Báo cáo khoa học: Changes in acetylcholine receptor function induce shifts in muscle fiber type composition docx

... 1 fibers (dark stain), type 2A fibers (light stain), and type 2B ⁄ 2D fibers (intermediate stain). (B) ATPase staining at pH 9.4 identifies type 1 fibers (light stain), and type 2 fibers (dark stain). ... identical muscle fibers in serial cross- sections. (i) Type 1 muscle fiber. (a) Type 2A muscle fiber. (b) Type 2B ⁄ 2D muscle fiber. Scale bar in (D) is 100 lm. (A)...

Ngày tải lên: 07/03/2014, 05:20

... ligand-binding domain; a transmembrane domain; an intracellular tyrosine kinase domain; and a C-terminal regulatory domain [2]. The extracellular domain is subdivided further into four domains. ... EGFR (including EGF, transforming growth factor-a, amphi- regulin and epigen); (b) those that bind to EGFR and ERBB4 (including betacellulin, heparin-binding EGF and epiregulin); and (c) neuregulin...

Ngày tải lên: 16/02/2014, 09:20

... compete with ATP for binding to the tyrosine kinase pocket of the receptor, thereby inhibiting receptor tyrosine kinase activity and EGFR signaling pathways (Fig. 1). Early clinical studies showed ... extracellular domain of the receptor, thereby inhibiting ligand-dependent EGFR signal transduction; and small- molecule tyrosine kinase inhibitors, such as gefitinib and erlotinib, which tar...

Ngày tải lên: 16/02/2014, 09:20

... major interaction site for the adenine moiety. In b1, an arginine residue (Ile417 in rPDE2) binds to N1 and a threonine (Ser419 in rPDE2) inter- acts with N7 and the N 6 amino group. The inter- actions ... cGMP binding [13], and, in PDE6, both of the amino acids corresponding to Phe433 ⁄ Asp434 in rPDE2A are required for cGMP binding [14]. Our initial mutations in cyaB1 GAF B also...

Ngày tải lên: 19/02/2014, 02:20

... FUÆlgprotein )1 Æh )1 ). In parallel with this decrease in activity, oxidized proteins accumulated in the matrix upon aging while the CML-modified protein content assessed by ELISA significantly increased ... been found in several mammals including human tissues and cell lines [24–26]. It is responsible for the degradation of abnormal proteins and certain short-lived specific proteins [2...

Ngày tải lên: 20/02/2014, 11:20

... protein family that resides in an inactive state in the cytoplasm of normal cells. Following an apoptotic stimulus, BAX undergoes conformational changes [1–4], becoming a mediator of the intrinsic ... blot. Protein loading was determined by using anti-ANT polyclonal IgG. (C) Cytochrome c content in mitochondria (M) and in supernatants (SS) recovered after rBAX incubation. Proteins...

Ngày tải lên: 07/03/2014, 05:20

... and the incidence of crisis recognition in hospitals. Their review of over 2000 events revealed an increase in events at certain times of the day, notably near nursing handoffs and physician rounding. ... there are no randomized clinical trials showing benefit from introduction of METs, many single center reports [2-4] support the notion that timely intervention may interrupt crisis event...

Ngày tải lên: 25/10/2012, 10:45

... K, Kuroiwa Y et al. (2008) RNA-binding protein TLS is a major nuclear aggregate-interacting protein in hunting- tin exon 1 with expanded polyglutamine-expressing cells. J Biol Chem 283, 6489–6500. 25 ... absence of Lewy bodies in MPTP-induced parkinsonism in humans. However, eosinophilic intraneuronal inclusions have been seen in the same region as Lewy bodies in squirrel monkeys in...

Ngày tải lên: 14/02/2014, 19:20

... having sufficient power are therefore extremely important in minimizing the in uence of confounding factors arising from inherent problems associated with breeding APP transgenic mice and maintaining ... time-consuming and greatly in uenced by individual handlers. IntelliCages are automated learning cages where animals carrying transponders are housed in groups and trained in learning...

Ngày tải lên: 16/02/2014, 09:20

... protein utilizing the principle of protein–dye binding. Anal Biochem 2, 248–254. 38 Bauer R & Rupe CO (1971) Use of syringaldazine in a photometric method for estimating ‘free’ chlorine in water. ... variations in identity (for example ranging from 38–86% in Coprinopsis cine- rea [27]). This natural diversity within in a single organism can be used for protein engineering purpos...

Ngày tải lên: 18/02/2014, 06:20