Tài liệu Báo cáo khoa học: Covalent binding to glutathione of the DNA-alkylating antitumor agent, S23906-1 doc

... reduces the cytotoxic potential of S23906-1 towards KB-3-1 epidermoid carcinoma cells. The GSH-induced threefold reduction of the cytotoxicity of S23906-1 is attributed to the reduced formation of ... and glutathione to rats and cancer patients [39]. The primary objective of the present study was to investigate further the reactivity of S23906-1 towards...

Ngày tải lên: 20/02/2014, 11:20

... related to essential functions, and topologi- cal features retain functionality and phylogeny. How- ever, the nature of the connections between these factors needs to be understood at the level of the ... understood as the architecture of the regulatory backbone. It pro- vides a topological view of the interaction patterns among the elements responsible for gene ex...

Ngày tải lên: 19/02/2014, 07:20

... 2). The intensity of the circular dichroic band decreases upon addition of calcium ions because cal- cium displaces the dye bound to calcium -binding sites of the protein. Other proteins of this ... Isothermal titration calorimetry: (A) calcium -binding isotherm of bB2-crystallin. (B) Terbium binding isotherm of bA3-crystallin. The best fit to four-site sequential...

Ngày tải lên: 18/02/2014, 16:20

... compounds of substrates, products and regulators of other enzymes in the human nucleotide metabolism (Table S1). The library can then be seen to constitute the specific metabolome of the nucleotide metabolism, ... important regulatory role, although the molecular basis for this activity remains to be eluci- dated. The elucidation of the structure of PRTFDC1 and the...

Ngày tải lên: 15/02/2014, 01:20

... relationship between the expression of these transcription factors and the cytokine genes known to be produced by dif- ferent T-cell subtypes in mammals. These transcription factors, together with many of the ... whether these cytokines are produced by CD4 + CD25 + Foxp3 + T reg or whether they induce the production of these cytokines from another population of cells [20]....

Ngày tải lên: 16/02/2014, 09:20

... link between the GTPase -binding capacity of YpkA and OTUB1-mediated increase in susceptibility to infection (Fig. 6). The binding of small GTPases has been reported to be independent of the kinase ... on the catalytic activity of OTUB1 and its ability to stabilize the active form of RhoA prior to invasion. YpkA and OTUB1 modulate the stability of RhoA in op...

Ngày tải lên: 16/02/2014, 15:20

... found in the 5¢-region of approximately 60% of genes, near to their promoters [4,5]. The cytosine base is modified at the 5-carbon position of the pyrimidine ring by the covalent addi- tion of a methyl ... linker histone variants Location and structure of the linker histones Historically, the location of the globular domain of the linker histone has been a m...

Ngày tải lên: 18/02/2014, 08:20

... functions. The gene encoding the cyclin-depen- dent kinase inhibitor p21 is a target gene of SREBP [20]. This finding suggests that the regulation of lipid synthesis is linked to the regulation of cell ... involved in the regulation of genes participating in cholesterol biosynthesis and low-density lipoprotein receptor synthesis [1,2]. They are now estab- lished as global r...

Ngày tải lên: 18/02/2014, 13:20

... at pH 7.4. The CD spectra of IFP–V13 are similar to those of IFP– F13 under the same conditions. The insets to the panels display the results of the secondary s tructure analysis with the VARSELEC program. 4728 ... The bottom panel displays the result of deconvolution of the IR absorption spectrum of the peptide f or analysis of the sec ondary struc t...

Ngày tải lên: 19/02/2014, 16:20

... suggest- ing that the origin of these forms dates back to before the occurrence of vertebrates, i.e. more than 500 mya. This dates the differentiation of the MAPEG forms back to the late Cambrian ... and then the reformatted BamHI-EcoRI fragment was subcloned into BamHI and EcoRI sites of the pYeDP60 vector. The nucleotide sequence of the cDNA was determined wi...

Ngày tải lên: 19/02/2014, 17:20