702–20710. Androgen receptor variant form I. Ahrens-Fath et al. 84 FEBS Journal 272 (2005) 74–84 ª 2004 FEBS Androgen receptor function is modulated by the tissue-specific AR45 variant Isabelle ... of these effects [18]. Another possibility arises from the existence of variant forms of steroid receptors. The estrogen receptor (ER) probably belongs to the m...

Ngày tải lên: 07/03/2014, 16:20

... proteins within the cell. We found this translocation to be dependent on the final amino acids of the receptor protein. Similar to the other PDZ domain interactions that have been shown to be abolished by ... expression system. We hypothesized that, by deleting the components of the PDZ binding motif, we could disrupt MUPP1 translocation. Truncation of the receptor from...

Ngày tải lên: 18/02/2014, 13:20

... activation. In addition, the activity of LRH-1 is modulated by post-translational modification. The transcriptional activity of LRH-1 is stimulated by phosphorylation following 4b-phorbol 12-myristate 13-acetate ... bodies. It is well known that the control of ovarian function and steroid production by gonadotrophins is mainly through the activation of the cAMP ⁄ pr...

Ngày tải lên: 23/03/2014, 06:20

... confirming the impor- tance of ribosome function in erythropoiesis. Further support for this hypothesis can be obtained by the analysis of other human pathologies, such as dyskera- tosis, cartilage-hair ... cannot be ruled out, the most likely hypothesis is that erythropoiesis is the human developmental pro- cess that is most sensitive to ribosomal defects. Consis- tent with...

Ngày tải lên: 07/03/2014, 01:20

... translocation; this latter function appears to be the only one that is common to all bacteria. In Yer- sinia, the increased synthesis of LcrV triggered by the activation of the system leads to the titration ... pathogen-specific, and their different characteristics and cellular fates influence the distinct infectious phenotypes of the source microor- ganism [2]. In this revi...

Ngày tải lên: 14/02/2014, 22:20

... affected by the same siRNA (Fig. 3B, right). To further test whether the inhibition of Erk activation was caused by the reduction in Shc proteins, rescue experiments were performed using the siRNA-mediated ... cell–cell adhesion and induce signaling despite the fact that they interact with E- cadherin in different manners. Therefore, it is most likely that it is the disrup...

Ngày tải lên: 19/02/2014, 05:20

... land. The asking price is 1 million dollar and the annual taxes are 8000 dollars. The house is located in the Byram Hills School District. E2 S4 This is a 1 million dollar 3 bedroom house. This is ... This is a 1 million dollar house. This is a 3 bedroom house. This is a 2 bathroom house. This house has 2000 square feet. This house has 2 acres of land. This house has 2 c...

Ngày tải lên: 20/02/2014, 15:20

... was included to inhibit the feedback proteolysis of prothrombin by the generated thrombin). The reaction was stopped by the addition of an equal volume of acetic acid, and the resulting mixture ... pro- thrombin by the complex (prothrombinase complex) is >10 5 times faster than activation by free Xa [15]. Therefore, physiological coagulation is eventually cata- lyze...

Ngày tải lên: 07/03/2014, 00:20

... 3-hydroxymyristoyl CoA substrate is bio- synthesized by the primary metabolism. Recently, it was reported that the acyl CoA substrate is transferred to the initiation module SrfA-A1. This transfer is stimulated ... mechanism for the lipidation of daptomycin by DptE and DptF. Decanoic acid is activated by the putative adenylating enzyme DptE under ATP con- sumption. Th...

Ngày tải lên: 07/03/2014, 04:20

... to maximize the quality control of proteins in the secretory pathway. It is not known whether the vacuolar function is enhanced by the UPR in plants. Other UPR in plants The UPR is composed of ... con- tain the enormous number of proteins that are actively synthesized there [192–194]. Therefore, the UPR that is unique to plants is expected to function widely, alt...

Ngày tải lên: 16/03/2014, 11:20