Báo cáo khoa học: Role of DptE and DptF in the lipidation reaction of daptomycin ppt

... proteins (ACPs) [14,15]. The genes dptE and dptF are localized immediately upstream of the NRPSs of A21987C. The resulting proteins DptE and DptF were predicted to be involved in the lipidation reaction based ... the initiation module of dapto- mycin. That DptE and DptF are involved in the lipidation process of daptomycin was first shown by Mia...

Ngày tải lên: 07/03/2014, 04:20

... promoting an increase in proopiomelanocortin and cocaine and amphetamine regulated transcript. Taken together, these findings provide a compelling argument for the role for malo- nyl-CoA in regulating ... nutrient sensing in the brain and is an example of an enzyme that can sense and respond to the nutritional environment. The major challenge to understanding the r...

Ngày tải lên: 14/02/2014, 22:20

... meanings). 2. the meaning of the rules (rule meanings). In Montague Grammar these meanings are ex- pressed in intensional logic. In the Rosetta system the meanings of rules and basic expressions ... for the compositional and the analytical definition of a language. This is proved by the formal definitions in subsection 6.2. The third problem concerned...

Ngày tải lên: 22/02/2014, 10:20

... oligomers and interact with other proteins. The improvement of microscopic techniques will promote the understanding of the dynamics and toxicity of mis- folded proteins in living cells in the near ... examination of the polyubiquitination of mutant SOD1 using FRET may be useful for inves- tigating the details of the role of the ubiquitin–protea- some s...

Ngày tải lên: 06/03/2014, 09:22

... stability for crystallins is essential in maintaining lens transparency [4]. Determining the mechanism of folding and assembly of these proteins is important for understanding how they can form stable ... concentrations. The d 2 -crystallin in lens was recruited during evolution from argininosuccinate lyase, an enzyme involved in arginine biosynthesis derived from the urea c...

Ngày tải lên: 08/03/2014, 08:20

... chain is brefeldin A-insensitive and is inhibited by the proteasome inhibitor clasto-lactacystin b-lactone, resulting in the accumulation of ricin A chains. These stabilized ricin A chains are partly deglycosylated ... pivotal role of the UPR is to maintain ER home- ostasis. Therefore, the presence of mutated proteins that are unable to fold into their native conformation...

Ngày tải lên: 16/03/2014, 11:20

... the context of DNA binding and chromatin regulation. These homologues include members of the CpG binding protein (CGBP) family of proteins that bind DNA at unmethylated CpG islands [7], which are ... inhi- bitor of growth protein 3 (ING3) PHD, which is another domain involved in chromatin binding and clearly more divergent (e-value 0.019) from DIDO and the other sequence...

Ngày tải lên: 07/03/2014, 21:20

... binding of TM by thrombin. Binding of the carboxy-terminal part of the reactive center loop of PAI-1 in the small cleft formed by the 60-loop and VR1 loop can be envisioned. The kinetics of the ... PAI-1/VN complexes, suggests the involvement of the chondroitin sulphate of rl-TM in the binding of PAI-1/VN. Indeed, both in the absence and presence...

Ngày tải lên: 23/03/2014, 17:21

... consisted of the first two functional domains, namely the phenylalanine- specific A domain and the PCP domain. The terminal E domain was excised (the exact amino acid composi- tion of the investigated ... lead to the formation of the amino acyl thioester on the Ppant of the PCP domain and prime the enzyme for the next step in the reaction sequence. There...

Ngày tải lên: 29/03/2014, 08:20

... regulator of MAPK cascades, mitogen-activated protein kinase kinase kinase 7 interacting protein 2 (TAK 1 binding protein 2 ¼ TAB 2), as an IEG during hyperosmotic stress in tilapia gill epithelium ... gene is transiently and very rapidly (within 2 h) induced by hyperosmotic stress, indicating a role of this mitogen- activated protein kinase kinase kinase 7 interacting protein for o...

Ngày tải lên: 18/02/2014, 16:20