Tài liệu Báo cáo khoa học: Different modes of dipeptidyl pep

Tài liệu Báo cáo khoa học: Different modes of dipeptidyl peptidase IV (CD26) inhibition by oligopeptides derived from the N-terminus of HIV-1 Tat indicate at least two inhibitor binding sites doc

... 270) Ó FEBS 2003 Different modes of dipeptidyl peptidase IV (CD26) inhibition by oligopeptides derived from the N-terminus of HIV-1 Tat indicate at least two inhibitor binding sites Susan Lorey 1 , ... of Tat( 1–9) with this model of DP IV including the substrate Ala-Pro-pNA bound to the active site with Ala at the S1 and Pro a...

Ngày tải lên : 20/02/2014, 11:20

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Tài liệu Báo cáo khoa học: "Different Structures for Evaluating Answers to Complex Questions: Pyramids Won’t Topple, and Neither Will Human Assessors" docx

... assessor a p . The recall of X is greater than zero, since X contains the response r that matches the nugget v that was marked as vital by a p (from (2), (1), and the def. of recall). The precision ... Pearson’s correlation of F-scores, by ques- tion and by run. are highly correlated, even at the level of individ- ual questions. Table 1 provides a summary of...

Ngày tải lên : 20/02/2014, 12:20

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Tài liệu Báo cáo khoa học: Elementary modes analysis of photosynthate metabolism in the chloroplast stroma ppt

... triose phosphate export from starch degradation in the absence of ATP regenerating light reactions; (b) the possible pathways made available from the combination of the enzymes of the oxidative pentose phosphate ... the oxidative reactions of the oxidative pentose phosphate pathway would rapidly exhaust their supply of cosubstrate, NADP. The nature of such a li...

Ngày tải lên : 20/02/2014, 23:20

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Tài liệu Báo cáo khoa học: Regulatory modes of rod outer segment membrane guanylate cyclase differ in catalytic efﬁciency and Ca2+-sensitivity ppt

... GCAP-2. The results further indicate the concerted operation of two ÔGCAP modes that would extend the dynamic range of cyclase regulation within the physiological range of free cytoplasmic Ca 2+ in ... coefﬁcient n from a ﬁt of the direct plot. Values of V max and K m were then determined from a plot of 1/V (reciprocal of guanylate cyclase activity) vs. 1/[S]...

Ngày tải lên : 21/02/2014, 00:20

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Tài liệu Báo cáo khoa học: Different mechanisms for cellular internalization of the HIV-1 Tat-derived cell penetrating peptide and recombinant proteins fused to Tat docx

... s under evaluation. Comparative FACS analysis of the internalization of the full-length Tat protein construct and the Tat CPP Differences in the mechanisms of internalization between the Tat peptide ... such treatment abolished the internalization of the GFP-fused Tat protein but did not alter the uptake of the Tat CPP. These biochemical evidences con®rme...

Ngày tải lên : 21/02/2014, 03:20

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Tài liệu Báo cáo khoa học: Mitochondrial chaperone tumour necrosis factor receptor-associated protein 1 protects cardiomyocytes from hypoxic injury by regulating mitochondrial permeability transition pore opening docx

... dissipate, pre- venting ATP generation by oxidative phosphorylation. Ultimately, these changes lead to cell death through the activation of phospholipases, nucleases and prote- ases [8]. Indeed, the ... intercellular domain of the type 1 tumour necrosis factor receptor [17]. On the basis of the sequence of the homologue, TRAP1 was identiﬁed as a member of the HSP90 f...

Ngày tải lên : 16/02/2014, 14:20

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Tài liệu Báo cáo khoa học: Is ATP binding responsible for initiating drug translocation by the multidrug transporter ABCG2? docx

... and vanadate generate an ADP-vanadate struc- ture mimicking the transition state for the hydrolysis of the c-phosphate of ATP [30]. Figure 5 demon- strates the effect of pre-incubation of ABCG2 R482G - containing ... reorientation, although the binding data cannot unequivocally inform on the orientation of the sites, only their afﬁnity for interaction with drugs....

Ngày tải lên : 18/02/2014, 18:20

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Tài liệu Báo cáo khoa học: Hu-K4 is a ubiquitously expressed type 2 transmembrane protein associated with the endoplasmic reticulum ppt

... site, the stop codon and the putative start codons ATG 1 and ATG 4 are indicated. The size of exons 1–5 is drawn in scale. (B) Alternative splicing of the 5¢-UTR. The splice variants, the number of nucleotides ... Putative start codons of Hu-K4. Comparison of the optimal translational start site given by Kozak [12] and the putative start codons in the Hu-K4 mRN...

Ngày tải lên : 19/02/2014, 17:20

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Tài liệu Báo cáo khoa học: A second novel dye-linked L-proline dehydrogenase complex is present in the hyperthermophilic archaeon Pyrococcus horikoshii OT-3 pptx

... 2-times that of the native enzyme. The purified PDH1 showed the same mobility as the native enzyme on native-PAGE, and the N-terminal amino-acid sequences of the a1 and b1 subunits of the recombinant ... heat treatment and two successive column chro- matographies:  50 mg of the purified enzyme was obtained from 2 L of E. coli culture, and the specific activity o...

Ngày tải lên : 20/02/2014, 01:20

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Tài liệu Báo cáo khoa học: "Improving Automatic Speech Recognition for Lectures through Transformation-based Rules Learned from Minimal Data" ppt

... task that com- bined active learning with acoustic model adaptation. They reduced the WER from 15% to 3% with 70 syllables of acoustic adaptation, relative to a baseline that reduced the WER ... on their dic- tation corpus (9.6%), and an RER over three times greater than that of our reimplementation of their heuristics on our lecture data (3.6%). This is on top of the averag...

Ngày tải lên : 20/02/2014, 07:20

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