Tài liệu Báo cáo khoa học: Open questions in ferredoxin-NADP+ reductase catalytic mechanism ppt

... NADP(H) binding domain in pink, and the FAD prosthetic group in yellow. (B) Detailed view of the isoalloxazine ring system in FNR, displaying relevant interactions with active site amino acid ... The flavoprotein molecule is made up of two structural domains, each containing approximately 150 amino acids (Fig. 1A). The carboxyl terminal region includes most of the residues involved in...

Ngày tải lên: 20/02/2014, 11:20

... may coin- cide in place, as in the question '~here are we now?". (b) The conversants ~ay be contained in the target, as in the question "Where is Israel?" when Posed in Jerus- ... parti- cipants in the conversation. Several loci in the data are indicative of this last pattern. First none of the Americans indicated that the Empire State Building was &quo...

Ngày tải lên: 21/02/2014, 20:20

... carcinomas; IAP, inhibitor of apoptosis protein; JNK, c-Jun NH 2 -terminal kinase; KIP, kinase inhibitor proteins; MEK, MAPK ⁄ ERK kinase; MKK, MAPK kinase; MKP-1, mitogen-activated protein kinase ... Japan Introduction The epidermal growth factor receptor (EGFR) is com- posed of an extracellular ligand-binding domain, a transmembrane domain and an intracellular tyrosine kinase domain. The bi...

Ngày tải lên: 16/02/2014, 09:20

... protein tyrosine kinases. These kinas- es result in the increased tyrosine phosphorylation of multiple macrophage proteins and the activation of phospholipase D [82]. Activation of protein tyrosine kinases ... mutation in the GTP-binding domain sup- presses temperature-sensitive chromosome partitioning mutations, indicating that Era is a cell-cycle check- point regulator [89,90]. Interest...

Ngày tải lên: 16/02/2014, 15:20

... (2008) Mapping alpha-helical induced folding within the intrinsically dis- ordered C-terminal domain of the measles virus nucleo- protein by site-directed spin-labeling EPR spectroscopy. Proteins 73, ... B, Finet S & Longhi S (2005) The intrinsically disordered C-terminal domain of the measles virus nucleoprotein interacts with the C-terminal domain of the phosphoprotein via two distinct...

Ngày tải lên: 18/02/2014, 04:20

... are linked to accessory proteins (e.g. zonula occludens proteins and cingulin), forging a connection to the actin cytoskeletons of endothelial cells [8]. Occlu- din is an  65 kDa phosphoprotein ... Claudins are  22 kDa phosphoproteins that are thought to help maintain high transendothelial electrical resistance. Three types of claudins (claudin1 ⁄ 3, claudin5 and claudin12) are found in ....

Ngày tải lên: 18/02/2014, 11:20

... blood vessels in various tissues and organs, including the brain, is regulated by the VEGF system in combination with other signaling systems such as the angiopoietin–Tie, ephrin–Eph, Delta–Notch ... family members. By contrast, a pathological increase in the blood supply in the CNS is seen in brain tumors, in particular malignant gliomas. In phase II clinical trials, anti-VEGF...

Ngày tải lên: 18/02/2014, 11:20

... made in dissecting stroke mechanisms involving excitotoxicity and ionic imbalance, oxidative and nitrosative stress, neuroinflammation and apoptotic-like pathways in neurons. However, clinically ... for t-PA-induced intracranial bleeding in mouse models of focal stroke [37]. In this model, co-treatment with the broad-spectrum MMP inhibitor GM6001 effectively reduced intracranial bleedi...

Ngày tải lên: 18/02/2014, 11:20

... B do- mains being part of the phosphorylation chain and the EIIC domain representing the membrane domain. As all components of the PTS, depending on their phos- phorylation status, can interact ... transport protein for glucose uptake); FBA, flux balance analysis (tool to determine the flux distribution in cellular networks, requires steady-state conditions); HPr, histidine-containing protein...

Ngày tải lên: 18/02/2014, 13:20

... code for a single protein. Interestingly, during the initial process of identifying the NR family members in the A. aegypti genome, we predicted two isoforms of AaFTZ-F1, differing only in their ... dis- played in AaHNF-4A in hormone-free media that har- bors a complete balance of amino acids suggests the involvement of amino acids in its regulation. This amino acid induced signal r...

Ngày tải lên: 18/02/2014, 13:20