... carcinomas; IAP, inhibitor of apoptosis protein; JNK, c-Jun NH2-terminal kinase; KIP, kinase inhibitor proteins; MEK,MAPK ⁄ ERK kinase; MKK, MAPK kinase; MKP-1, mitogen-activated protein kinase ... JapanIntroductionThe epidermal growth factor receptor (EGFR) is com-posed of an extracellular ligand-binding domain, atransmembrane domain and an intracellular tyrosinekinase domain. The binding ... CIP1is involved in gefitinib-induced growthinhibition in HNSCC [58]. Another group of cell-cycleregulatory molecules – those of the INK4 family – hasalso been implicated in gefitinib-induced inhibition...