Tài liệu Báo cáo khoa học: Improving Classification of Medical Assertions in Clinical Notes" pdf
... Linguistics Improving Classification of Medical Assertions in Clinical Notes Youngjun Kim Ellen Riloff Stéphane M. Meystre School of Computing School of Computing Department of Biomedical Informatics ... recall gains on the minority classes. 1 Introduction Since the beginning of the new millennium, there has been a growing need in the medical community...
Ngày tải lên: 20/02/2014, 05:20
... learning algo- rithms consisted of vectors of web hits obtained using the 14 most frequent joining terms found in the BNC. The next condition used a vector of web hits obtained using the joining ... and again using all of the joining terms produced the best results. The SVM algorithm produced the best accuracy of all, achieving 50.1% accuracy using the com- bined set of j...
Ngày tải lên: 20/02/2014, 12:20
... being involved in electron transfer, there are a few polar side chains (Glu, Gln) in close vicinity to the ThDP cofactor, which are likely to play important roles for catalysis and binding of phosphate. ... additional E3 binding protein and specific kinases and phosphatases, which control the activity of the complex by reversible phos- phorylation ⁄ dephosphorylation of serine side c...
Ngày tải lên: 18/02/2014, 08:20
Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt
... not repress the level of PPARc protein in committed prea- dipocytes under physiologically relevant conditions. Expression of miR-27 is elevated in obese mice In order to gain insights into the potential ... We further investigated the kinetics of miR-27 expression during adipogenesis using quantitative real-time PCR. As shown in Fig. 1C,D, expression of both miR-27a and miR-27...
Ngày tải lên: 18/02/2014, 08:20
Tài liệu Báo cáo khoa học: The effect of small molecules in modulating the chaperone activity of aB-crystallin against ordered and disordered protein aggregation pdf
... interact with a number of functional groups, including the aromatic side chains of some amino acids, through a stacking mechanism [42]. The interaction of arginine with aromatic amino acids of aB-crystallin ... of insulin. A C B Fig. 2. aB-crystallin protects against the DTT-induced aggregation of insulin, and this activity is enhanced by Arg-HCl. Insulin ( , 0.25 mgÆmL )1 ) was i...
Ngày tải lên: 18/02/2014, 16:20
Tài liệu Báo cáo khoa học: The role of electrostatic interactions in the antitumor activity of dimeric RNases docx
... strong, neutralizing action of the cytosolic RNase inhibitor (cRI), a 50-kDa protein containing 16 leu- cine-rich repeat motifs [7,8]. In fact, onconase from Rana pipiens eggs [9], and seminal RNase ... of EIE were recorded at 30° inter- vals of r from 0 to 360°; (d) the inclination of the dimer major axis with respect to the z axis, hence to the membrane plane, was changed (by incl...
Ngày tải lên: 19/02/2014, 06:20
Tài liệu Báo cáo khoa học: Structural characterization of Ca2+/CaM in complex with the phosphorylase kinase PhK5 peptide pdf
... extension to the protein kinase folds back on the kinase domain and interferes with the substrate binding sites. In the case of the titin and twitchin kinases, the autoinhibitory sequence acts ... hexadecameric enzyme consisting of four copies of four subunits: (abcd) 4 . An intrinsic calmodulin (CaM, the d subunit) binds directly to the c protein kinase chain. The interaction site o...
Ngày tải lên: 19/02/2014, 17:20
Tài liệu Báo cáo khoa học: The role of N-glycosylation in the stability, trafficking and GABA-uptake of GABA-transporter 1 Terminal N-glycans facilitate efficient GABA-uptake activity of the GABA transporter pptx
... evidence that N-glycans, in particular their terminal structures, are involved in regulating the GABA translocation of GAT1, but not in binding of GAT1 to GABA. Transport of GABA by GAT1 across ... blotting. Either anti- GFP mAb MAB2510 or anti-GAT1 pAb was used for the immunostaining. The protein bands obtained in western blotting were analyzed by phosphoimager scanning. The to...
Ngày tải lên: 19/02/2014, 17:20
Tài liệu Báo cáo khoa học: "Topological Ordering of Function Words in Hierarchical Phrase-based Translation" pdf
... Proceedings of the 47th Annual Meeting of the ACL and the 4th IJCNLP of the AFNLP, pages 324–332, Suntec, Singapore, 2-7 August 2009. c 2009 ACL and AFNLP 1
Ngày tải lên: 20/02/2014, 07:20
Tài liệu Báo cáo khoa học: "Automatic Evaluation of Sentence-Level Fluency Andrew Mutton∗" pdf
... were interested in the level of agreement of intuitive un- derstanding of fluency. We instructed them also that they should evaluate the sentence without consider- ing its content, using Colourless ... were high, as indicated by the maximum, minimum and mean values in Table 3, indicating that our assumption that humans had an intuitive notion of fluency and needed only minimal instr...
Ngày tải lên: 20/02/2014, 12:20