... therapeutic and diagnostic tumortargetMichela Capello, Sammy Ferri-Borgogno, Paola Cappello and Francesco NovelliDepartment of Medicine and Experimental Oncology, Center for Experimental Research and ... archaebacteria to mam-mals, and its sequence is highly conserved [3]. In mam-mals, three genes, ENO1, ENO2 and ENO3 encode for three isoforms of the enzyme, a-enolase (ENOA),c-enolase and b-enolase, respectively, ... 917–924.133 Fernandez Madrid F (2005) Autoantibodies in breastcancer sera: candidate biomarkers and reporters oftumorigenesis. Cancer Lett 230, 187–198.a-enolase in tumor diagnosis and therapy...