Báo cáo khoa học: Changes in acetylcholine receptor function induce shifts in muscle fiber type composition docx
Báo cáo khoa học: Changes in acetylcholine receptor function induce shifts in muscle fiber type composition docx
... 1 fibers (dark stain),
type 2A fibers (light stain), and type 2B ⁄ 2D fibers (intermediate
stain). (B) ATPase staining at pH 9.4 identifies type 1 fibers (light
stain), and type 2 fibers (dark stain). ... identical muscle fibers in serial cross-
sections. (i) Type 1 muscle fiber. (a) Type 2A muscle fiber.
(b) Type 2B ⁄ 2D muscle fiber. Scale bar in (D) is 100 lm. (A)...
Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer ppt
... ligand-binding domain; a transmembrane
domain; an intracellular tyrosine kinase domain; and a
C-terminal regulatory domain [2]. The extracellular
domain is subdivided further into four domains. ... EGFR
(including EGF, transforming growth factor-a, amphi-
regulin and epigen); (b) those that bind to EGFR and
ERBB4 (including betacellulin, heparin-binding EGF
and epiregulin); and (c) neuregulin...
Tài liệu Báo cáo khoa học: Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy doc
... compete with ATP for binding to
the tyrosine kinase pocket of the receptor, thereby
inhibiting receptor tyrosine kinase activity and EGFR
signaling pathways (Fig. 1). Early clinical studies
showed ... extracellular domain of the receptor,
thereby inhibiting ligand-dependent EGFR signal transduction; and small-
molecule tyrosine kinase inhibitors, such as gefitinib and erlotinib, which
tar...
Tài liệu Báo cáo khoa học: Changes in purine specificity in tandem GAF chimeras from cyanobacterial cyaB1 adenylate cyclase and rat phosphodiesterase 2 pptx
... major interaction site for the adenine
moiety. In b1, an arginine residue (Ile417 in rPDE2)
binds to N1 and a threonine (Ser419 in rPDE2) inter-
acts with N7 and the N
6
amino group. The inter-
actions ... cGMP binding [13], and, in PDE6, both of the
amino acids corresponding to Phe433 ⁄ Asp434 in
rPDE2A are required for cGMP binding [14].
Our initial mutations in cyaB1 GAF B also...
Tài liệu Báo cáo khoa học: Changes in rat liver mitochondria with aging Lon protease-like activity and N e-carboxymethyllysine accumulation in the matrix doc
... FUÆlgprotein
)1
Æh
)1
). In parallel with this decrease in
activity, oxidized proteins accumulated in the matrix upon
aging while the CML-modified protein content assessed
by ELISA significantly increased ... been found in several mammals
including human tissues and cell lines [24–26]. It is
responsible for the degradation of abnormal proteins and
certain short-lived specific proteins [2...
Báo cáo khoa học: Changes in specific lipids regulate BAX-induced mitochondrial permeability transition pptx
... protein
family that resides in an inactive state in the cytoplasm
of normal cells. Following an apoptotic stimulus, BAX
undergoes conformational changes [1–4], becoming a
mediator of the intrinsic ... blot. Protein loading was
determined by using anti-ANT polyclonal IgG. (C) Cytochrome c content in mitochondria (M) and in supernatants (SS) recovered after rBAX
incubation. Proteins...
Báo cáo khoa học: "Medical emergency teams: deciphering clues to crises in hospitals"
... and
the incidence of crisis recognition in hospitals. Their review of
over 2000 events revealed an increase in events at certain
times of the day, notably near nursing handoffs and physician
rounding. ... there are no
randomized clinical trials showing benefit from introduction of
METs, many single center reports [2-4] support the notion
that timely intervention may interrupt crisis event...
Tài liệu Báo cáo khoa học: Modulation of a-synuclein aggregation by dopamine in the presence of MPTP and its metabolite pptx
... K,
Kuroiwa Y et al. (2008) RNA-binding protein TLS is a
major nuclear aggregate-interacting protein in hunting-
tin exon 1 with expanded polyglutamine-expressing
cells. J Biol Chem 283, 6489–6500.
25 ... absence of Lewy bodies
in MPTP-induced parkinsonism in humans. However,
eosinophilic intraneuronal inclusions have been seen in
the same region as Lewy bodies in squirrel monkeys
in...
Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx
... having sufficient power are therefore
extremely important in minimizing the in uence of
confounding factors arising from inherent problems
associated with breeding APP transgenic mice and
maintaining ... time-consuming and greatly
in uenced by individual handlers. IntelliCages are
automated learning cages where animals carrying
transponders are housed in groups and trained in
learning...
Tài liệu Báo cáo khoa học: Plasticity of laccase generated by homeologous recombination in yeast docx
... protein
utilizing the principle of protein–dye binding. Anal
Biochem 2, 248–254.
38 Bauer R & Rupe CO (1971) Use of syringaldazine in a
photometric method for estimating ‘free’ chlorine in
water. ... variations in identity
(for example ranging from 38–86% in Coprinopsis cine-
rea [27]). This natural diversity within in a single
organism can be used for protein engineering purpos...