... NADP(H)
binding domain in pink, and the FAD prosthetic group in yellow. (B) Detailed view of the isoalloxazine ring system in FNR, displaying relevant
interactions with active site amino acid ... The
flavoprotein molecule is made up of two structural domains,
each containing approximately 150 amino acids (Fig. 1A).
The carboxyl terminal region includes most of the residues
involved in...
... may coin-
cide in place, as in the question '~here are we now?".
(b) The conversants ~ay be contained in the target, as
in the question "Where is Israel?" when Posed in Jerus- ... parti-
cipants in the conversation. Several loci in the data
are indicative of this last pattern. First none of the
Americans indicated that the Empire State Building was
&quo...
... protein tyrosine kinases. These kinas-
es result in the increased tyrosine phosphorylation of
multiple macrophage proteins and the activation of
phospholipase D [82]. Activation of protein tyrosine
kinases ... mutation in the GTP-binding domain sup-
presses temperature-sensitive chromosome partitioning
mutations, indicating that Era is a cell-cycle check-
point regulator [89,90].
Interest...
... (2008) Mapping
alpha-helical induced folding within the intrinsically dis-
ordered C-terminal domain of the measles virus nucleo-
protein by site-directed spin-labeling EPR spectroscopy.
Proteins 73, ... B, Finet S &
Longhi S (2005) The intrinsically disordered C-terminal
domain of the measles virus nucleoprotein interacts with
the C-terminal domain of the phosphoprotein via two
distinct...
... are linked to accessory proteins (e.g. zonula
occludens proteins and cingulin), forging a connection
to the actin cytoskeletons of endothelial cells [8]. Occlu-
din is an 65 kDa phosphoprotein ... Claudins are 22 kDa
phosphoproteins that are thought to help maintain
high transendothelial electrical resistance. Three types
of claudins (claudin1 ⁄ 3, claudin5 and claudin12) are
found in ....
... blood vessels in various tissues and organs,
including the brain, is regulated by the VEGF system
in combination with other signaling systems such as
the angiopoietin–Tie, ephrin–Eph, Delta–Notch ... family
members. By contrast, a pathological increase in the blood supply in the
CNS is seen in brain tumors, in particular malignant gliomas. In phase II
clinical trials, anti-VEGF...
... made
in dissecting stroke mechanisms involving excitotoxicity
and ionic imbalance, oxidative and nitrosative stress,
neuroinflammation and apoptotic-like pathways in
neurons. However, clinically ... for t-PA-induced intracranial bleeding in mouse
models of focal stroke [37]. In this model, co-treatment
with the broad-spectrum MMP inhibitor GM6001
effectively reduced intracranial bleedi...
... B do-
mains being part of the phosphorylation chain and the
EIIC domain representing the membrane domain. As
all components of the PTS, depending on their phos-
phorylation status, can interact ... transport protein for glucose uptake); FBA, flux balance analysis (tool to determine the
flux distribution in cellular networks, requires steady-state conditions); HPr, histidine-containing protein...
... code
for a single protein. Interestingly, during the initial
process of identifying the NR family members in the
A. aegypti genome, we predicted two isoforms of
AaFTZ-F1, differing only in their ... dis-
played in AaHNF-4A in hormone-free media that har-
bors a complete balance of amino acids suggests the
involvement of amino acids in its regulation. This
amino acid induced signal r...