Tài liệu Báo cáo khoa học: "Names and Similarities on the Web: Fact Extraction in the Fast Lane" ppt

... The main processing stages are the acquisition of contextual extraction patterns given the seed facts, acquisition of candidate facts given the extraction patterns, scoring and ranking of the patterns, ... extraction patterns Validation of candidate facts Scored extraction patternsScored candidate facts Scoring and ranking Validated candidate facts Seed facts Occurrences...

Ngày tải lên: 20/02/2014, 12:20

... contains canonical phosphate linkers. Then, we assessed two mononucleo- sides and two dinucleosides containing an N-acylsulf- onamide linker [R–S(O 2 )–NH–C(O)–R¢], which has three nonbridging ... groups, mimicking the backbone of RNA but without the torsional constraint imposed by a ribose ring. To reveal a contribution from additional nonbridging oxygen atoms on enzyme inhibition, w...

Ngày tải lên: 14/02/2014, 22:20

... that connect it to the electron-donating (FNR) and electron- accepting (NOSoxy) components within the NOS dimer. The CaM-binding site (gray box) in the H2 hinge enables CaM to in uence the movements. ... electron acceptor (receiving electrons from FAD) and an electron donor, and is thought to undergo large conformational movements and engage in two distinct protein–prot...

Ngày tải lên: 18/02/2014, 11:20

... Significantly, warfarin administration at subclini- cal doses inhibits these increases, further supporting the involvement of vitamin K (and Gas6) in the dis- ease aetiology. In addition, Gas6 knockout ... revealed, one major and one minor, with only the minor one being conserved within the Axl subfamily. No direct Axl–Axl or Gas6–Gas6 contacts were appar- ent in the complex...

Ngày tải lên: 19/02/2014, 05:20

... contains a few inserted b-strands (1a in Fig. 2), and one large insert of 15 amino acids is present before the first b-sheet of coil 3, which is on the edge of the pronounced sub- strate-binding ... activity on oligosaccharides with an increasing degree of polymerization. The highest activity was found on the pentamer (1000 UÆmg )1 ). In addition, the affinity increased...

Ngày tải lên: 20/02/2014, 03:20

... chain corresponding to the catalytic domain (C domain); and the B chain corresponding to the translocation domain (T domain) and the receptor-binding domain. The C and T domains remain covalently linked ... leading to insertion of the toxin in the membrane. The C domain is then translocated across the endosomal membrane into the cytosol. The C domain ADP-ribosyla...

Ngày tải lên: 16/02/2014, 09:20

... to strongly polarize the carbonyl of the substrate. The carbonyl carbon becomes very electrophilic and as the bond between the serine c-oxygen and the carbonyl carbon forms, the pK a of the Oc ... distortion results from the strong polarization of the C–O bond by the dipoles of the oxyanion hole in conjunction with the in uence of a close nucleophile like the...

Ngày tải lên: 20/02/2014, 23:20

... Choline, glycine betaine biosynthesis Nicotiana tabacum Import of choline into the chloroplast is a major but not the only important constraint on glycine betaine synthesis. The regulation is ... encountered in publica- tions in the field. Introduction One of the fastest growing fields in the life sciences is systems biology. PubMed lists more than 3000 articles which, in...

Ngày tải lên: 14/02/2014, 14:20

... transcribed regions of active genes in human T cells [124]. In a study in yeast, mutations were introduced alone or in combination in lysines 5, 8, 12 and 16 in the gene for histone H4 [125]. Of these, the only ... modification and are maintained in a constitutively active state by CXXC domain proteins that bind to non-methylated CG sequences. These proteins include MLL1...

Ngày tải lên: 14/02/2014, 18:20

... in turn, the induced miRNAs regulate these pathways by repressing the expression of components of the signal- ing pathways and, in some cases, components of other signaling pathways, thus forming ... lipopolysaccharide via the activation of the receptor TLR4 and also is involved in the feedback control of nuclear factor kappa B (NF-jB)-dependent responses by inhibiting t...

Ngày tải lên: 14/02/2014, 19:20